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  1. Left ventricular (LV) diastolic dysfunction (LVDD) is a well-established and early echocardiographic characteristic of diabetic cardiomyopathy. However, there are limited data on the association between impair...

    Authors: Assi Milwidsky, Elad Maor, Shaye Kivity, Anat Berkovitch, Sagit Ben Zekry, Alexander Tenenbaum, Enrique Z. Fisman, Aharon Erez, Shlomo Segev, Yechezkel Sidi, Ilan Goldenberg and Rafael Kuperstein
    Citation: Cardiovascular Diabetology 2015 14:119
  2. We recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in...

    Authors: Vincent M Monnier, Wanjie Sun, Xiaoyu Gao, David R Sell, Patricia A Cleary, John M Lachin and Saul Genuth
    Citation: Cardiovascular Diabetology 2015 14:118

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:138

  3. It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic f...

    Authors: Masafumi Kurajoh, Hidenori Koyama, Manabu Kadoya, Mariko Naka, Akio Miyoshi, Akinori Kanzaki, Miki Kakutani-Hatayama, Hirokazu Okazaki, Takuhito Shoji, Yuji Moriwaki, Tetsuya Yamamoto, Masanori Emoto, Masaaki Inaba and Mitsuyoshi Namba
    Citation: Cardiovascular Diabetology 2015 14:117
  4. The risk of cardiovascular morbidity and mortality is significantly increased in patients with diabetes; thus, it is important to determine whether glucose-lowering therapy affects this risk over time. Changes...

    Authors: Rafael Simó, Bruno Guerci, Guntram Schernthaner, Baptist Gallwitz, Juan Rosas-Guzmàn, Francesco Dotta, Andreas Festa, Ming Zhou and Jacek Kiljański
    Citation: Cardiovascular Diabetology 2015 14:116
  5. Hyperglycemia is the hallmark of diabetes and its cardiovascular complications. Insulin plays an important role in the regulation of vascular homeostasis and maintenance of endothelial function. Insulin signal...

    Authors: Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Roberto Testa, Stefano Genovese and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2015 14:114
  6. The hyperinsulinemia of obesity is a function of both increased pancreatic insulin secretion and decreased insulin clearance, and contributes to cardiovascular risk. Whilst weight loss is known to enhance insu...

    Authors: Nora E. Straznicky, Mariee T. Grima, Carolina I. Sari, Elisabeth A. Lambert, Sarah E. Phillips, Nina Eikelis, Daisuke Kobayashi, Dagmara Hering, Justin A. Mariani, John B. Dixon, Paul J. Nestel, Sofie Karapanagiotidis, Markus P. Schlaich and Gavin W. Lambert
    Citation: Cardiovascular Diabetology 2015 14:113
  7. Betatrophin has been suggested as an inducer of β-cell proliferation in mice in addition to its function in regulating triglyceride. Recent data showed that betatrophin was increased in Type 2 Diabetes (T2D), ...

    Authors: Mohamed Abu-Farha, Jehad Abubaker, Fiona Noronha, Irina Al-Khairi, Preethi Cherian, Monira Alarouj, Abdullah Bennakhi and Naser Elkum
    Citation: Cardiovascular Diabetology 2015 14:112
  8. Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood glucose variability and coronary pl...

    Authors: Kozo Okada, Kiyoshi Hibi, Masaomi Gohbara, Shunsuke Kataoka, Keiko Takano, Eiichi Akiyama, Yasushi Matsuzawa, Kenichiro Saka, Nobuhiko Maejima, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J. Fitzgerald, Yasuhiro Honda…
    Citation: Cardiovascular Diabetology 2015 14:111
  9. The Global Registry of Acute Coronary Events (GRACE) risk score is widely recommended for risk assessment in patients with acute coronary syndrome (ACS). Chronic hyperglycemia [hemoglobinA1c (HbA1c)] can indep...

    Authors: Xiao-Jun Liu, Zhao-Fei Wan, Na Zhao, Ya-Ping Zhang, Lan Mi, Xin-Hong Wang, Dong Zhou, Yan Wu and Zu-Yi Yuan
    Citation: Cardiovascular Diabetology 2015 14:110
  10. With the increasing trend of metabolic syndrome (MetS) and atherothrombotic stroke (which can manifest as stroke lesion multiplicity), studies on the association between MetS and the clinical aspects of athero...

    Authors: Kazuhiko Kotani, Noriko Satoh-Asahara, Takuya Nakakuki, Hajime Yamakage, Akira Shimatsu and Tetsuya Tsukahara
    Citation: Cardiovascular Diabetology 2015 14:108
  11. We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diab...

    Authors: Marilia C O Sprandel, Whady A Hueb, Alexandre Segre, José A F Ramires, Roberto Kalil-Filho and Raul C Maranhão
    Citation: Cardiovascular Diabetology 2015 14:107
  12. Coronary microvascular dysfunction (CMD) is associated with cardiovascular events in type 2 diabetes mellitus (T2DM). Optimal glycaemic control does not always preclude future events. We sought to assess the e...

    Authors: Luis Felipe Valenzuela-Garcia, Yasushi Matsuzawa, Jaskanwal D S Sara, Taek-Geun Kwon, Ryan J Lennon, Lilach O Lerman, Rafael J Ruiz-Salmeron and Amir Lerman
    Citation: Cardiovascular Diabetology 2015 14:106
  13. Studies on the long-term effectiveness of multidisciplinary risk-stratification based management in Chinese population were rare. This study aimed to evaluate the effectiveness of a multidisciplinary risk ass...

    Authors: Fangfang Jiao, Colman Siu Cheung Fung, Yuk Fai Wan, Sarah Morag McGhee, Carlos King Ho Wong, Daisy Dai, Ruby Kwok and Cindy Lo Kuen Lam
    Citation: Cardiovascular Diabetology 2015 14:105
  14. Vascular calcification is an independent risk factor for cardiovascular disease. Diabetes mellitus increases the incidence of vascular calcification; however, detailed molecular mechanisms of vascular calcific...

    Authors: Yuya Terao, Seimi Satomi-Kobayashi, Ken-ichi Hirata and Yoshiyuki Rikitake
    Citation: Cardiovascular Diabetology 2015 14:104
  15. Type 2 diabetes mellitus (T2DM) worsens the outcome after myocardial infarction (MI). Here, we hypothesized that inhibition of dipeptidyl peptidase-4 (DPP-4) improves survival after MI in T2DM by modifying aut...

    Authors: Hiromichi Murase, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Satoko Ishikawa, Toshiyuki Tobisawa, Makoto Ogasawara, Keitaro Nishizawa and Tetsuji Miura
    Citation: Cardiovascular Diabetology 2015 14:103
  16. Enhancement of myocardial glucose uptake may reduce fatty acid oxidation and improve tolerance to ischemia. Hyperglycemia, in association with hyperinsulinemia, stimulates this metabolic change but may have d...

    Authors: Liam M McCormick, Patrick M Heck, Liam S Ring, Anna C Kydd, Sophie J Clarke, Stephen P Hoole and David P Dutka
    Citation: Cardiovascular Diabetology 2015 14:102
  17. Obesity is a recognized risk factor for various cardiometabolic diseases and several indices are used clinically to assess overall cardiometabolic risk. This study aims to determine the sensitivity of six anth...

    Authors: Nasser M Al-Daghri, Omar S Al-Attas, Kaiser Wani, Abdullah M Alnaami, Shaun Sabico, Abdulrahman Al-Ajlan, George P Chrousos and Majed S Alokail
    Citation: Cardiovascular Diabetology 2015 14:101
  18. The aim of the study was to evaluate the effect of delay in treatment intensification (IT; clinical inertia) in conjunction with glycaemic burden on the risk of macrovascular events (CVE) in type 2 diabetes (T...

    Authors: Sanjoy K Paul, Kerenaftali Klein, Brian L Thorsted, Michael L Wolden and Kamlesh Khunti
    Citation: Cardiovascular Diabetology 2015 14:100
  19. Recent evidence indicates that inhibition of histone deacetylase (HDAC) protects the heart against myocardial injury and stimulates endogenous angiomyogenesis. However, it remains unknown whether HDAC inhibiti...

    Authors: Youfang Chen, Jianfeng Du, Yu Tina Zhao, Ling Zhang, Guorong Lv, Shougang Zhuang, Gangjian Qin and Ting C Zhao
    Citation: Cardiovascular Diabetology 2015 14:99
  20. Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failu...

    Authors: Takayuki Kawata, Masao Daimon, Sakiko Miyazaki, Ryoko Ichikawa, Masaki Maruyama, Shuo-Ju Chiang, Chiharu Ito, Fumihiko Sato, Hirotaka Watada and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2015 14:98
  21. In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased and represents an important independent mechanism by which heart disease is exacerbated. The pathogenesis of diabetic car...

    Authors: Jun He, Megan T Quintana, Jenyth Sullivan, Traci L Parry, Trisha J Grevengoed, Jonathan C Schisler, Joseph A Hill, Cecelia C Yates, Rudo F Mapanga, M Faadiel Essop, William E Stansfield, James R Bain, Christopher B Newgard, Michael J Muehlbauer, Yipin Han, Brian A Clarke…
    Citation: Cardiovascular Diabetology 2015 14:97
  22. To evaluate the relevance of adding acetylsalicylic acid (ASA) in primary prevention in subjects with type 2 diabetes mellitus.

    Authors: Giuseppe Derosa, Amedeo Mugellini, Rosa M Pesce, Angela D’Angelo and Pamela Maffioli
    Citation: Cardiovascular Diabetology 2015 14:95
  23. Acute hyperglycemia co-presenting with myocardial infarction (in diabetic and non-diabetic individuals) is often associated with a poor prognosis. Although acute hyperglycemia induces oxidative stress that can...

    Authors: Buin Adams, Rudo F Mapanga and M Faadiel Essop
    Citation: Cardiovascular Diabetology 2015 14:94
  24. Patients with type 2 diabetes have a high risk for early and extensive development of peripheral arterial disease (PAD) and this excess risk is not explained by increased burden of traditional atherosclerotic ...

    Authors: Jonas Malmstedt, Lars Kärvestedt, Jesper Swedenborg and Kerstin Brismar
    Citation: Cardiovascular Diabetology 2015 14:93
  25. Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes...

    Authors: Mark T Waddingham, Amanda J Edgley, Alberto Astolfo, Tadakatsu Inagaki, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Hirotsugu Tsuchimochi, Naoto Yagi, Darren J Kelly, Mikiyasu Shirai and James T Pearson
    Citation: Cardiovascular Diabetology 2015 14:92
  26. Insulin-induced microvascular recruitment is important for optimal muscle glucose uptake. 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR, an activator of AMP-activated protein kinase), can also induce...

    Authors: Eloise A Bradley, Lei Zhang, Amanda J Genders, Stephen M Richards, Stephen Rattigan and Michelle A Keske
    Citation: Cardiovascular Diabetology 2015 14:91
  27. Oxidative stress plays a major role in diabetic cardiomyopathy pathogenesis. Anti-oxidant therapy has been investigated in preventing or treating several diabetic complications. However, anti-oxidant action on...

    Authors: Julliano F C Guimaraes, Bruno P Muzio, Camila M Rosa, Andre F Nascimento, Mario M Sugizaki, Ana A H Fernandes, Antonio C Cicogna, Carlos R Padovani, Marina P Okoshi and Katashi Okoshi
    Citation: Cardiovascular Diabetology 2015 14:90
  28. Skin autofluorescence is a non-invasive measurement of advanced glycation end products (AGE), which are suggested to be one of the major agents in the pathogenesis and progression of diabetes related cardiovas...

    Authors: Y H M Krul-Poel, R Agca, P Lips, H van Wijland, F Stam and S Simsek
    Citation: Cardiovascular Diabetology 2015 14:89
  29. It is uncertain whether non-alcoholic fatty liver disease (NAFLD) or abdominal obesity is more associated with atherosclerosis. The aim of this study was to determine whether NAFLD or abdominal obesity is more...

    Authors: Min-Kyung Lee, Hye-Jeong Park, Won Seon Jeon, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park and Eun-Jung Rhee
    Citation: Cardiovascular Diabetology 2015 14:88
  30. Type 2 diabetes is associated with abnormal electrical conduction and sudden cardiac death, but the pathogenic mechanism remains unknown. This study describes electrophysiological alterations in a diet-induced...

    Authors: Lene Nygaard Axelsen, Kirstine Calloe, Thomas Hartig Braunstein, Mads Riemann, Johannes Pauli Hofgaard, Bo Liang, Christa Funch Jensen, Kristine Boisen Olsen, Emil D. Bartels, Ulrik Baandrup, Thomas Jespersen, Lars Bo Nielsen, Niels-Henrik Holstein-Rathlou and Morten Schak Nielsen
    Citation: Cardiovascular Diabetology 2015 14:87
  31. Strokes are commonly preceded by transient ischemic attacks (TIAs). TIA is often associated with metabolic syndrome (causing chronic inflammation), resulting in a proinflammatory- and procoagulant-environment....

    Authors: Mia-Jeanne van Rooy, Wiebren Duim, Rene Ehlers, Antoinette V. Buys and Etheresia Pretorius
    Citation: Cardiovascular Diabetology 2015 14:86
  32. Diabetic patients have an increased risk of developing cardiovascular diseases, which are the leading cause of death in developed countries. Although multivitamin products are widely used as dietary supplement...

    Authors: Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy and Tamás Csont
    Citation: Cardiovascular Diabetology 2015 14:85
  33. It is not clear which glucose measure is more useful in the assessment of atherosclerosis. We investigated the associations of hemoglobin A1c (HbA1c), glycated albumin (GA), 1,5-anhydroglucitol (1,5-AG), fasting ...

    Authors: Naoko Mukai, Toshiharu Ninomiya, Jun Hata, Yoichiro Hirakawa, Fumie Ikeda, Masayo Fukuhara, Taeko Hotta, Masafumi Koga, Udai Nakamura, Dongchon Kang, Takanari Kitazono and Yutaka Kiyohara
    Citation: Cardiovascular Diabetology 2015 14:84
  34. Left ventricular (LV) diastolic dysfunction is frequently observed in patients with type 2 diabetes. Dipeptidyl peptidase-4 inhibitor (DPP-4i) attenuates postprandial hyperglycemia (PPH) and may have cardio-pr...

    Authors: Hiroki Oe, Kazufumi Nakamura, Hajime Kihara, Kenei Shimada, Shota Fukuda, Tsutomu Takagi, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2015 14:83
  35. The relationship between osteocalcin and atherosclerosis remains unclear. This might be due to different degrees of confounding from factors that are associated with serum osteocalcin level, such as metabolic-...

    Authors: Yuqi Luo, Xiaojing Ma, Yaping Hao, Qin Xiong, Yiting Xu, Xiaoping Pan, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2015 14:82
  36. Factor Xa inhibitor is used for preventing venous thromboembolism (VTE) in adult patients receiving orthopedic operation. However, the role of factor Xa inhibitor, rivaroxaban, in angiogenesis is still unknown.

    Authors: Tao-Cheng Wu, Jenq-Shyong Chan, Chiu-Yang Lee, Hsin-Bang Leu, Po-Hsun Huang, Jia-Shiong Chen, Shing-Jong Lin and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2015 14:81
  37. Patients with type 2 diabetes mellitus (DM) display a predisposition for vascular disease. Platelets taken from vasculopathic diabetic patients, show enhanced stimuli-induced activation and aggregation respons...

    Authors: Gadi Shlomai, Tal Haran-Appel, Tal Sella, Yoni Grossman, Hagit Hauschner, Nurit Rosenberg and Ehud Grossman
    Citation: Cardiovascular Diabetology 2015 14:80
  38. As a first-line diabetes drug that is widely prescribed around the world, metformin has been demonstrated to be effective in reducing microvascular risk, in addition to lowering glucose levels. Specifically, m...

    Authors: Chao Zhang, Feng Gao, Hao Luo, Chun-Ting Zhang and Ren Zhang
    Citation: Cardiovascular Diabetology 2015 14:79
  39. Glucose fluctuation has been recognized as a residual risk apart from dyslipidemia for the development of coronary artery disease (CAD). This study aimed to investigate the association between glucose fluctuat...

    Authors: Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Tsuyoshi Osue, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu and Ken-ichi Hirata
    Citation: Cardiovascular Diabetology 2015 14:78
  40. Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes. The effect of FGF21 on the development and progressio...

    Authors: Xiaoqing Yan, Jun Chen, Chi Zhang, Jun Zeng, Shanshan Zhou, Zhiguo Zhang, Xuemian Lu, Jing Chen, Wenke Feng, Xiaokun Li and Yi Tan
    Citation: Cardiovascular Diabetology 2015 14:77
  41. Both angiotensin II type 1 receptor (AT1R) and nuclear factor-kappa B (NF-κB) play significant roles in the pathogenesis of hypertension and type 2 diabetes. However, the role of NF-κB in perpetuating renal AT1 r...

    Authors: Hao Luo, Xinquan Wang, Jialiang Wang, Caiyu Chen, Na Wang, Zaicheng Xu, Shuo Chen and Chunyu Zeng
    Citation: Cardiovascular Diabetology 2015 14:76
  42. Several translational studies have identified the differential role between saturated and unsaturated fatty acids at cardiovascular level. However, the molecular mechanisms that support the protective role of ...

    Authors: Liliana Perdomo, Nuria Beneit, Yolanda F. Otero, Óscar Escribano, Sabela Díaz-Castroverde, Almudena Gómez-Hernández and Manuel Benito
    Citation: Cardiovascular Diabetology 2015 14:75
  43. There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis ...

    Authors: Sang-Hoon Kim, Jae-Youn Moon, Yeong Min Lim, Kyung Ho Kim, Woo-In Yang, Jung-Hoon Sung, Seung Min Yoo, In Jai Kim, Sang-Wook Lim, Dong-Hun Cha and Seung-Yun Cho
    Citation: Cardiovascular Diabetology 2015 14:74
  44. Fibroblast growth factor 21 (FGF21), a glucose and lipid metabolic regulator, has recently been demonstrated to be associated with cardiovascular diseases (CVD) such as carotid atherosclerosis, coronary heart ...

    Authors: Yang Xiao, Lingjiao Liu, Aimin Xu, Pengcheng Zhou, Zhaofeng Long, Yiting Tu, Xiaoyan Chen, Weili Tang, Gan Huang and Zhiguang Zhou
    Citation: Cardiovascular Diabetology 2015 14:72
  45. Type 1 diabetes is associated with raised inflammation, impaired endothelial progenitor cell mobilisation and increased markers of vascular injury. Both acute and chronic exercise is known to influence these m...

    Authors: Daniel J West, Matthew D Campbell, Javier T Gonzalez, Mark Walker, Emma J Stevenson, Fahad W Ahmed, Stephanie Wijaya, James A Shaw and Jolanta U Weaver
    Citation: Cardiovascular Diabetology 2015 14:71
  46. It is presently unclear whether glycemic variability is associated with diabetic cardiovascular autonomic neuropathy (CAN). The aim of this study was to examine whether short- and/or long-term glycemic variabi...

    Authors: Ji Eun Jun, Sang-Man Jin, Jongha Baek, Sewon Oh, Kyu Yeon Hur, Myung-Shik Lee, Moon-Kyu Lee and Jae Hyeon Kim
    Citation: Cardiovascular Diabetology 2015 14:70

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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