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  1. Concurrent insulin resistance and elevated blood pressure are commonly observed in cardiovascular disease (CVD) and have long been proposed to contribute to CVD. However, the temporal relationship between them...

    Authors: Kuangyi Wu, Huancong Zheng, Weiqiang Wu, Guanzhi Chen, Zefeng Cai, Zhiwei Cai, Yulong Lan, Dan Wu, Shouling Wu and Youren Chen
    Citation: Cardiovascular Diabetology 2023 22:332
    Content type: Research Published on:

  2. Endothelial–mesenchymal transition (EndMT) plays a crucial role in promoting myocardial fibrosis and exacerbating cardiac dysfunction. Dapagliflozin (DAPA) is a sodium–glucose-linked transporter 2 (SGLT-2) inh...

    Authors: Weijie Wang, Yilan Li, Yanxiu Zhang, Tao Ye, Kui Wang, Shuijie Li and Yao Zhang
    Citation: Cardiovascular Diabetology 2023 22:331
    Content type: Research Published on:

  3. This post-hoc analysis of the DELIGHT trial assessed effects of the SGLT2 inhibitor dapagliflozin on iron metabolism and markers of inflammation.

    Authors: Akihiko Koshino, Brendon L. Neuen, Niels Jongs, Carol Pollock, Peter J. Greasley, Eva-Marie Andersson, Ann Hammarstedt, Cecilia Karlsson, Anna Maria Langkilde, Takashi Wada and Hiddo J.L. Heerspink
    Citation: Cardiovascular Diabetology 2023 22:330
    Content type: Research Published on:

  4. Authors: Kamel Mohammedi, Audrey Cordon, Vincent Rigalleau, Ninon Foussard, Céline Bairras-Martin, Thierry Couffinhal, Julien Bezin and Antoine Benard
    Citation: Cardiovascular Diabetology 2023 22:329
    Content type: Matters Arising Published on:

  5. In the Netherlands, more than one million patients have type 2 diabetes (T2D), and approximately 36% of these patients have chronic kidney disease (CKD). Yearly medical costs related to T2D and CKD account for...

    Authors: Sara W. Quist, Alexander V. van Schoonhoven, Stephan J. L. Bakker, Michał Pochopień, Maarten J. Postma, Jeanni M. T. van Loon and Jeroen H. J. Paulissen
    Citation: Cardiovascular Diabetology 2023 22:328
    Content type: Research Published on:

  6. Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabol...

    Authors: Melina Amor, Valentina Bianco, Martin Buerger, Margarete Lechleitner, Nemanja Vujić, Anja Dobrijević, Alena Akhmetshina, Anita Pirchheim, Birgit Schwarz, Ariane R. Pessentheiner, Franziska Baumgartner, Katharina Rampitsch, Silvia Schauer, Iva Klobučar, Vesna Degoricija, Gudrun Pregartner…
    Citation: Cardiovascular Diabetology 2023 22:327
    Content type: Research Published on:

  7. Advanced glycation end products (AGEs) have been linked to cardiovascular disease (CVD), especially coronary heart disease (CHD), but their role in CVD pathogenesis remains unclear. Therefore, we investigated ...

    Authors: Jinluan Chen, Banafsheh Arshi, Komal Waqas, Tianqi Lu, Daniel Bos, M. Arfan Ikram, André G. Uitterlinden, Maryam Kavousi and M. Carola Zillikens
    Citation: Cardiovascular Diabetology 2023 22:326
    Content type: Research Published on:

  8. The triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG index is associated with cardiovascular diseases through renal function is unclear. This study ai...

    Authors: Cancan Cui, Lin Liu, Te zhang, Ling Fang, Zhanhao Mo, Yitian Qi, Jia Zheng, Zhijia Wang, Haikun Xu, Han Yan, Siqi Yue, Xuekui Wang and Zhiyuan Wu
    Citation: Cardiovascular Diabetology 2023 22:325
    Content type: Research Published on:

  9. Bempedoic Acid (BA) is a novel Lipid-Lowering Therapy (LLT). We performed a systematic review and meta-analysis to assess the efficacy and safety of BA in patients with hypercholesterolemia.

    Authors: Ovidio De Filippo, Fabrizio D’Ascenzo, Mario Iannaccone, Maurizio Bertaina, Attilio Leone, Irene Borzillo, Emanuele Ravetti, Andrea Solano, Ilaria Pagliassotto, Marco Nebiolo, Francesco Bruno, Federico Giacobbe, Saverio Muscoli, Silvia Monticone, Maria Felice Brizzi, Giuseppe Biondi Zoccai…
    Citation: Cardiovascular Diabetology 2023 22:324
    Content type: Research Published on:

  10. An obesity paradox has been described in relation to adverse clinical outcomes (e.g., mortality) with lower body mass index (BMI).

    Authors: Tadeusz Osadnik, Dariusz Nowak, Kamila Osadnik, Marek Gierlotka, Adam Windak, Tomasz Tomasik, Mirosław Mastej, Beata Łabuz-Roszak, Kacper Jóźwiak, Gregory Y. H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Naveed Sattar, Marcin Goławski, Jacek Jóźwiak and Maciej Banach
    Citation: Cardiovascular Diabetology 2023 22:323
    Content type: Research Published on:

  11. The triglyceride-glucose (TyG) index has been proposed as a reliable surrogate marker of insulin resistance and an independent predictor of major adverse cardiovascular events (MACEs). Several recent studies h...

    Authors: Shiyi Tao, Lintong Yu, Jun Li, Zicong Xie, Li Huang, Deshuang Yang, Yuqing Tan, Wenjie Zhang, Xuanchun Huang and Tiantian Xue
    Citation: Cardiovascular Diabetology 2023 22:322
    Content type: Research Published on:

  12. This study aimed to investigate the association between the triglyceride–glucose (TyG) index and left ventricular global longitudinal strain (GLS) in patients with coronary heart disease and to examine the rol...

    Authors: Lin Na, Wenjing Cui, Xinqi Li, Jing Chang and Xin Xue
    Citation: Cardiovascular Diabetology 2023 22:321
    Content type: Research Published on:

  13. The Triglyceride-glucose (TyG) index, a novel indicator of insulin resistance, has been associated with mortality from coronary artery diseases, ischemic stroke, and heart failure. In recent years, much emphas...

    Authors: Jiaqi Chen, Kangxiang Wu, Yiying Lin, Mingyuan Huang and Shanghe Xie
    Citation: Cardiovascular Diabetology 2023 22:320
    Content type: Research Published on:

  14. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which have proven cardiovascular benefits, are recommended in people with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD). Howeve...

    Authors: Xi Tan, Yuanjie Liang, Jigar R. Rajpura, Larisa Yedigarova, Josh Noone, Lin Xie, Silvio Inzucchi and Adam de Havenon
    Citation: Cardiovascular Diabetology 2023 22:319
    Content type: Research Published on:

  15. Diabetes mellitus (DM), heart failure (HF) and metabolic dysfunction associated steatotic liver disease (MASLD) are overlapping diseases of increasing prevalence. Because there are still high numbers of patien...

    Authors: Katarzyna Nabrdalik, Hanna Kwiendacz, Krzysztof Irlik, Mirela Hendel, Karolina Drożdż, Agata M. Wijata, Jakub Nalepa, Oliwia Janota, Wiktoria Wójcik, Janusz Gumprecht and Gregory Y. H. Lip
    Citation: Cardiovascular Diabetology 2023 22:318
    Content type: Research Published on:

  16. Diabetes mellitus (DM) is the most common metabolic disease worldwide and a major risk factor for adverse cardiovascular events, while the additive effects of DM on left ventricular (LV) deformation in the res...

    Authors: Yue Gao, Yi-Ning Jiang, Rui Shi, Ying-Kun Guo, Hua-Yan Xu, Chen-Yan Min, Zhi-Gang Yang and Yuan Li
    Citation: Cardiovascular Diabetology 2023 22:317
    Content type: Research Published on:

  17. Heart failure (HF), chronic kidney disease (CKD), and type 2 diabetes mellitus (T2DM) are common and interrelated conditions, each with a significant burden of disease. HF and kidney disease progress through p...

    Authors: Robert J. Mentz, Stephen A. Brunton and Janani Rangaswami
    Citation: Cardiovascular Diabetology 2023 22:316
    Content type: Research Published on:

  18. The association of glycemic variability with severe consciousness disturbance and in-hospital all-cause mortality in critically ill patients with cerebrovascular disease (CVD) remains unclear, This study aimed...

    Authors: Weimin Cai, Yaling Li, Kun Guo, Xiao Wu, Chao Chen and Xinran Lin
    Citation: Cardiovascular Diabetology 2023 22:315
    Content type: Research Published on:

  19. Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network of microvessels beyond well-known and documented target o...

    Authors: Dídac Mauricio, Mònica Gratacòs and Josep Franch-Nadal
    Citation: Cardiovascular Diabetology 2023 22:314
    Content type: Review Published on:

  20. Atherogenic index of plasma (AIP) has been demonstrated as a surrogate marker for ischemic stroke, but there is limited evidence for the effect of long-term elevation of AIP on ischemic stroke. Therefore, we a...

    Authors: Huancong Zheng, Kuangyi Wu, Weiqiang Wu, Guanzhi Chen, Zekai Chen, Zefeng Cai, Zhiwei Cai, Yulong Lan, Shouling Wu and Youren Chen
    Citation: Cardiovascular Diabetology 2023 22:313
    Content type: Research Published on:

  21. Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammal...

    Authors: Sarah Costantino, Alessandro Mengozzi, Srividya Velagapudi, Shafeeq Ahmed Mohammed, Era Gorica, Alexander Akhmedov, Alessia Mongelli, Nicola Riccardo Pugliese, Stefano Masi, Agostino Virdis, Andreas Hülsmeier, Christian Matthias Matter, Thorsten Hornemann, Giovanni Melina, Frank Ruschitzka, Thomas Felix Luscher…
    Citation: Cardiovascular Diabetology 2023 22:312
    Content type: Research Published on:

  22. Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrol...

    Authors: Liao Tan, Yubo Liu, Jie Liu, Guogang Zhang, Zhaoya Liu and Ruizheng Shi
    Citation: Cardiovascular Diabetology 2023 22:311
    Content type: Research Published on:

  23. There is growing evidence that ceramides play a significant role in the onset and progression of non-alcoholic fatty liver disease (NAFLD), a highly prevalent condition in patients with type 2 diabetes associa...

    Authors: Damien Denimal, Sarah Béland-Bonenfant, Jean-Paul Pais-de-Barros, Alexia Rouland, Benjamin Bouillet, Laurence Duvillard, Bruno Vergès and Jean-Michel Petit
    Citation: Cardiovascular Diabetology 2023 22:310
    Content type: Research Published on:

  24. The triglyceride glucose-body mass (TyG-BMI) index is acknowledged as both a reliable indicator of the risk of cardiovascular disease and an accurate surrogate biomarker for evaluating insulin resistance (IR)....

    Authors: Jiahao Dou, Chen Guo, Yawen Wang, Zihe Peng, Ruiyun Wu, Qiangqiang Li, Hong Zhao, Shoufang Song, Xuelu Sun and Jin Wei
    Citation: Cardiovascular Diabetology 2023 22:309
    Content type: Research Published on:

  25. Previous studies have investigated the association between the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) and the incidence of diabetes in adults and discovered that a high TG/...

    Authors: Hiroki Yuge, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito and Michiaki Fukui
    Citation: Cardiovascular Diabetology 2023 22:308
    Content type: Research Published on:

  26. This study aimed to explore the association between the triglyceride-glucose (TyG) index and the risk of in-hospital mortality in critically ill patients with sepsis.

    Authors: Rui Zheng, Songzan Qian, Yiyi Shi, Chen Lou, Honglei Xu and Jingye Pan
    Citation: Cardiovascular Diabetology 2023 22:307
    Content type: Research Published on:

  27. Gut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood.

    Authors: Huajie Dai, Tianzhichao Hou, Qi Wang, Yanan Hou, Zheng Zhu, Yijie Zhu, Zhiyun Zhao, Mian Li, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Yu Xu, Jieli Lu, Tiange Wang, Guang Ning, Weiqing Wang…
    Citation: Cardiovascular Diabetology 2023 22:306
    Content type: Research Published on:

  28. The triglyceride-glucose (TyG) index has been proposed as a potential predictor of adverse prognosis of coronary heart disease (CHD). However, its prognostic value in patients with CHD and hypertension remains...

    Authors: Shiyi Tao, Lintong Yu, Jun Li, Li Huang, Xuanchun Huang, Wenjie Zhang, Zicong Xie, Yuqing Tan and Deshuang Yang
    Citation: Cardiovascular Diabetology 2023 22:305
    Content type: Research Published on:

  29. Triglyceride-glucose index (TyG) has been widely used to predict cardiovascular outcomes. However, it remains unclear whether TyG holds prognostic significance for patients with coronary chronic total occlusio...

    Authors: Yu Yang, Mengqing Ma, Jian Zhang, Shiyu Jin, Dingxin Zhang and Xianhe Lin
    Citation: Cardiovascular Diabetology 2023 22:304
    Content type: Research Published on:

  30. Diabetic cardiomyopathy (DCM) is a major complication of diabetes and a risk factor for cardiovascular disease. Endothelial dysfunction is central to DCM, and endothelial-to-mesenchymal transition (EndMT) is a...

    Authors: Eric Wang, Shali Chen, Honglin Wang, Tori Chen and Subrata Chakrabarti
    Citation: Cardiovascular Diabetology 2023 22:303
    Content type: Research Published on:

  31. Recent type 2 diabetes guidance from the UK’s National Institute for Health and Care Excellence (NICE) proposes offering SGLT2-inhibitor therapy to people with established atherosclerotic cardiovascular diseas...

    Authors: Katherine G. Young, Rhian Hopkins, Beverley M. Shields, Nicholas J. Thomas, Andrew P. McGovern and John M. Dennis
    Citation: Cardiovascular Diabetology 2023 22:302
    Content type: Comment Published on:

  32. Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs). Type 2 diabetes (T2D) is associated with an increased risk...

    Authors: Sheila González-Salvatierra, Cristina García-Fontana, Jesus Lacal, Francisco Andújar-Vera, Luis Martínez-Heredia, Raquel Sanabria-de la Torre, María Ferrer-Millán, Enrique Moratalla-Aranda, Manuel Muñoz-Torres and Beatriz García-Fontana
    Citation: Cardiovascular Diabetology 2023 22:301
    Content type: Research Published on:

  33. There is uncertainty regarding the role of obesity in type 1 diabetes development. The aim of this systematic review and meta-analysis was to collect and synthesize evidence regarding BMI and the risk of devel...

    Authors: Maya Nitecki, Hertzel C. Gerstein, Yulia Balmakov, Eyal Tsur, Vladislav Babushkin, Tomer Michaeli, Arnon Afek, Orit Pinhas-Hamiel, Tali Cukierman-Yaffe and Gilad Twig
    Citation: Cardiovascular Diabetology 2023 22:300
    Content type: Research Published on:

  34. Circulating N-terminal pro B-type natriuretic peptide (NT-proBNP) is a marker for heart failure in patients with coronary heart disease (CHD) and associated with glycemic abnormalities. Studies on the associat...

    Authors: Tong Yang, Hongmei Zheng, Guangwei Pan, Ruiying Guo, Fengmin Liu, Shengyuan Liu, Shuang Tao, Lin Li, Rongrong Yang and Chunquan Yu
    Citation: Cardiovascular Diabetology 2023 22:299
    Content type: Research Published on:

  35. Uric acid (UA) is an independent prognostic factor for cardiovascular events, but there are no data demonstrating a different risk profile between women and men. Thus, we tested whether UA is associated with a...

    Authors: Maria Perticone, Raffaele Maio, Ermal Shehaj, Simona Gigliotti, Benedetto Caroleo, Edoardo Suraci, Angela Sciacqua, Francesco Andreozzi and Francesco Perticone
    Citation: Cardiovascular Diabetology 2023 22:298
    Content type: Research Published on:

  36. The study aimed to investigate an association of increased liver fibrosis with acute myocardial infarction (AMI), and to investigate the mediating effect of serum follistatin-like protein 3 (FSTL3) on the asso...

    Authors: Wenfei Duan, Ruixiao Shi, Fang Yang, Zhoujunhao Zhou, Lihong Wang, Zhe Huang and Shufei Zang
    Citation: Cardiovascular Diabetology 2023 22:297
    Content type: Research Published on:

  37. We investigated the association of high-sensitivity cardiac troponin (Hs-cTn) with all-cause and cardiovascular mortality in non-diabetic individuals.

    Authors: Lin Liu, Yuen Ting Cheng, Aimin Xu and Bernard M. Y. Cheung
    Citation: Cardiovascular Diabetology 2023 22:296
    Content type: Research Published on:

  38. The study was designed to assess the effect of co-occurrence of diabetes mellitus (DM) and hypertension on the deterioration of left atrioventricular coupling index (LACI) and left atrial (LA) function in comp...

    Authors: Rui Shi, Yi-Ning Jiang, Wen-Lei Qian, Ying-Kun Guo, Yue Gao, Li-Ting Shen, Li Jiang, Xue-Ming Li, Zhi-Gang Yang and Yuan Li
    Citation: Cardiovascular Diabetology 2023 22:295
    Content type: Research Published on:

  39. The PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated phospho-AKT also translocates to mitochondria in the myocardium. Mouse mod...

    Authors: Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li and Ping H. Wang
    Citation: Cardiovascular Diabetology 2023 22:294
    Content type: Research Published on:

  40. Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical r...

    Authors: Wei Jiang, Chun Gan, Xindi Zhou, Qing Yang, Dan Chen, Han Xiao, Lujun Dai, Yaxi Chen, Mo Wang, Haiping Yang and Qiu Li
    Citation: Cardiovascular Diabetology 2023 22:293
    Content type: Research Published on:

  41. The triglyceride-glucose (TyG) index has been suggested as a dependable indicator for predicting major adverse cardiovascular events (MACE) in individuals with cardiovascular conditions. Nevertheless, there is...

    Authors: Enmin Xie, Zixiang Ye, Yaxin Wu, Xuecheng Zhao, Yike Li, Nan Shen, Yanxiang Gao and Jingang Zheng
    Citation: Cardiovascular Diabetology 2023 22:292
    Content type: Research Published on:

  42. Women with gestational diabetes mellitus (GDM) have higher insulin resistance and/or reduced secretion, an increased risk of future diabetes and cardiovascular disease, which may be due to a pathological activ...

    Authors: Dan Yedu Quansah, Antje Horsch, Leah Gilbert, Marc Y. Donath and Jardena J. Puder
    Citation: Cardiovascular Diabetology 2023 22:291
    Content type: Research Published on:

  43. A comprehensive network meta-analysis comparing the effects of individual sodium-glucose cotransporter 2 (SGLT2) inhibitors on patients with and without comorbidities including diabetes mellitus (DM), heart fa...

    Authors: Jui-Yi Chen, Heng-Chih Pan, Chih-Chung Shiao, Min-Hsiang Chuang, Chun Yin See, Tzu-Hsuan Yeh, Yafei Yang, Wen-Kai Chu and Vin-Cent Wu
    Citation: Cardiovascular Diabetology 2023 22:290
    Content type: Research Published on:

  44. Coronary bifurcation lesion, as a complex coronary lesion, is associated with higher risk of long-term poor prognosis than non-bifurcation lesions. The triglyceride-glucose (TyG) index has been shown to predic...

    Authors: Jining He, Sheng Yuan, Chenxi Song, Yanjun Song, Xiaohui Bian, Guofeng Gao and Kefei Dou
    Citation: Cardiovascular Diabetology 2023 22:289
    Content type: Research Published on:

  45. Various studies have indicated that stress hyperglycemia ratio (SHR) can reflect true acute hyperglycemic status and is associated with poor outcomes in patients with acute coronary syndrome (ACS). However, da...

    Authors: Enmin Xie, Zixiang Ye, Yaxin Wu, Xuecheng Zhao, Yike Li, Nan Shen, Yanxiang Gao and Jingang Zheng
    Citation: Cardiovascular Diabetology 2023 22:288
    Content type: Research Published on:

  46. Although recent guidelines advocate for HbA1c target individualization, a comprehensive criterion for patient categorization remains absent. This study aimed to categorize HbA1c variability levels and explore ...

    Authors: Junyu Pei, Xiaopu Wang, Zeyu Pei and Xinqun Hu
    Citation: Cardiovascular Diabetology 2023 22:287
    Content type: Research Published on:

  47. The triglyceride-glucose (TyG) index, which is a reliable substitute indicator for insulin resistance, has been considered an independent risk factor for long-term outcomes in patients with cardiovascular dise...

    Authors: Shutong Dong, Zehao Zhao, Xin Huang, Meishi Ma, Zhiqiang Yang, Chu Fan, Hongya Han, Zhijian Wang, Dongmei Shi and Yujie Zhou
    Citation: Cardiovascular Diabetology 2023 22:286
    Content type: Research Published on:

  48. The Triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, is independently associated with the severity of coronary artery lesions and the prognosis of coronary heart disease. The inve...

    Authors: Qiang Chen, Shiqiang Xiong, Zhen Zhang, Xiuqiong Yu, Yingzhong Chen, Tao Ye, Siqi Yang, Lingyao Qi, Xu Chen, Hanxiong Liu, Jingang Zheng and Lin Cai
    Citation: Cardiovascular Diabetology 2023 22:284
    Content type: Research Published on:

  49. Early diagnosis and treatment effectiveness of early-onset coronary artery disease (EOCAD) are crucial, and non-invasive predictive biomarkers are needed for young adults. We aimed to evaluate the usefulness o...

    Authors: Shalaimaiti Shali, Lingfeng Luo, Kang Yao, Xiangdong Sun, Hongyi Wu, Shuning Zhang, Lili Xu, Wei Gao, Jianxuan Li, Juying Qian, Yan Zheng, Yuxiang Dai and Junbo Ge
    Citation: Cardiovascular Diabetology 2023 22:283
    Content type: Research Published on:

  50. Among patients with acute coronary syndrome and percutaneous coronary intervention, stress hyperglycemia ratio (SHR) is primarily associated with short-term unfavorable outcomes. However, the relationship betw...

    Authors: Jin Liu, Yang Zhou, Haozhang Huang, Rui Liu, Yu Kang, Tingting Zhu, Jielan Wu, Yuwei Gao, Yuqi Li, Chenyang Wang, Shiqun Chen, Nianjin Xie, Xueyan Zheng, Ruilin Meng, Yong Liu, Ning Tan…
    Citation: Cardiovascular Diabetology 2023 22:281
    Content type: Research Published on:
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Cardiovascular Diabetology

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