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  1. Although a variety of treatment guidelines for Type 2 diabetes patients are available, a majority of patients does not achieve recommended targets. We aimed to characterise Type 2 diabetes patients from Swiss ...

    Authors: Anja Frei, Stefanie Herzog, Katja Woitzek, Ulrike Held, Oliver Senn, Thomas Rosemann and Corinne Chmiel
    Citation: Cardiovascular Diabetology 2012 11:70
  2. Type 2 diabetes (2DM), obesity, and coronary artery disease (CAD) are frequently coexisted being as key components of metabolic syndrome. Whether there is shared genetic background underlying these diseases re...

    Authors: Chaoneng Wu, Yunguo Gong, Jie Yuan, Hui Gong, Yunzeng Zou and Junbo Ge
    Citation: Cardiovascular Diabetology 2012 11:68
  3. In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size i...

    Authors: Takayuki Miki, Takahito Itoh, Daisuke Sunaga and Tetsuji Miura
    Citation: Cardiovascular Diabetology 2012 11:67
  4. It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT1R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the ...

    Authors: Yao-Chen Chuang, Ming-Shiou Wu, Yi-Kai Su and Kwang-Ming Fang
    Citation: Cardiovascular Diabetology 2012 11:66
  5. Previous studies suggested that the RhoA/ROCK pathway may contribute to vascular complications in diabetes. The present study was designed to investigate whether ROCK inhibitor fasudil could prevent high gluco...

    Authors: Hailing Li, Wenhui Peng, Weixia Jian, Yuanmin Li, Qi Li, Weiming Li and Yawei Xu
    Citation: Cardiovascular Diabetology 2012 11:65
  6. Glucagon like peptide-1 (GLP-1) receptor agonist treatment may improve endothelial function via direct and indirect mechanisms. We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide...

    Authors: Aaron S Kelly, Richard M Bergenstal, J Michael Gonzalez-Campoy, Harold Katz and Alan J Bank
    Citation: Cardiovascular Diabetology 2012 11:64
  7. The heart derives energy from a wide variety of substrates including fatty acids, carbohydrates, ketones, and amino acids. The healthy heart generates up to 30% of its ATP from glucose. Under conditions of car...

    Authors: Lauren Aerni-Flessner, Melissa Abi-Jaoude, Amanda Koenig, Maria Payne and Paul W Hruz
    Citation: Cardiovascular Diabetology 2012 11:63
  8. The relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood. The aim of this study was to investi...

    Authors: Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim and Kap Bum Huh
    Citation: Cardiovascular Diabetology 2012 11:62
  9. Insulin resistance (IR) is the major driving force behind development and progression of atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD). Therefore, correction of IR is a relevant the...

    Authors: Marina Shargorodsky, Elena Omelchenko, Zipora Matas, Mona Boaz and Dov Gavish
    Citation: Cardiovascular Diabetology 2012 11:61
  10. Diabetic patients present with an accelerated atherosclerotic process and an increased risk for future cardiovascular events. In addition to the risk imposed by the disease itself, pharmacological treatment ad...

    Authors: Robert Klempfner, Jonathan Leor, Alexander Tenenbaum, Enrique Z Fisman and Ilan Goldenberg
    Citation: Cardiovascular Diabetology 2012 11:60
  11. Women with previous gestational diabetes mellitus (pGDM) face a higher risk of developing type 2 diabetes and, consequently, a higher cardiovascular risk. This study aimed to compare the carotid intima-media t...

    Authors: Claudia Maria Vilas Freire, Felipe Batista Lima Barbosa, Maria Cristina C de Almeida, Paulo Augusto Carvalho Miranda, Márcia Melo Barbosa, Anelise Impeliziere Nogueira, Milena Moreira Guimarães, Maria do Carmo Pereira Nunes and Antônio Ribeiro-Oliveira Jr
    Citation: Cardiovascular Diabetology 2012 11:59
  12. Diabetes mellitus is associated with micro- and macrovascular complications and increased cardiovascular risk. Elevated levels of serum asymmetric dimethylarginine (ADMA) may be responsible for endothelial dys...

    Authors: Erik Salum, Priit Kampus, Mihkel Zilmer, Jaan Eha, Mark Butlin, Alberto P Avolio, Taavi Põdramägi, Andres Arend, Marina Aunapuu and Jaak Kals
    Citation: Cardiovascular Diabetology 2012 11:58
  13. Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment...

    Authors: Sabine Fredersdorf, Christian Thumann, Wolfram H Zimmermann, Roland Vetter, Tobias Graf, Andreas Luchner, Günter AJ Riegger, Heribert Schunkert, Thomas Eschenhagen and Joachim Weil
    Citation: Cardiovascular Diabetology 2012 11:57
  14. The prevention of type 2 diabetes is a globally recognised health care priority, but there is a lack of rigorous research investigating optimal methods of translating diabetes prevention programmes, based on t...

    Authors: Laura J Gray, Kamlesh Khunti, Sian Williams, Stephanie Goldby, Jacqui Troughton, Thomas Yates, Alastair Gray and Melanie J Davies
    Citation: Cardiovascular Diabetology 2012 11:56
  15. Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL conc...

    Authors: Dong-Sik Cho, Sookyoung Woo, Seonwoo Kim, Christopher D Byrne, Joon-Hyuk Kong and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2012 11:55
  16. Uncontrolled blood pressure (BP) is a significant contributor of morbidity and even mortality in type 2 diabetes (T2D) patients. This study was done to determine the significant determinants of uncontrolled bl...

    Authors: Boon How Chew, Ismail Mastura, Sazlina Shariff-Ghazali, Ping Yein Lee, Ai Theng Cheong, Zaiton Ahmad, Sri Wahyu Taher, Jamaiyah Haniff, Feisul Idzwan Mustapha and Mohd Adam Bujang
    Citation: Cardiovascular Diabetology 2012 11:54
  17. Both angiotensin II type I receptor blockers (ARBs) and calcium channel blockers (CCBs) are widely used antihypertensive drugs. Many clinical studies have demonstrated and compared the organ-protection effects...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2012 11:53
  18. Admission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk fa...

    Authors: Julio Yoshio Takada, Rogério Bicudo Ramos, Larissa Cardoso Roza, Solange Desiree Avakian, José Antonio Franchini Ramires and Antonio de Pádua Mansur
    Citation: Cardiovascular Diabetology 2012 11:47
  19. The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitation...

    Authors: Gary Huang, Dan Wang, Unab I Khan, Irfan Zeb, JoAnn E Manson, Virginia Miller, Howard N Hodis, Matthew J Budoff, George R Merriam, Mitchell S Harman, Eliot A Brinton, Marcelle I Cedars, Yali Su, Rogerio A Lobo, Frederick Naftolin, Nanette Santoro…
    Citation: Cardiovascular Diabetology 2012 11:52
  20. Although most deaths among patients with type 2 diabetes (T2D) are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The aim ...

    Authors: Ina-Maria Rückert, Michaela Schunk, Rolf Holle, Sabine Schipf, Henry Völzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich and Christa Meisinger
    Citation: Cardiovascular Diabetology 2012 11:50
  21. Chronic elevation of glucose level activates vascular inflammation and increases endothelial adhesiveness to monocytes, an early sign of atherogenesis. This study aimed to elucidate the detailed mechanisms of ...

    Authors: Jia-Shiong Chen, Yung-Hsiang Chen, Po-Hsun Huang, Hsiao-Ya Tsai, Yuh-Lien Chen, Shing-Jong Lin and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2012 11:49
  22. Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. A multitude of new loci has recently been reported, but the...

    Authors: Peter M Schmid, Iris Heid, Christa Buechler, Andreas Steege, Markus Resch, Christoph Birner, Dierk H Endemann, Guenter A Riegger and Andreas Luchner
    Citation: Cardiovascular Diabetology 2012 11:48
  23. Endothelial progenitor cells (EPCs), especially late EPCs, play a critical role in endothelial maintenance and repair, and postnatal vasculogenesis. Advanced glycation end products (AGEs) have been shown to im...

    Authors: Hong Li, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Yuliang Wang, Hairong Chu and Min Cheng
    Citation: Cardiovascular Diabetology 2012 11:46
  24. Metabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by the International Diabetes Fede...

    Authors: I-Te Lee, Yen-Feng Chiu, Chii-Min Hwu, Chih-Tsueng He, Fu-Tien Chiang, Yu-Chun Lin, Themistocles Assimes, J David Curb and Wayne H-H Sheu
    Citation: Cardiovascular Diabetology 2012 11:43
  25. Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF − 945 G/C polymorphism is associated with susceptibility to systemic sclerosis, ...

    Authors: Sheila K Patel, Bryan Wai, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Michelle Ord, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava and Louise M Burrell
    Citation: Cardiovascular Diabetology 2012 11:42
  26. Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs6593...

    Authors: Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo and Safarina G Malik
    Citation: Cardiovascular Diabetology 2012 11:41
  27. Serum C-reactive protein (CRP) and leptin levels have been independently associated with the cardiovascular risk factors. The aim of the present study was to determine if their serum levels were associated wit...

    Authors: Feng-Hsiang Chiu, Chung Hsun Chuang, Wen-Cheng Li, Yi-Ming Weng, Wen-Chih Fann, Hsiang-Yun Lo, Cheng Sun and Shih-Hao Wang
    Citation: Cardiovascular Diabetology 2012 11:40
  28. Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.

    Authors: Chang-Hee Kwon, Eun-Jung Rhee, Jae-Uk Song, Jung-Tae Kim, Hyon Joo Kwag and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2012 11:38
  29. The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the ...

    Authors: Rajesh Chaudhary, Atip Likidlilid, Thavatchai Peerapatdit, Damras Tresukosol, Sorachai Srisuma, Suphachai Ratanamaneechat and Charn Sriratanasathavorn
    Citation: Cardiovascular Diabetology 2012 11:36
  30. Health utility (HU) measures are used as overall measures of quality of life and to determine quality adjusted life years (QALYs) in economic analyses. We compared baseline values of three HUs including Short ...

    Authors: Dennis W Raisch, Patricia Feeney, David C Goff Jr, KM Venkat Narayan, Patrick J O’Connor, Ping Zhang, Don G Hire and Mark D Sullivan
    Citation: Cardiovascular Diabetology 2012 11:35
  31. Since betaine is an osmolyte and methyl donor, and abnormal betaine loss is common in diabetes mellitus (>20% patients), we investigated the relationship between betaine and the post-methionine load rise in ho...

    Authors: Michael Lever, Sandy Slow, David O McGregor, Warwick J Dellow, Peter M George and Stephen T Chambers
    Citation: Cardiovascular Diabetology 2012 11:34
  32. A higher increase in intracellular Na+ via Na+/H+ exchanger (NHE) during ischemia has been reported in type 2 diabetic mouse hearts. We investigated the role of NHE in inducing changes in cytoplasmic Ca2+ concent...

    Authors: Ryuko Anzawa, Shingo Seki, Tomohisa Nagoshi, Ikuo Taniguchi, Danielle Feuvray and Michihiro Yoshimura
    Citation: Cardiovascular Diabetology 2012 11:33
  33. Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular (CV) events, comorbid diabetes mellitus, microalbuminuria and renal im...

    Authors: Samir G Mallat
    Citation: Cardiovascular Diabetology 2012 11:32
  34. The metabolic syndrome is associated with increased risk for both diabetes and coronary artery disease, which insulin resistance alone does not satisfactorily explain. We propose an additional and complementar...

    Authors: Surujpal Teelucksingh, Sarada Jaimungal, Lexley Pinto Pereira, Terence Seemungal and Shivananda Nayak
    Citation: Cardiovascular Diabetology 2012 11:31
  35. Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recen...

    Authors: Louise J Maple-Brown, Joan Cunningham, Bernard Zinman, Mary Mamakeesick, Stewart B Harris, Philip W Connelly, Jonathan Shaw, Kerin O'Dea and Anthony J Hanley
    Citation: Cardiovascular Diabetology 2012 11:30
  36. The hypoglycemic effect of bezafibrate is well established, but administration to a large population of patients with diabetes has not been reported. We investigated glycemic control, relationship between lipi...

    Authors: Tamio Teramoto, Kohji Shirai, Hiroyuki Daida and Nobuhiro Yamada
    Citation: Cardiovascular Diabetology 2012 11:29
  37. The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, an...

    Authors: Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa and Koji Sumikawa
    Citation: Cardiovascular Diabetology 2012 11:28
  38. The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early eve...

    Authors: Linnéa Eriksson, Özlem Erdogdu, Thomas Nyström, Qimin Zhang and Åke Sjöholm
    Citation: Cardiovascular Diabetology 2012 11:27
  39. Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involve...

    Authors: Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2012 11:26
  40. People with central obesity have an increased risk for developing the metabolic syndrome, type 2 diabetes and cardiovascular disease. However, a substantial part of obese individuals have no other cardiovascul...

    Authors: Corine den Engelsen, Paula S Koekkoek, Kees J Gorter, Maureen van den Donk, Philippe L Salomé and Guy E Rutten
    Citation: Cardiovascular Diabetology 2012 11:25
  41. Cardiac autonomic neuropathy (CAN) is a common complication of diabetes associated with poor prognosis. In addition, the autonomic imbalance is associated with cardiovascular disease (CVD) in diabetes. It is t...

    Authors: Chan-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Sang-Hee Jung and Ji-Oh Mok
    Citation: Cardiovascular Diabetology 2012 11:24
  42. Premature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in a...

    Authors: Liana C Del Gobbo, Yiqing Song, Paul Poirier, Eric Dewailly, Ronald J Elin and Grace M Egeland
    Citation: Cardiovascular Diabetology 2012 11:23
  43. B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is ...

    Authors: Hideaki Nakatsuji, Ken Kishida, Tohru Funahashi, Tohru Nakagawa and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2012 11:22
  44. Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by ...

    Authors: Chih-Sheng Chu, Kun-Tai Lee, Kai-Hong Cheng, Min-Yi Lee, Hsuan-Fu Kuo, Tsung-Hsien Lin, Ho-Ming Su, Wen-Chol Voon, Sheng-Hsiung Sheu and Wen-Ter Lai
    Citation: Cardiovascular Diabetology 2012 11:21
  45. Visceral adiposity index (VAI) has recently been suggested to be used as a surrogate of visceral adiposity. We examined if VAI could improve predictive performances for CVD of the Framingham's general CVD algo...

    Authors: Bozorgmanesh Mohammadreza, Hadaegh Farzad, Khalili Davoud and Azizi Fereidoun Prof
    Citation: Cardiovascular Diabetology 2012 11:20
  46. Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predic...

    Authors: Henrik Reinhard, Peter R Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen
    Citation: Cardiovascular Diabetology 2012 11:19

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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