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  1. Lack of suitable mouse models has hindered the studying of diabetic macrovascular complications. We examined the effects of type 2 diabetes on coronary artery disease and cardiac function in hypercholesterolem...

    Authors: Suvi E Heinonen, Mari Merentie, Marja Hedman, Petri I Mäkinen, Elina Loponen, Ivana Kholová, Fatima Bosch, Markku Laakso and Seppo Ylä-Herttuala
    Citation: Cardiovascular Diabetology 2011 10:59
    Content type: Original investigation Published on:

  2. Although the ADA/EASD/IDF International Expert Committee recommends using hemoglobin A1c (HbA1c) to define diabetes, the relation between HbA1c and cardiovascular disease (CVD) has not been thoroughly investig...

    Authors: Rimei Nishimura, Tomoko Nakagami, Hirohito Sone, Yasuo Ohashi and Naoko Tajima
    Citation: Cardiovascular Diabetology 2011 10:58
    Content type: Original investigation Published on:

  3. Diabetic cardiomyopathy, a diabetes-specific complication, refers to a disorder that eventually leads to left ventricular hypertrophy in addition to diastolic and systolic dysfunction. In recent studies, hyper...

    Authors: Po-Ming Ku, Li-Jen Chen, Jia-ru Liang, Kai-Chun Cheng, Yin-Xiao Li and Juei-Tang Cheng
    Citation: Cardiovascular Diabetology 2011 10:57
    Content type: Original investigation Published on:

  4. Diabetes mellitus type 2 (DM2) is a risk factor for coronary heart disease (CHD). While there is a clear correlation of fasting blood glucose (FBG) and 2 h post-challenge blood glucose values (2h-BG) with micr...

    Authors: Sven Schinner, Reiner Füth, Kerstin Kempf, Stephan Martin, Holger S Willenberg, Matthias Schott, Wilfried Dinh, Werner A Scherbaum and Mark Lankisch
    Citation: Cardiovascular Diabetology 2011 10:56
    Content type: Original investigation Published on:

  5. Type 2 diabetes is associated with increased levels of Angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2), but its impact on vascular disease is still unknown. This study aimed to further explore the associatio...

    Authors: Sazan Rasul, Marie Helene Reiter, Aysegul Ilhan, Katharina Lampichler, Ludwig Wagner and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2011 10:55
    Content type: Original investigation Published on:

  7. Type 1 diabetes mellitus is a generally accepted atherogenic risk factor. The aim of this prospective longitudinal study was to evaluate changes in carotid intima media thickness (cIMT) in children and adolesc...

    Authors: Robert Dalla Pozza, Andreas Beyerlein, Claude Thilmany, Claudia Weissenbacher, Heinrich Netz, Heinrich Schmidt and Susanne Bechtold
    Citation: Cardiovascular Diabetology 2011 10:53
    Content type: Original investigation Published on:

  8. To assess the impact of long-term oral nitrate therapy on clinical outcome following percutaneous coronary intervention (PCI) in patients with type II diabetes.

    Authors: Kai Hang Yiu, Vincent Pong, Chung Wah Siu, Chu Pak Lau and Hung Fat Tse
    Citation: Cardiovascular Diabetology 2011 10:52
    Content type: Original investigation Published on:

  9. High sensitivity C-reactive protein (hsCRP) is an acute phase reactant and a sensitive marker of inflammation. Hyperglycemia can potentially promote the production of CRP. The aim of this study was to determin...

    Authors: Ryuichi Kawamoto, Yasuharu Tabara, Katsuhiko Kohara, Tetsuro Miki, Tomo Kusunoki, Shuzo Takayama, Masanori Abe, Tateaki Katoh and Nobuyuki Ohtsuka
    Citation: Cardiovascular Diabetology 2011 10:51
    Content type: Original investigation Published on:

  10. It has been shown that dendritic cells (DCs) and fractalkine play a role in accelerating progression of the inflamed atherosclerotic lesions and plaque rupture. We evaluated the numbers and functional changes ...

    Authors: Kang Yao, Hao Lu, Rongchong Huang, Shuning Zhang, Xiaowu Hong, Hongyu Shi, Aijun Sun, Juying Qian, Yunzeng Zou and Junbo Ge
    Citation: Cardiovascular Diabetology 2011 10:50
    Content type: Original investigation Published on:

  11. Authors: Lucinara D Dias, Karina R Casali, Natalia M Leguisamo, Felipe Azambuja, Martina S Souza, Maristela Okamoto, Ubiratan F Machado, Maria Cláudia Irigoyen and Beatriz D Schaan
    Citation: Cardiovascular Diabetology 2011 10:49
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2011 10:33

  12. Insulin resistance, diabetes, and hypertension are considered elements of metabolic syndrome which is associated with vascular dysfunction. We investigated whether inhibition of protein kinase C (PKC) would af...

    Authors: Xiao Lu, James S Bean, Ghassan S Kassab and Mark D Rekhter
    Citation: Cardiovascular Diabetology 2011 10:48
    Content type: Original investigation Published on:

  13. Increased cardiac lipid content has been associated with diabetic cardiomyopathy. We recently showed that cardiac lipid content is reduced after 12 weeks of physical activity training in healthy overweight sub...

    Authors: Vera B Schrauwen-Hinderling, Ruth CR Meex, Matthijs KC Hesselink, Tineke van de Weijer, Tim Leiner, Michael Schär, Hildo J Lamb, Joachim E Wildberger, Jan FC Glatz, Patrick Schrauwen and M Eline Kooi
    Citation: Cardiovascular Diabetology 2011 10:47
    Content type: Original investigation Published on:

  14. Non-high-density lipoprotein cholesterol (non-HDL-C) measures all atherogenic apolipoprotein B-containing lipoproteins and predicts risk of cardiovascular diseases (CVD). The association of non-HDL-C with risk...

    Authors: Chaoyang Li, Earl S Ford, James Tsai, Guixiang Zhao, Lina S Balluz and Samuel S Gidding
    Citation: Cardiovascular Diabetology 2011 10:46
    Content type: Original investigation Published on:

  15. Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan. While numerous clinical trials have indicated important...

    Authors: Yasuo Takahashi, Yayoi Nishida, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2011 10:45
    Content type: Original investigation Published on:

  16. Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently as...

    Authors: Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2011 10:44
    Content type: Original investigation Published on:

  17. Platelet hyperaggregability is a pro-thrombotic feature of type-2 diabetes, associated with low levels of the antioxidant glutathione (GSH). Clinical delivery of N-acetylcysteine (NAC), a biosynthetic precursor o...

    Authors: Kyle R Gibson, Tim J Winterburn, Fiona Barrett, Sushma Sharma, Sandra M MacRury and Ian L Megson
    Citation: Cardiovascular Diabetology 2011 10:43
    Content type: Original investigation Published on:

  18. Metabolic syndrome (MS) is a metabolic disorder associated with obesity, type-II diabetes, and "low grade inflammation", with the concomitant increased risk of cardiovascular events. Removal of the inflammator...

    Authors: Leticia Martín-Cordero, Juan J García, Maria D Hinchado and Eduardo Ortega
    Citation: Cardiovascular Diabetology 2011 10:42
    Content type: Original investigation Published on:

  19. Myeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves...

    Authors: Wen Hui Peng, Wei Xia Jian, Hai Ling Li, Lei Hou, Yi Dong Wei, Wei Ming Li and Ya Wei Xu
    Citation: Cardiovascular Diabetology 2011 10:41
    Content type: Original investigation Published on:

  20. Type 2 diabetes is an important risk factor for the development of coronary artery disease (CAD). Focal or diffuse inflammation is often present in the vessels of patients with CAD. Mast cells are frequently p...

    Authors: Aleš Pleskovič, Olga Vraspir-Porenta, Ruda Zorc-Pleskovič, Danijel Petrovič, Metka Zorc and Aleksandra Milutinović
    Citation: Cardiovascular Diabetology 2011 10:40
    Content type: Original investigation Published on:

  21. Patients with type 2 diabetes mellitus and heart failure have adverse clinical outcomes, but the characteristics and prognosis of those with undiagnosed diabetes in this setting has not been established.

    Authors: Juana A Flores-Le Roux, Josep Comin, Juan Pedro-Botet, David Benaiges, Jaume Puig-de Dou, Juan J Chillarón, Alberto Goday, Jordi Bruguera and Juan F Cano-Perez
    Citation: Cardiovascular Diabetology 2011 10:39
    Content type: Original investigation Published on:

  23. Heart type fatty acid binding protein (H-FABP) has been closely associated with acute coronary syndrome, cardiac abnormalities, stroke, and obstructive sleep disorder in previous studies. The aim of this study...

    Authors: Basak Karbek, Mustafa Özbek, Nujen Colak Bozkurt, Zeynep Ginis, Askın Güngünes, İlknur Öztürk Ünsal, Erman Cakal and Tuncay Delibası
    Citation: Cardiovascular Diabetology 2011 10:37
    Content type: Original investigation Published on:

  24. Leptin is associated with cardiovascular disease (CVD); however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population. Therefore, the aim of the present study w...

    Authors: Wen-Cheng Li, Kuang-Yu Hsiao, I-Chuan Chen, Yu-Che Chang, Shih-Hao Wang and Kuan-Han Wu
    Citation: Cardiovascular Diabetology 2011 10:36
    Content type: Original investigation Published on:

  25. Changes in the proteoglycans glypican and syndecan-4 have been reported in several pathological conditions, but little is known about their expression in the heart during diabetes. The aim of this study was to...

    Authors: Célia MC Strunz, Monique Matsuda, Vera MC Salemi, Adriana Nogueira, Antonio P Mansur, Ismar N Cestari and Monica V Marquezini
    Citation: Cardiovascular Diabetology 2011 10:35
    Content type: Original investigation Published on:

  26. Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated...

    Authors: Kei Nakajima, Tohru Nemoto, Toshitaka Muneyuki, Masafumi Kakei, Hiroshi Fuchigami and Hiromi Munakata
    Citation: Cardiovascular Diabetology 2011 10:34
    Content type: Original investigation Published on:

  27. The effects of renal denervation on cardiovascular reflexes and markers of nephropathy in diabetic-hypertensive rats have not yet been explored.

    Authors: Lucinara D Dias, Karina R Casali, Natalia M Leguisamo, Felipe Azambuja, Martina S Souza, Maristela Okamoto, Ubiratan F Machado, Maria Cláudia Irigoyen and Beatriz D Schaan
    Citation: Cardiovascular Diabetology 2011 10:33
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2011 10:49

  28. Coronary artery disease (CAD) and stroke share a major linkage at the chromosome 12q24 locus. The same chromosome region entails at least a major risk gene for type 2 diabetes (T2D) within NIDDM2, the non-insu...

    Authors: Claudia Gragnoli
    Citation: Cardiovascular Diabetology 2011 10:32
    Content type: Original investigation Published on:

  29. For patients with diabetes, clinical practice guidelines recommend treating to a low-density lipoprotein cholesterol (LDL-C) goal of <2.59 mmol/L (100 mg/dL) and a blood pressure (BP) target of <130/80 mmHg. T...

    Authors: Andreas Kuznik and Jack Mardekian
    Citation: Cardiovascular Diabetology 2011 10:31
    Content type: Original investigation Published on:

  30. Increased fasting plasma glucose (FPG), which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for arterial stiffness. While IFG is widely accepted as a...

    Authors: Jin Young Shin, Hye Ree Lee and Duk Chul Lee
    Citation: Cardiovascular Diabetology 2011 10:30
    Content type: Original investigation Published on:

  31. Left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular disease and is common among patients with type 2 diabetes. However, no systematic screening for LVH is currently recommended for patie...

    Authors: Jithendra B Somaratne, Gillian A Whalley, Katrina K Poppe, Mariska M ter Bals, Gina Wadams, Ann Pearl, Warwick Bagg and Rob N Doughty
    Citation: Cardiovascular Diabetology 2011 10:29
    Content type: Original investigation Published on:

  32. N-terminal-pro-brain natriuretic peptide (NT-proBNP) is elevated in gestational hypertension and preeclampsia. This trial aimed to generate data for gestational diabetes mellitus patients, who are at risk to d...

    Authors: Martin Andreas, Harald Zeisler, Ammon Handisurya, Maximilian B Franz, Michael Gottsauner-Wolf, Michael Wolzt and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2011 10:28
    Content type: Original investigation Published on:

  33. Several studies have shown that common variants in the MTNR1B gene were associated with fasting glucose level and type 2 diabetes. The purpose of this study was to examine whether tagging single nucleotide polymo...

    Authors: Yan Ling, Xiaomu Li, Qian Gu, Hongyan Chen, Daru Lu and Xin Gao
    Citation: Cardiovascular Diabetology 2011 10:27
    Content type: Original investigation Published on:

  34. Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction (MI), in experimental studies disagreement exists about the sensitivity to ischemic injury of an infarcted myocardi...

    Authors: Bruno Rodrigues, Kaleizu T Rosa, Alessandra Medeiros, Beatriz D Schaan, Patricia C Brum, Kátia De Angelis and Maria Cláudia Irigoyen
    Citation: Cardiovascular Diabetology 2011 10:26
    Content type: Original investigation Published on:

  35. Aspirin has been recommended for the prevention of major adverse cardiovascular events (MACE, composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) in diabetic patients with...

    Authors: Sonia Butalia, Alexander A Leung, William A Ghali and Doreen M Rabi
    Citation: Cardiovascular Diabetology 2011 10:25
    Content type: Review Published on:

  36. Hypertension, diabetes and obesity are not isolated findings, but a series of interacting interactive physiologic derangements. Taking into account genetic background and lifestyle behavior, AI (autonomic imba...

    Authors: Leandro Boer-Martins, Valéria N Figueiredo, Caroline Demacq, Luiz C Martins, Fernanda Consolin-Colombo, Márcio J Figueiredo, Fernando PS Cannavan and Heitor Moreno Jr
    Citation: Cardiovascular Diabetology 2011 10:24
    Content type: Original investigation Published on:

  37. Increased plasma plasminogen activator inhibitor-1 (PAI-1) activity and decreased tissue plasminogen activator (tPA) activity could be considered a true component of the metabolic syndrome (MetS) associated wi...

    Authors: Zaid Al-Hamodi, Ikram S Ismail, Riyadh Saif-Ali, Khaled A Ahmed and Sekaran Muniandy
    Citation: Cardiovascular Diabetology 2011 10:23
    Content type: Original investigation Published on:

  38. It is important for patients that treatments for diabetes not increase cardiovascular (CV) risk. The objective of this analysis was to examine retrospectively the CV safety of exenatide BID, a GLP-1 receptor a...

    Authors: Robert Ratner, Jenny Han, Dawn Nicewarner, Irina Yushmanova, Byron J Hoogwerf and Larry Shen
    Citation: Cardiovascular Diabetology 2011 10:22
    Content type: Original investigation Published on:

  39. Although European guidelines advise oral glucose tolerance test (OGTT) in patients with acute myocardial infarction (AMI) before or shortly after hospital discharge, data supporting this recommendation are inc...

    Authors: Agata Bronisz, Marek Kozinski, Przemyslaw Magielski, Tomasz Fabiszak, Joanna Gierach, Iwona Swiatkiewicz, Adam Sukiennik, Aldona Kubica, Marek Bronisz, Zofia Grabczewska, Anna Sinkiewicz, Roman Junik and Jacek Kubica
    Citation: Cardiovascular Diabetology 2011 10:21
    Content type: Original investigation Published on:

  40. Apolipoprotein B100 (apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high corre...

    Authors: Michel P Hermans, Frank M Sacks, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2011 10:20
    Content type: Original investigation Published on:

  41. Glucose variability is one of components of the dysglycemia in diabetes and may play an important role in development of diabetic vascular complications. The objective of this study was to assess the relations...

    Authors: Gong Su, Shuhua Mi, Hong Tao, Zhao Li, Hongxia Yang, Hong Zheng, Yun Zhou and Changsheng Ma
    Citation: Cardiovascular Diabetology 2011 10:19
    Content type: Original investigation Published on:

  42. Type 2 diabetes (T2D) is strongly associated with cardiovascular risk and requires medications that improve glycemic control and other cardiovascular risk factors. The authors aimed to assess the relative effe...

    Authors: Ángel Rodríguez, Jesús Reviriego, Vasilios Karamanos, Francisco J del Cañizo, Nikolaos Vlachogiannis and Vangelis Drossinos
    Citation: Cardiovascular Diabetology 2011 10:18
    Content type: Original investigation Published on:

  43. The biological mechanisms in the association between the metabolic syndrome (MS) and various biomarkers, such as 25-hydroxyvitamin D (vit D) and magnesium, are not fully understood. Several of the proposed pre...

    Authors: Jo Røislien, Ben Van Calster and Jøran Hjelmesæth
    Citation: Cardiovascular Diabetology 2011 10:17
    Content type: Original investigation Published on:

  44. Elevated plasma levels of asymmetric dimethylarginine (ADMA) has been reported to be associated with insulin resistance and micro/macrovascular diabetic complications, and may predict cardiovascular events in ...

    Authors: Tse-Min Lu, Shing-Jong Lin, Ming-Wei Lin, Chiao-Po Hsu and Ming-Yi Chung
    Citation: Cardiovascular Diabetology 2011 10:16
    Content type: Original investigation Published on:

  45. To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function.

    Authors: Frank Edelmann, Rolf Wachter, Hans-Dirk Düngen, Stefan Störk, Annette Richter, Raoul Stahrenberg, Till Neumann, Claus Lüers, Christiane E Angermann, Felix Mehrhof, Götz Gelbrich and Burkert Pieske
    Citation: Cardiovascular Diabetology 2011 10:15
    Content type: Original investigation Published on:

  46. Adiponectin has insulin-sensitizing and anti-atherosclerotic effects, partly mediated through its action on monocytes. We aimed to determine adiponectin levels and expression of its receptors (AdipoR1 and Adip...

    Authors: Anastasios Kollias, Panayoula C Tsiotra, Ignatios Ikonomidis, Eirini Maratou, Panayota Mitrou, Erifyli Kyriazi, Eleni Boutati, John Lekakis, Theofanis Economopoulos, Dimitrios T Kremastinos, George Dimitriadis and Sotirios A Raptis
    Citation: Cardiovascular Diabetology 2011 10:14
    Content type: Original investigation Published on:

  48. Diabetes mellitus has emerged as one of the main alarms to human health in the 21st century. Pronounced changes in the human environment, behavior and lifestyle have accompanied globalization, which resulted i...

    Authors: Edite Teixeira-Lemos, Sara Nunes, Frederico Teixeira and Flávio Reis
    Citation: Cardiovascular Diabetology 2011 10:12
    Content type: Review Published on:

  50. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist rosiglitazone has been suggested to exert cardiovascular protection through the improvement of lipid metabolism, anti-inflammation, anti-prolife...

    Authors: Liqun Ren, Naifeng Liu, Hong Zhi, Yingjuan Li, Yanzhi Li, Rining Tang and Zulong Sheng
    Citation: Cardiovascular Diabetology 2011 10:10
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

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