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  2. Women with gestational diabetes history are at increased risk for type 2 diabetes. They face specific challenges for behavioural changes, including childcare responsibilities. The aim of this study is to test ...

    Authors: Anne-Sophie Brazeau, Aaron Leong, Sara J Meltzer, Rani Cruz, Deborah DaCosta, Mary Hendrickson-Nelson, Lawrence Joseph and Kaberi Dasgupta
    Citation: Cardiovascular Diabetology 2014 13:104
    Content type: Original investigation Published on:

  4. Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely...

    Authors: Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans-Juergen Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2014 13:102
    Content type: Study protocol Published on:

  5. Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies have shown that the number of circulating endothelial progenitor cell...

    Authors: Natália António, Rosa Fernandes, Ana Soares, Francisco Soares, Ana Lopes, Tiago Carvalheiro, Artur Paiva, Guilherme Mariano Pêgo, Luís A Providência, Lino Gonçalves and Carlos Fontes Ribeiro
    Citation: Cardiovascular Diabetology 2014 13:101
    Content type: Original investigation Published on:

  6. Heart disease is the leading cause of death in diabetic patients, and defective copper metabolism may play important roles in the pathogenesis of diabetic cardiomyopathy (DCM). The present study sought to dete...

    Authors: Shaoping Zhang, Hong Liu, Greeshma V Amarsingh, Carlos C H Cheung, Sebastian Hogl, Umayal Narayanan, Lin Zhang, Selina McHarg, Jingshu Xu, Deming Gong, John Kennedy, Bernard Barry, Yee Soon Choong, Anthony R J Phillips and Garth J S Cooper
    Citation: Cardiovascular Diabetology 2014 13:100
    Content type: Original investigation Published on:

  7. Vascular endothelial dysfunction is involved in macrovascular disease progression in type 2 diabetes mellitus (T2DM). We reported previously that blood glucose fluctuations, as evaluated by continuous glucose ...

    Authors: Keiichi Torimoto, Yosuke Okada, Hiroko Mori and Yoshiya Tanaka
    Citation: Cardiovascular Diabetology 2014 13:99
    Content type: Original investigation Published on:

  8. Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protect...

    Authors: Yi-Jin Ho, An-Sheng Lee, Wen-Pin Chen, Wei-Lung Chang, Ying-Kang Tsai, Hsi-Lin Chiu, Yueh-Hsiung Kuo and Ming-Jai Su
    Citation: Cardiovascular Diabetology 2014 13:98
    Content type: Original investigation Published on:

  9. Vascular smooth muscle cells (VSMCs) proliferation and migration, which are central in the development of vascular diseases, are regulated by numerous hormones and humoral factors. Activation of the insulin re...

    Authors: Changqing Yu, Zhen Wang, Yu Han, Yukai Liu, Wei Eric Wang, Caiyu Chen, Hongyong Wang, Pedro A Jose and Chunyu Zeng
    Citation: Cardiovascular Diabetology 2014 13:97
    Content type: Original investigation Published on:

  10. The dipeptidyl-peptidase-IV (DPP-4) inhibitors, including sitagliptin, are used for the treatment of type 2 diabetes mellitus (T2DM). Adiponectin, an adipocyte-derived circulating protein, has anti-atheroscler...

    Authors: Toshiyuki Hibuse, Norikazu Maeda, Ken Kishida, Takekazu Kimura, Tomoko Minami, Eriko Takeshita, Ayumu Hirata, Yasuhiko Nakagawa, Susumu Kashine, Akemi Oka, Masumi Hayashi, Hitoshi Nishizawa, Tohru Funahashi and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2014 13:96
    Content type: Original investigation Published on:

  12. We aimed to assess the safety and tolerability of different doses of canakinumab versus placebo in patients with type 2 diabetes mellitus (T2DM).

    Authors: Campbell Howard, Adele Noe, Andrej Skerjanec, Björn Holzhauer, Margaret Wernsing, Monica Ligueros-Saylan and Tom Thuren
    Citation: Cardiovascular Diabetology 2014 13:94
    Content type: Original investigation Published on:

  13. Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training do...

    Authors: Christian Cadeddu, Silvio Nocco, Lucia Cugusi, Martino Deidda, Alessandro Bina, Orru Fabio, Stefano Bandinu, Efisio Cossu, Marco Giorgio Baroni and Giuseppe Mercuro
    Citation: Cardiovascular Diabetology 2014 13:93
    Content type: Original investigation Published on:

  14. Type 2 diabetes (T2D) is associated with reduction and dysfunction of circulating pro-angiogenic cells (PACs). DPP-4 inhibitors, a class of oral agents for T2D, might possess pleiotropic vasculoprotective acti...

    Authors: Nicol Poncina, Mattia Albiero, Lisa Menegazzo, Roberta Cappellari, Angelo Avogaro and Gian Paolo Fadini
    Citation: Cardiovascular Diabetology 2014 13:92
    Content type: Original investigation Published on:

  15. Angiotensin receptor blockers (ARBs) have been shown to exert various peroxisome proliferator-activated receptor gamma (PPARγ) binding activities and insulin-sensitizing effects. The objective of this study wa...

    Authors: Chia-Hsuin Chang, Yi-Cheng Chang, Li-Chiu Wu, Jou-Wei Lin, Lee-Ming Chuang and Mei-Shu Lai
    Citation: Cardiovascular Diabetology 2014 13:91
    Content type: Original investigation Published on:

  16. The genetic polymorphism concerning the ß3-subunit of platelet integrin receptor glycoprotein IIIa is held responsible for enhanced binding of adhesive proteins resulting in increased thrombogenic potential. W...

    Authors: Bernd Stratmann, Tao Xu, Christa Meisinger, Barbara Menart, Michael Roden, Christian Herder, Harald Grallert, Annette Peters, Wolfgang Koenig, Thomas Illig, Heinz-Erich Wichmann, Rui Wang-Sattler, Wolfgang Rathmann and Diethelm Tschoepe
    Citation: Cardiovascular Diabetology 2014 13:90
    Content type: Original investigation Published on:

  17. Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) contributes to the pathogenesis of the f...

    Authors: Antoinette Bugyei-Twum, Andrew Advani, Suzanne L Advani, Yuan Zhang, Kerri Thai, Darren J Kelly and Kim A Connelly
    Citation: Cardiovascular Diabetology 2014 13:89
    Content type: Original investigation Published on:

  18. The present study was to investigate the role of calpain in reactive oxygen species (ROS) production in endothelial cells and endothelium-dependent vascular dysfunction under experimental conditions of diabetes.

    Authors: Bainian Chen, Qing Zhao, Rui Ni, Futian Tang, Limei Shan, Inga Cepinskas, Gediminas Cepinskas, Wang Wang, Peter W Schiller and Tianqing Peng
    Citation: Cardiovascular Diabetology 2014 13:88
    Content type: Original investigation Published on:

  19. Intima-media thickness (IMT) of the common carotid artery is a surrogate end point of cardiovascular disease (CVD). Identifying the factors associated with a higher IMT may contribute to the identification of ...

    Authors: Carlos Roberto Moraes de Andrade Junior, Eliete Leão Clemente Silva, Maria de Fátima Bevilaqua da Matta, Marcia Bueno Castier, Maria Luiza Garcia Rosa and Marília de Brito Gomes
    Citation: Cardiovascular Diabetology 2014 13:87
    Content type: Original investigation Published on:

  20. Insulin resistance, as a key mediator of metabolic syndrome, is thought to be associated with pathogenesis of calcific aortic valve disease and altered left ventricular (LV) function and structure. However, in...

    Authors: Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Takayuki Hidaka and Yasuki Kihara
    Citation: Cardiovascular Diabetology 2014 13:86
    Content type: Original investigation Published on:

  21. Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of...

    Authors: Sophie Liabeuf, Bourron Olivier, Cees Vemeer, Elke Theuwissen, Elke Magdeleyns, Carole Elodie Aubert, Michel Brazier, Romuald Mentaverri, Agnes Hartemann and Ziad A Massy
    Citation: Cardiovascular Diabetology 2014 13:85
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:9

  22. Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident c...

    Authors: Taro Narumi, Tetsu Watanabe, Shinpei Kadowaki, Daisuke Kinoshita, Miyuki Yokoyama, Yuki Honda, Yoichiro Otaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto and Isao Kubota
    Citation: Cardiovascular Diabetology 2014 13:84
    Content type: Original investigation Published on:

  23. The presence of impaired glucose tolerance (IGT) and metabolic syndrome (MetS) are two risk factors for Type 2 diabetes. The inter-relatedness of these factors among adolescents is unclear.

    Authors: Mark D DeBoer and Matthew J Gurka
    Citation: Cardiovascular Diabetology 2014 13:83
    Content type: Original investigation Published on:

  24. Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells. Whether lipid content of HDL, especial...

    Authors: Xunliang Tong, Pu Lv, Anna V Mathew, Donghui Liu, Chenguang Niu, Yan Wang, Liang Ji, Jizhao Li, Zhiwei Fu, Bing Pan, Subramaniam Pennathur, Lemin Zheng and Yining Huang
    Citation: Cardiovascular Diabetology 2014 13:82
    Content type: Original investigation Published on:

  25. In the emerging landscape of cardiovascular (CV) outcome trials evaluating the effects of blood glucose lowering drugs in individuals with type 2 diabetes, it is becoming increasingly apparent that since the p...

    Authors: Eberhard Standl, Michael J Theodorakis, Michael Erbach, Oliver Schnell and Jaakko Tuomilehto
    Citation: Cardiovascular Diabetology 2014 13:81
    Content type: Review Published on:

  26. Pharmaceutical interventions for diabetes aim to control glycaemia and to prevent the development of complications, such as cardiovascular diseases. Some anti-hyperglycaemic drugs have been found to have adver...

    Authors: Sefaa Al-aryahi, Danielle Kamato, Robel Getachew, Wenhua Zheng, Simon J Potocnik, Neale Cohen, Daniel Guidone, Narin Osman and Peter J Little
    Citation: Cardiovascular Diabetology 2014 13:80
    Content type: Original investigation Published on:

  27. Diabetes induces numerous electrical, ionic and biochemical defects in the heart. A general feature of diabetic myocardium is its low rate of activity, commonly characterised by prolonged twitch duration. This...

    Authors: June-Chiew Han, Kenneth Tran, Poul MF Nielsen, Andrew J Taberner and Denis S Loiselle
    Citation: Cardiovascular Diabetology 2014 13:79
    Content type: Original investigation Published on:

  28. Rat neonate cardiomyocytes were cultured and treated with AGEs at different concentration. Two classic autophagy markers, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1, were detected by wes...

    Authors: Xuwei Hou, Zhaohui Hu, Hanying Xu, Jian Xu, Shunrong Zhang, Yigang Zhong, Xiuying He and Ningfu Wang
    Citation: Cardiovascular Diabetology 2014 13:78
    Content type: Original investigation Published on:

  29. Type 2 diabetes mellitus (T2DM) is a major cardiovascular disease (CVD) risk factor. Identification of genetic risk factors for CVD is important to understand disease risk. Two recent genome-wide association s...

    Authors: Jeremy N Adams, Laura M Raffield, Barry I Freedman, Carl D Langefeld, Maggie CY Ng, J Jeffrey Carr, Amanda J Cox and Donald W Bowden
    Citation: Cardiovascular Diabetology 2014 13:77
    Content type: Original investigation Published on:

  30. Cardiovascular diseases (CVD) are a leading cause of death worldwide including the Middle East. This is caused in part by the dysregulation of adipose tissue leading to increased production of pro-inflammatory...

    Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum
    Citation: Cardiovascular Diabetology 2014 13:76
    Content type: Original investigation Published on:

  31. Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca2+ homeostasis. This study investigated the effects of alterations in Ca2+ homeostasis and sarcoplasmic reticulum Ca2+-associated p...

    Authors: Shu-Mei Zhao, Yong-Liang Wang, Chun-Yan Guo, Jin-Ling Chen and Yong-Quan Wu
    Citation: Cardiovascular Diabetology 2014 13:75
    Content type: Original investigation Published on:

  32. Recent studies have demonstrated a protective effect of osteocalcin (OCN) on glucose homeostasis and metabolic syndrome. However, its role in vascular function remains unknown. This study investigated the cont...

    Authors: Jianxin Dou, Huating Li, Xiaojing Ma, Mingliang Zhang, Qichen Fang, Meiyun Nie, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2014 13:74
    Content type: Original investigation Published on:

  33. Insulin resistance (IR) assessed by the Homeostatic Model Assessment (HOMA) index in the acute phase of myocardial infarction in non-diabetic patients was recently established as an independent predictor of in...

    Authors: Danijela Trifunovic, Sanja Stankovic, Dragana Sobic-Saranovic, Jelena Marinkovic, Marija Petrovic, Dejan Orlic, Branko Beleslin, Marko Banovic, Bosiljka Vujisic-Tesic, Milan Petrovic, Ivana Nedeljkovic, Jelena Stepanovic, Ana Djordjevic-Dikic, Milorad Tesic, Nina Djukanovic, Olga Petrovic…
    Citation: Cardiovascular Diabetology 2014 13:73
    Content type: Original investigation Published on:

  34. Diastolic dysfunction is a key factor in the development and pathology of cardiac dysfunction in diabetes, however the exact underlying mechanism remains unknown, especially in humans. We aimed to measure cont...

    Authors: Regis R Lamberts, Shivanjali J Lingam, Heng-Yu Wang, Ilse AE Bollen, Gillian Hughes, Ivor F Galvin, Richard W Bunton, Andrew Bahn, Rajesh Katare, J Chris Baldi, Michael JA Williams, Pankaj Saxena, Sean Coffey and Peter P Jones
    Citation: Cardiovascular Diabetology 2014 13:72
    Content type: Original investigation Published on:

  35. Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects of bezafibrate on postprandial endothelial dysfunction and...

    Authors: Yuko Ohno, Toru Miyoshi, Yoko Noda, Hiroki Oe, Norihisa Toh, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2014 13:71
    Content type: Original investigation Published on:

  36. Although body mass index (BMI) is the most widely accepted parameter for defining obesity, recent studies have indicated a unique set of patients who exhibit normal BMI and excess body fat (BF), which is terme...

    Authors: Shinae Kang, Chanhee Kyung, Jong Suk Park, Sohee Kim, Seung-Pyo Lee, Min Kyung Kim, Hye Kyung Kim, Kyung Rae Kim, Tae Joo Jeon and Chul Woo Ahn
    Citation: Cardiovascular Diabetology 2014 13:70
    Content type: Original investigation Published on:

  37. It has been reported that GLP-1 agonist exenatide (exendin-4) decreases blood pressure. The dose-dependent vasodilator effect of exendin-4 has previously been demonstrated, although the precise mechanism is no...

    Authors: Eszter Sélley, Szilárd Kun, István András Szijártó, Boglárka Laczy, Tibor Kovács, Ferenc Fülöp, István Wittmann and Gergő A Molnár
    Citation: Cardiovascular Diabetology 2014 13:69
    Content type: Original investigation Published on:

  38. Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular...

    Authors: Andrew Moore, Amol Shindikar, Ingrid Fomison-Nurse, Federica Riu, Pujika E Munasinghe, Thrishila Parshu Ram, Pankaj Saxena, Sean Coffey, Richard W Bunton, Ivor F Galvin, Michael JA Williams, Costanza Emanueli, Paolo Madeddu and Rajesh Katare
    Citation: Cardiovascular Diabetology 2014 13:68
    Content type: Original investigation Published on:

  39. Whereas visceral abdominal adipose tissue (VAT) is associated with cardiometabolic risk, there is debate regarding the role of subcutaneous abdominal adipose tissue (SAT). The aim of this study was to investig...

    Authors: Chan-Hee Jung, Bo-Yeon Kim, Kyu-Jin Kim, Sang-Hee Jung, Chul-Hee Kim, Sung-Koo Kang and Ji-Oh Mok
    Citation: Cardiovascular Diabetology 2014 13:67
    Content type: Original investigation Published on:

  40. The release of recent guidelines for high cholesterol, hypertension and diabetes in the U.S. has been accompanied by great noise and concerns, both in the academic circuits and the lay press. For persons aged ...

    Authors: Katherine Esposito, Antonio Ceriello, Stefano Genovese and Dario Giugliano
    Citation: Cardiovascular Diabetology 2014 13:66
    Content type: Commentary Published on:

  41. In recent years, several oral antidiabetic drugs with new mechanisms of action have become available, expanding the number of treatment options. Sodium/glucose cotransporter-2 (SGLT2) inhibitors are a new clas...

    Authors: Kohei Kaku, Hirotaka Watada, Yasuhiko Iwamoto, Kazunori Utsunomiya, Yasuo Terauchi, Kazuyuki Tobe, Yukio Tanizawa, Eiichi Araki, Masamichi Ueda, Hideki Suganami and Daisuke Watanabe
    Citation: Cardiovascular Diabetology 2014 13:65
    Content type: Original investigation Published on:

  42. Increased levels of the most electronegative type of LDL, L5, have been observed in the plasma of patients with metabolic syndrome (MetS) and ST-segment elevation myocardial infarction and can induce endotheli...

    Authors: An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Jing-Fang Hsu, Ming-Yi Shen, Chia-Ming Chang, Henry Bair, Ming-Jai Su, Kuan-Cheng Chang and Chu-Huang Chen
    Citation: Cardiovascular Diabetology 2014 13:64
    Content type: Original investigation Published on:

  43. High-sensitivity cardiac troponin I(hs-TnI) and T levels(hs-TnT) are sensitive biomarkers of cardiomyocyte turnover or necrosis. Prior studies of the predictive role of hs-TnT in type 2 diabetes mellitus(T2DM)...

    Authors: Kai-Hang Yiu, Kui-Kai Lau, Chun-Ting Zhao, Yap-Hang Chan, Yan Chen, Zhe Zhen, Arthur Wong, Chu-Pak Lau and Hung-Fat Tse
    Citation: Cardiovascular Diabetology 2014 13:63
    Content type: Original investigation Published on:

  44. In type 2 diabetic patients, cardiac events in the perioperative period may be associated with diminished myocardial vasomotor function and endothelial dysfunction. The influence of sevoflurane anaesthesia on ...

    Authors: Carolien SE Bulte, Charissa E van den Brom, Stephan A Loer, Christa Boer and R Arthur Bouwman
    Citation: Cardiovascular Diabetology 2014 13:62
    Content type: Original investigation Published on:

  45. Excess visceral adipose tissue (VAT) is closely associated with the presence of coronary artery plaques that are vulnerable to rupture. Patients with diabetes mellitus (DM) have more VAT than patients without ...

    Authors: Kazuhiro Osawa, Toru Miyoshi, Yasushi Koyama, Shuhei Sato, Noriaki Akagi, Yusuke Morimitsu, Motoki Kubo, Hiroki Sugiyama, Kazufumi Nakamura, Hiroshi Morita, Susumu Kanazawa and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2014 13:61
    Content type: Original investigation Published on:

  46. Advanced glycation end products (AGEs) and receptor RAGE interaction contribute to endothelial cell damage in diabetes. Several thrombogenic abnormalities are also involved in diabetic vascular complications. ...

    Authors: Yuji Ishibashi, Takanori Matsui, Seiji Ueda, Kei Fukami and Sho-ichi Yamagishi
    Citation: Cardiovascular Diabetology 2014 13:60
    Content type: Original investigation Published on:

  47. The National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (NKF’s KDOQI) staging system for chronic kidney disease (CKD) is based primarily on estimated GFR (eGFR). This study aimed at assessi...

    Authors: Giuseppe Pugliese, Anna Solini, Enzo Bonora, Emanuela Orsi, Gianpaolo Zerbini, Cecilia Fondelli, Gabriella Gruden, Franco Cavalot, Olga Lamacchia, Roberto Trevisan, Monica Vedovato and Giuseppe Penno
    Citation: Cardiovascular Diabetology 2014 13:59
    Content type: Original investigation Published on:

  48. Type 1 diabetes mellitus (T1DM) is associated with cerebral compromise, typically found in patients with microangiopathy. Associations between subclinical macroangiopathy and the brain, whether or not in the p...

    Authors: Eelco van Duinkerken, Richard G IJzerman, Nynke J van der Zijl, Frederik Barkhof, Petra JW Pouwels, Menno M Schoonheim, Annette C Moll, Jeannette Boerop, Alette M Wessels, Martin Klein, Frank J Snoek and Michaela Diamant
    Citation: Cardiovascular Diabetology 2014 13:58
    Content type: Original investigation Published on:

  49. The last decades have provided insights into vitamin D physiology linked to glucose homeostasis. Uncertainties remain in obesity due to its intrinsic effects on vitamin D and glucose tolerance.

    Authors: Mattia Bellan, Gabriele Guzzaloni, Maura Rinaldi, Elena Merlotti, Carlotta Ferrari, Antonella Tagliaferri, Mario Pirisi, Gianluca Aimaretti, Massimo Scacchi and Paolo Marzullo
    Citation: Cardiovascular Diabetology 2014 13:57
    Content type: Original investigation Published on:

  50. Non-fasting triglyceride-rich lipoproteins cholesterol (TRL-C) contributes to cardiovascular risk, in that it includes remnant cholesterol (RC). TRL-C is computed as total C - [LDL-C + HDL-C]. Such calculation...

    Authors: Michel P Hermans, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2014 13:56
    Content type: Original investigation Published on:
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