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  1. Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-te...

    Authors: Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Xiao-Lin Li, Chuan-Jue Cui, Geng Liu, Jing Sun…

    Citation: Cardiovascular Diabetology 2020 19:152

    Content type: Original investigation

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  2. Previous meta-analyses have suggested that diabetes confers a greater excess risk of coronary heart disease, stroke, vascular dementia, and heart failure in women compared to men. While the underlying mechanis...

    Authors: Alyssa Z. Chase-Vilchez, Isaac H. Y. Chan, Sanne A. E. Peters and Mark Woodward

    Citation: Cardiovascular Diabetology 2020 19:151

    Content type: Review

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  3. Metformin has been shown to have both neuroprotective and neurodegenerative effects. The aim of this study was to investigate the effect of metformin in combination with insulin on cardiovascular autonomic neu...

    Authors: Christian Stevns Hansen, Louise Lundby-Christiansen, Lise Tarnow, Christian Gluud, Christoffer Hedetoft, Birger Thorsteinsson, Bianca Hemmingsen, Niels Wiinberg, Simone B. Sneppen, Søren S. Lund, Thure Krarup, Sten Madsbad, Thomas Almdal, Bendix Carstensen and Marit E. Jørgensen

    Citation: Cardiovascular Diabetology 2020 19:150

    Content type: Original investigation

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  4. Statins suppress the progression of atherosclerosis by reducing low-density lipoprotein (LDL) cholesterol levels. Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modulator, ...

    Authors: Masatoki Yoshida, Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Megumi Kondo, Kaoru Akazawa, Tomonari Kimura, Hiroaki Ohtsuka, Yuko Ohno, Daiji Miura and Hiroshi Ito

    Citation: Cardiovascular Diabetology 2020 19:149

    Content type: Original investigation

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  5. Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noni...

    Authors: Wataru Shimizu, Yoshiaki Kubota, Yu Hoshika, Kosuke Mozawa, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu-ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Masahiro Ishikawa…

    Citation: Cardiovascular Diabetology 2020 19:148

    Content type: Original investigation

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  6. Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse...

    Authors: Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Nicola Bonadia, Piergiorgio Bruno, Flavia Angelini, Carmine Di Stasi, Andrea Contegiacomo, Angelo Santoliquido, Dario Pitocco, Raffaele Landolfi and Andrea Flex

    Citation: Cardiovascular Diabetology 2020 19:147

    Content type: Original investigation

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  7. Glycemic variability (GV) confers a risk of cardiovascular events. In this study, we aimed to investigate whether long-term GV has an impact on coronary atherosclerosis progression in patients with type 2 diab...

    Authors: Suhua Li, Xixiang Tang, Yanting Luo, Bingyuan Wu, Zhuoshan Huang, Zexiong Li, Long Peng, Yesheng Ling, Jieming Zhu, Junlin Zhong, Jinlai Liu and Yanming Chen

    Citation: Cardiovascular Diabetology 2020 19:146

    Content type: Original investigation

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  8. Inflamed visceral adipose tissue (VAT) facilitates chronic inflammation in atherosclerotic lesions thereby leading to increased risk of coronary artery disease (CAD). In this study, we evaluated the glucose up...

    Authors: Kisoo Pahk, Eung Ju Kim, Chanmin Joung, Hong Seog Seo and Sungeun Kim

    Citation: Cardiovascular Diabetology 2020 19:145

    Content type: Original investigation

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  9. Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed several limitations. We investigated whether variability in lo...

    Authors: Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park and Nan Hee Kim

    Citation: Cardiovascular Diabetology 2020 19:144

    Content type: Original investigation

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  10. This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker of arterial stiffness for the prediction of all-cause and cause-specific mortality in patients wit...

    Authors: Jeong Mi Kim, Sang Soo Kim, In Joo Kim, Jong Ho Kim, Bo Hyun Kim, Mi Kyung Kim, Soon Hee Lee, Chang Won Lee, Min Chul Kim, Jun Hyeob Ahn and Jinmi Kim

    Citation: Cardiovascular Diabetology 2020 19:143

    Content type: Original investigation

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  11. Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. ...

    Authors: Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa and Toshihisa Anzai

    Citation: Cardiovascular Diabetology 2020 19:142

    Content type: Original investigation

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  12. Lower limb arterial calcification is a frequent, underestimated but serious complication of diabetes. The DIACART study is a prospective cohort study designed to evaluate the determinants of the progression of...

    Authors: Olivier Bourron, Franck Phan, Mamadou Hassimiou Diallo, David Hajage, Carole-Elodie Aubert, Aurélie Carlier, Joe-Elie Salem, Christian Funck-Brentano, Salim Kemel, Philippe Cluzel, Alban Redheuil, Jean-Michel Davaine, Ziad Massy, Romuald Mentaverri, Dominique Bonnefont-Rousselot, Philippe Gillery…

    Citation: Cardiovascular Diabetology 2020 19:140

    Content type: Original investigation

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  13. Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stif...

    Authors: Minghui Li, Aihua Zhan, Xiao Huang, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao and Xiaoshu Cheng

    Citation: Cardiovascular Diabetology 2020 19:139

    Content type: Original investigation

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  14. High body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associati...

    Authors: Chen Botvin Moshe, Salo Haratz, Ramit Ravona-Springer, Anthony Heymann, Lin Hung-Mo, Michal Schnaider Beeri and David Tanne

    Citation: Cardiovascular Diabetology 2020 19:138

    Content type: Original investigation

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  15. Triglyceride Glucose (TyG) index has been associated with an increased risk in cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country...

    Authors: Pham Viet Thai, Hoang Anh Tien, Huynh Van Minh and Paul Valensi

    Citation: Cardiovascular Diabetology 2020 19:137

    Content type: Original investigation

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  16. The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of nor...

    Authors: Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen and Modar Kassan

    Citation: Cardiovascular Diabetology 2020 19:136

    Content type: Review

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  17. Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved in plaque destabilization. Atherosclerosis has been known to be progressive in patients with type 2 diabetes mellitus (DM). T...

    Authors: Takaaki Kogo, Takafumi Hiro, Daisuke Kitano, Tadateru Takayama, Daisuke Fukamachi, Tomoyuki Morikawa, Mitsumasa Sudo and Yasuo Okumura

    Citation: Cardiovascular Diabetology 2020 19:135

    Content type: Original investigation

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  18. The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well established. Early in the course of the diabetic disease, some degree of impaired exercise capacity (a powerful marker of ...

    Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto and Andrea Natali

    Citation: Cardiovascular Diabetology 2020 19:134

    Content type: Commentary

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  19. Patients with type 2 diabetes are under substantially higher risk of in-stent restenosis (ISR) after coronary stent implantation. We sought to investigate whether visit-to-visit HbA1c variability is a potential p...

    Authors: Chen Die Yang, Ying Shen, Lin Lu, Zhen Kun Yang, Jian Hu, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding and Xiao Qun Wang

    Citation: Cardiovascular Diabetology 2020 19:133

    Content type: Original investigation

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  20. Patients with type 2 diabetes mellitus (T2DM) are predisposed to poor cardiovascular outcomes after ST-segment elevation myocardial infarction (STEMI). Left ventricular adverse remodeling (LVAR) triggered upon...

    Authors: Chen Die Yang, Ying Shen, Feng Hua Ding, Zhen Kun Yang, Jian Hu, Wei Feng Shen, Rui Yan Zhang, Lin Lu and Xiao Qun Wang

    Citation: Cardiovascular Diabetology 2020 19:131

    Content type: Original investigation

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  21. Type 2 diabetes is closely related to an increased risk of atrial fibrillation (AF) and atrial flutter (AFL). Whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can attenuate AF/AFL progression remains ...

    Authors: Wen-jie Li, Xing-qing Chen, Ling-ling Xu, Yuan-qing Li and Bi-hui Luo

    Citation: Cardiovascular Diabetology 2020 19:130

    Content type: Review

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  22. Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diast...

    Authors: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer and Tineke van de Weijer

    Citation: Cardiovascular Diabetology 2020 19:129

    Content type: Original investigation

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  23. Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes ...

    Authors: Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou and Fang Fang

    Citation: Cardiovascular Diabetology 2020 19:128

    Content type: Original investigation

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  24. The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. There...

    Authors: Lauren L. O’Mahoney, Gareth Dunseath, Rachel Churm, Mel Holmes, Christine Boesch, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Karen M. Birch, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price and Matthew D. Campbell

    Citation: Cardiovascular Diabetology 2020 19:127

    Content type: Original investigation

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  25. Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed...

    Authors: Antonio J. Amor, Esmeralda Castelblanco, Marta Hernández, Marga Gimenez, Minerva Granado-Casas, Jesús Blanco, Berta Soldevila, Enric Esmatjes, Ignacio Conget, Nuria Alonso, Emilio Ortega and Didac Mauricio

    Citation: Cardiovascular Diabetology 2020 19:126

    Content type: Original investigation

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  26. Adiponectin plays role in multiple metabolic pathways. Previous studies in cardiovascular disease evaluated the association between adiponectin and clinical outcomes, yielding conflicting results. The aim of t...

    Authors: Wen-Jun Tu, Han-Cheng Qiu, Ya-Kun Liu, Qiang Liu, Xianwei Zeng and Jizong Zhao

    Citation: Cardiovascular Diabetology 2020 19:125

    Content type: Original investigation

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  27. Observational series suggest a mortality benefit from metformin in the heart failure (HF) population. However, the benefit of metformin in HF with preserved ejection fraction (HFpEF) has yet to be explored. We...

    Authors: Amera Halabi, Jonathan Sen, Quan Huynh and Thomas H. Marwick

    Citation: Cardiovascular Diabetology 2020 19:124

    Content type: Original investigation

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  28. Ferritin, a crucial element for iron homeostasis, is associated with chronic diseases characterized by subclinical inflammation such as essential arterial hypertension and type 2 diabetes mellitus (T2DM), show...

    Authors: Angela Sciacqua, Ettore Ventura, Giovanni Tripepi, Velia Cassano, Graziella D’Arrigo, Stefanos Roumeliotis, Raffale Maio, Sofia Miceli, Maria Perticone, Francesco Andreozzi, Giorgio Sesti and Francesco Perticone

    Citation: Cardiovascular Diabetology 2020 19:123

    Content type: Original investigation

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  29. Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothe...

    Authors: Laure Alexandre-Heymann, Matthias Barral, Anthony Dohan and Etienne Larger

    Citation: Cardiovascular Diabetology 2020 19:122

    Content type: Original investigation

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  30. Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic p...

    Authors: Huajie Zou, Yongping Xu, Xi Chen, Ping Yin, Danpei Li, Wenjun Li, Junhui Xie, Shiying Shao, Liegang Liu and Xuefeng Yu

    Citation: Cardiovascular Diabetology 2020 19:121

    Content type: Original investigation

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  31. Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investig...

    Authors: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen and Hong-Bin Liu

    Citation: Cardiovascular Diabetology 2020 19:120

    Content type: Original investigation

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  32. Diabetes mellitus is one of the risk factors for coronary artery disease and frequently associated with multivessels disease and poor clinical outcomes. Long term outcome of successful revascularization of chr...

    Authors: Chuan-Tsai Tsai, Wei-Chieh Huang, Hsin-I Teng, Yi-Lin Tsai and Tse-Min Lu

    Citation: Cardiovascular Diabetology 2020 19:119

    Content type: Original investigation

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  33. Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...

    Authors: Heng Wan, Yuying Wang, Qian Xiang, Sijie Fang, Yi Chen, Chi Chen, Wen Zhang, Haojie Zhang, Fangzhen Xia, Ningjian Wang and Yingli Lu

    Citation: Cardiovascular Diabetology 2020 19:118

    Content type: Original investigation

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  34. Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigat...

    Authors: Beatrice von Jeinsen, Lisa Ritzen, Julia Vietheer, Claudia Unbehaun, Maren Weferling, Christoph Liebetrau, Christian W. Hamm, Andreas Rolf and Till Keller

    Citation: Cardiovascular Diabetology 2020 19:117

    Content type: Original investigation

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  35. Previous studies have investigated the relationship of the triglyceride glucose (TyG) index with the incidence of cardiovascular events. However, to date, there have been no studies comparing the predictive va...

    Authors: Chengping Hu, Jianwei Zhang, Jinxing Liu, Yan Liu, Ang Gao, Yong Zhu and Yingxin Zhao

    Citation: Cardiovascular Diabetology 2020 19:116

    Content type: Original investigation

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  36. The coronavirus disease 2019 (COVID-19) has been declared as pandemic by the World Health Organization and is causing substantial morbidity and mortality all over the world. Type 2 diabetes, hypertension, and ...

    Authors: Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito

    Citation: Cardiovascular Diabetology 2020 19:115

    Content type: Commentary

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  37. In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

    Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi

    Citation: Cardiovascular Diabetology 2020 19:114

    Content type: Review

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  38. The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using s...

    Authors: Ki-Bum Won, Byoung Kwon Lee, Hyung-Bok Park, Ran Heo, Sang-Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb…

    Citation: Cardiovascular Diabetology 2020 19:113

    Content type: Original investigation

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  39. Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to in...

    Authors: Binruo Zhu, Jie Wang, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen and Yiming Mu

    Citation: Cardiovascular Diabetology 2020 19:112

    Content type: Original investigation

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  40. Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance ...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu and Jian-Jun Li

    Citation: Cardiovascular Diabetology 2020 19:111

    Content type: Original investigation

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  41. This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type 2 diabetes (T2DM) patients without ...

    Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…

    Citation: Cardiovascular Diabetology 2020 19:110

    Content type: Original investigation

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  42. Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident...

    Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu

    Citation: Cardiovascular Diabetology 2020 19:109

    Content type: Original investigation

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  43. The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index ...

    Authors: Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang and Yu-Jie Zhou

    Citation: Cardiovascular Diabetology 2020 19:108

    Content type: Original investigation

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  44. In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) ...

    Authors: David Thein, Mia Nielsen Christiansen, Ulrik Madvig Mogensen, Johan Skov Bundgaard, Rasmus Rørth, Christian Madelaire, Emil Loldrup Fosbøl, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Lars Køber and Søren Lund Kristensen

    Citation: Cardiovascular Diabetology 2020 19:107

    Content type: Original investigation

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  45. To assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c ...

    Authors: Chen-Yi Yang, Pei-Fang Su, Jo-Ying Hung, Huang-Tz Ou and Shihchen Kuo

    Citation: Cardiovascular Diabetology 2020 19:105

    Content type: Original investigation

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  46. The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed...

    Authors: Ye-Xuan Cao, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yan Zhang, Ying Gao, Yuan-Lin Guo, Na-Qiong Wu, Qi Hua, Yan-Fang Li, Xiao-Lin Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun…

    Citation: Cardiovascular Diabetology 2020 19:104

    Content type: Original investigation

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  47. Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcom...

    Authors: Jiewen Jin, Zhantao Deng, Lijuan Xu, Hai Li, Pengyuan Zhang, Liehua Liu, Juan Liu, Hedong Han, Zhimin Huang, Xiaopei Cao, Haipeng Xiao and Yanbing Li

    Citation: Cardiovascular Diabetology 2020 19:103

    Content type: Original investigation

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