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  1. Content type: Original investigation

    Systemic adiponectin is reduced in patients with cardiovascular disease (CVD) and low adiponectin may contribute to the pathogenesis of atherosclerosis. However, circulating adiponectin is elevated in type 1 d...

    Authors: Sabine Abke, Markus Neumeier, Johanna Weigert, Gabriele Wehrwein, Elke Eggenhofer, Andreas Schäffler, Kevin Maier, Charalampos Aslanidis, Jürgen Schölmerich and Christa Buechler

    Citation: Cardiovascular Diabetology 2006 5:17

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  2. Content type: Methodology

    Secondary treatment of arteriosclerosis may be applicable for the primary prevention of atherosclerosis in diabetic patients. This prospective, 2-year follow-up study was designed to determine the efficacy and...

    Authors: Yoshimitsu Yamasaki, Young-Seol Kim and Ryuzo Kawamori

    Citation: Cardiovascular Diabetology 2006 5:16

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  3. Content type: Original investigation

    Coronary artery disease is the leading cause of death in industrialized countries and most patients with diabetes die from complications of atherosclerosis. The objective of this study was to determine the pre...

    Authors: Alireza Esteghamati, Mehrshad Abbasi, Manouchehr Nakhjavani, Abbas Yousefizadeh, Amelita P Basa and Hamid Afshar

    Citation: Cardiovascular Diabetology 2006 5:15

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  4. Content type: Original investigation

    Tumor necrosis factor-α (TNFα) is a mediator of insulin resistance. Plasma levels of soluble TNFα receptors (sTNFR1 and sTNFR2) probably reflect paracrine action of the cytokine. TNFα is also a regulator of li...

    Authors: Marek Straczkowski, Irina Kowalska, Agnieszka Nikolajuk, Agnieszka Adamska, Malgorzata Karolczuk-Zarachowicz, Monika Karczewska-Kupczewska, Agnieszka Kozlowska and Maria Gorska

    Citation: Cardiovascular Diabetology 2006 5:14

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  5. Content type: Original investigation

    Foam cell formation in diabetic patients often occurs in the presence of high insulin and glucose levels. To test whether hyperinsulinemic hyperglycemic conditions affect foam cell differentiation, we examined...

    Authors: Pavel N Shashkin, Nitin Jain, Yury I Miller, Benjamin A Rissing, Yuqing Huo, Susanna R Keller, George E Vandenhoff, Jerry L Nadler and Thomas M McIntyre

    Citation: Cardiovascular Diabetology 2006 5:13

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  6. Content type: Original investigation

    Adiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine. These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2.

    Authors: Uli C Broedl, Michael Lehrke, Elisabeth Fleischer-Brielmaier, Anne B Tietz, Jutta M Nagel, Burkhard Göke, Peter Lohse and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2006 5:11

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  7. Content type: Original investigation

    South-Asians have lower adiponectin levels compared to Caucasians. It was not clear however, if this intrinsic feature is related to aspects of glucose metabolism. This study aims to determine the relationship...

    Authors: Hanif Wasim, Nasser M Al-Daghri, Raja Chetty, Phillip G McTernan, A H Barnett and Sudhesh Kumar

    Citation: Cardiovascular Diabetology 2006 5:10

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  8. Content type: Original investigation

    Impaired glucose tolerance (IGT) is associated with increased cardiovascular risk. The pathophysiological mechanisms linking post-challenge hyperglycemia to accelerated atherosclerosis, however remain to be el...

    Authors: Isabella Schmoelzer and Thomas C Wascher

    Citation: Cardiovascular Diabetology 2006 5:9

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  9. Content type: Original investigation

    Anemia and diabetes are risk factors for short-term mortality following an acute myocardial infarction(AMI). Anemia is more prevalent in patients with diabetes. We performed a retrospective study to assess the...

    Authors: David H Shu, Thomas PP Ransom, Colleen M O'Connell, Jafna L Cox, Stephanie M Kaiser, Shirl A Gee, Richard C Rowe, Ehud Ur and Syed Ali Imran

    Citation: Cardiovascular Diabetology 2006 5:8

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  10. Content type: Original investigation

    Diabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glu...

    Authors: Rajprasad Loganathan, Mehmet Bilgen, Baraa Al-Hafez, Mohammed D Alenezy and Irina V Smirnova

    Citation: Cardiovascular Diabetology 2006 5:7

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  11. Content type: Original investigation

    Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic r...

    Authors: Philipp Ehlermann, Kai Eggers, Angelika Bierhaus, Patrick Most, Dieter Weichenhan, Johannes Greten, Peter P Nawroth, Hugo A Katus and Andrew Remppis

    Citation: Cardiovascular Diabetology 2006 5:6

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  12. Content type: Original investigation

    Monocytes play an important role in innate immunity and atherosclerosis. A disturbed secretion of cytokines in lipopolysaccharide (LPS) activated monocytes from type 1 diabetes (T1D) patients has been describe...

    Authors: Gabriele Wehrwein, Markus Neumeier, Andreas Schäffler, Andrea Kopp, Johanna Weigert, Sabine Abke, Jürgen Schölmerich and Christa Buechler

    Citation: Cardiovascular Diabetology 2006 5:5

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  13. Content type: Review

    The endothelium is a thin monocelular layer that covers all the inner surface of the blood vessels, separating the circulating blood from the tissues. It is not an inactive organ, quite the opposite. It works ...

    Authors: Ricardo J Esper, Roberto A Nordaby, Jorge O Vilariño, Antonio Paragano, José L Cacharrón and Rogelio A Machado

    Citation: Cardiovascular Diabetology 2006 5:4

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  14. Content type: Original investigation

    Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly understood.

    Authors: Adam R Baker, Nancy F da Silva, David W Quinn, Alison L Harte, Domenico Pagano, Robert S Bonser, Sudhesh Kumar and Philip G McTernan

    Citation: Cardiovascular Diabetology 2006 5:1

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  15. Content type: Original investigation

    To determine the prevalence of, and patient characteristics associated with, antiplatelet therapy in a cohort of primary care patients with Type 1 or Type2 diabetes.

    Authors: Shaun R Miller, Benjamin Littenberg and Charles D MacLean

    Citation: Cardiovascular Diabetology 2005 4:18

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  16. Content type: Original investigation

    Individuals with diabetes are twice as likely to develop peripheral arterial disease (PAD), the manifestation of extensive atherosclerosis throughout the lower extremities. One putative determinant of PAD is t...

    Authors: Rebecca L Pollex, Mary Mamakeesick, Bernard Zinman, Stewart B Harris, Anthony JG Hanley and Robert A Hegele

    Citation: Cardiovascular Diabetology 2005 4:17

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  17. Content type: Original investigation

    Accelerated atherosclerosis is one of the major vascular complications of diabetes. Factors including hyperglycemia and hyperinsulinemia may contribute to accelerated vascular disease. Among the several mechan...

    Authors: Wenlan Duan, Latha Paka and Sivaram Pillarisetti

    Citation: Cardiovascular Diabetology 2005 4:16

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  18. Content type: Original investigation

    The aim of the present study was to evaluate, by heart rate variability (HRV) with 24-hours ECG Holter (HRV), the circadian autonomic activity in offspring of type 2 diabetic subjects and the relation with ins...

    Authors: A Fiorentini, A Perciaccante, A Paris, P Serra and L Tubani

    Citation: Cardiovascular Diabetology 2005 4:15

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  19. Content type: Review

    There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta. PPAR alpha activation increases high density lipoprotein (...

    Authors: Alexander Tenenbaum, Michael Motro and Enrique Z Fisman

    Citation: Cardiovascular Diabetology 2005 4:14

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  20. Content type: Original investigation

    The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study is examining the effects of long-term fibrate therapy on coronary heart disease (CHD) event rates in patients with diabetes mellitus. T...


    Citation: Cardiovascular Diabetology 2005 4:13

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  21. Content type: Original investigation

    Uncontrolled hyperglycemia is the main risk factor in the development of diabetic vascular complications. The endothelial cells are the first cells targeted by hyperglycemia. The mechanism of endothelial injur...

    Authors: Juying Han, Anil K Mandal and Linda M Hiebert

    Citation: Cardiovascular Diabetology 2005 4:12

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  22. Content type: Methodology

    The objective of this study was to determine the rate of blood pressure control according to 4 sets of Canadian guidelines published over a decade in patients with diabetes mellitus attending Diabetes Centres ...

    Authors: Cory Russell, Peggy Dunbar, Sonia Salisbury, Ingrid Sketris and George Kephart

    Citation: Cardiovascular Diabetology 2005 4:11

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  23. Content type: Original investigation

    Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.

    Authors: N Al-Daghri, R Chetty, PG McTernan, K Al-Rubean, O Al-Attas, AF Jones and S Kumar

    Citation: Cardiovascular Diabetology 2005 4:10

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  24. Content type: Review

    The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cro...

    Authors: Melvin R Hayden, James R Sowers and Suresh C Tyagi

    Citation: Cardiovascular Diabetology 2005 4:9

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  25. Content type: Editorial

    Drugs in the same class are generally thought to be therapeutically equivalent because of similar mechanisms of action (the so-called "class effect"). However, statins differ in multiple characteristics, inclu...

    Authors: Enrique Z Fisman, Yehuda Adler and Alexander Tenenbaum

    Citation: Cardiovascular Diabetology 2005 4:8

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  26. Content type: Original investigation

    The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with ...

    Authors: Christian Berne and Annica Siewert-Delle

    Citation: Cardiovascular Diabetology 2005 4:7

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  27. Content type: Original investigation

    Metabolic syndrome is a cluster of common cardiovascular risk factors that includes hypertension and insulin resistance. Hypertension and diabetes mellitus are frequent comorbidities and, like metabolic syndro...

    Authors: Cristiana Vitale, Giuseppe Mercuro, Carlotta Castiglioni, Alessandra Cornoldi, Arianna Tulli, Massimo Fini, Maurizio Volterrani and Giuseppe MC Rosano

    Citation: Cardiovascular Diabetology 2005 4:6

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  28. Content type: Review

    Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that...

    Authors: Jeanette Schultz Johansen, Alex K Harris, David J Rychly and Adviye Ergul

    Citation: Cardiovascular Diabetology 2005 4:5

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  29. Content type: Review

    Vascular calcification is associated with metabolic syndrome, diabetes, hypertension, atherosclerosis, chronic kidney disease, and end stage renal disease. Each of the above contributes to an accelerated and p...

    Authors: Melvin R Hayden, Suresh C Tyagi, Lisa Kolb, James R Sowers and Ramesh Khanna

    Citation: Cardiovascular Diabetology 2005 4:4

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  30. Content type: Original investigation

    In the present study we tested the hypothesis that progression of streptozotocin (STZ)-induced diabetes (14-days to 28-days) would produce renal and vascular dysfunction that correlate with altered p38- mitoge...

    Authors: Hongmei Chen, Sachin Brahmbhatt, Akanksha Gupta and Avadhesh C Sharma

    Citation: Cardiovascular Diabetology 2005 4:3

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  31. Content type: Original investigation

    In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated wheth...

    Authors: Rangnath Mishra and Michael S Simonson

    Citation: Cardiovascular Diabetology 2005 4:2

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  32. Content type: Case Report

    The importance of low high-density lipoprotein cholesterol (HDL-C), elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus), and an isolated low HDL-C is rapidly emerg...

    Authors: Melvin R Hayden and Suresh C Tyagi

    Citation: Cardiovascular Diabetology 2005 4:1

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  33. Content type: Original investigation

    Fibrates correct the typical lipid abnormalities of type 2 diabetes mellitus, yet no study, to date, has specifically set out to evaluate the role of fibrate therapy in preventing cardiovascular events in this...


    Citation: Cardiovascular Diabetology 2004 3:9

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  34. Content type: Original investigation

    Hypertriglyceridemia in combination with low HDL cholesterol levels is a risk factor for cardiovascular disease. Our objective was to evaluate the efficacy of ciprofibrate for the treatment of this form of dys...

    Authors: Carlos A Aguilar-Salinas, Andréia Assis-Luores-Vale, Benjamín Stockins, Hector Mario Rengifo, José Dondici Filho, Abrahão Afiune Neto, Lísia Marcílio Rabelo, Kerginaldo Paulo Torres, José Egídio Paulo de Oliveira, Carlos Alberto Machado, Eliana Reyes, Victor Saavedra, Fernando Florenzano, Ma Victoria Hernández, Sergio Hernandez Jiménez, Erika Ramírez…

    Citation: Cardiovascular Diabetology 2004 3:8

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  35. Content type: Original investigation

    Acute hyperglycaemia is an independent cardiovascular risk factor in Type 2 diabetes which may be mediated through increased oxidative damage to plasma low density lipoprotein, and in vitro, high glucose conce...

    Authors: Mike Sampson, Isabel Davies, Jelena Gavrilovic, Brendan Sussams, Jackie Brown, Sian Astley and David A Hughes

    Citation: Cardiovascular Diabetology 2004 3:7

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  36. Content type: Original investigation

    Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and prolife...

    Authors: Iris J Edwards, Janice D Wagner, Catherine A Vogl-Willis, Kenneth N Litwak and William T Cefalu

    Citation: Cardiovascular Diabetology 2004 3:6

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  37. Content type: Case Report

    Severe obesity is associated with important morbidity and increased mortality. The successes of lifestyle modifications and drug therapy have been partial and mostly unsustained in reducing obesity and its com...

    Authors: Philippe Woods, Carmen Paquette, Julie Martin, Jean-Gaston Dumesnil, Picard Marceau, Simon Marceau, Simon Biron, Frédéric Hould, Odette Lescelleur, Stéphane Lebel and Paul Poirier

    Citation: Cardiovascular Diabetology 2004 3:5

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  38. Content type: Original investigation

    Type 2 diabetes mellitus (DM-2) is one of the most prevalent chronic diseases of the aged and contributes to a significant amount of cardiovascular disease morbidity and mortality. Exercise training may be ben...

    Authors: Jonathan McGavock, Sandra Mandic, Richard Lewanczuk, Matthew Koller, Isabelle Vonder Muhll, Arthur Quinney, Dylan Taylor, Robert Welsh and Mark Haykowsky

    Citation: Cardiovascular Diabetology 2004 3:3

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  39. Content type: Original investigation

    Microalbuminuria and subsequent progression to proteinuria and nephropathy is associated with increased oxidative stress, increased inflammatory cytokines and increased cardiovascular (CVD) risk. The common fu...

    Authors: Jeffrey W Stephens, Steven J Hurel, Jayshree Acharya and Steve E Humphries

    Citation: Cardiovascular Diabetology 2004 3:2

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  40. Content type: Review

    Vascularization is an exciting and complex mechanism involving angiogenesis and arteriogenesis. The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are associated with multiple metabolic toxicities...

    Authors: Melvin R Hayden and Suresh C Tyagi

    Citation: Cardiovascular Diabetology 2004 3:1

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  41. Content type: Original investigation

    Impaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes, associated with components of the metabolic syndrome. There are no data concerning fibrinolysis in subjects with normal glucose...

    Authors: Mats CE Eliasson, Jan-Håkan Jansson, Bernt Lindahl and Birgitta Stegmayr

    Citation: Cardiovascular Diabetology 2003 2:19

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  42. Content type: Original investigation

    Angiogenic therapy with vascular endothelial growth factor (VEGF) has been proposed as a treatment paradigm for patients suffering from an insufficiency of collateral vessels. Diabetes is associated with incre...

    Authors: Ariel Roguin, Samy Nitecki, Irit Rubinstein, Eviatar Nevo, Aaron Avivi, Nina S Levy, Zaid A Abassi, Edmond Sabo, Orit Lache, Meira Frank, Aaron Hoffman and Andrew P Levy

    Citation: Cardiovascular Diabetology 2003 2:18

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  43. Content type: Original investigation

    Diabetic dyslipoproteinemia is characterized by hypertriglyceridemia, low HDL-cholesterol and often elevated LDL-cholesterol and is a strong risk factor for atherosclerosis. Adhesion molecule levels are elevat...

    Authors: Klaus Empen, Robert JA Frost, H Christian Geiss, Carsten Otto and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2003 2:17

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  44. Content type: Original investigation

    Patients with diabetic cardiomyopathy have an impaired myocardial glucose handling and distal distribution of coronary atherosclerosis. Trimetazidine, an anti-ischemic metabolic agent, improves myocardial gluc...

    Authors: Giuseppe MC Rosano, Cristiana Vitale, Barbara Sposato, Giuseppe Mercuro and Massimo Fini

    Citation: Cardiovascular Diabetology 2003 2:16

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  45. Content type: Original investigation

    An insertion/deletion polymorphism in the α2B-adrenoceptor (AR) has been associated with the risk for acute myocardial infarction (AMI) and sudden cardiac death. In this study we tested whether this polymorphism ...

    Authors: Amir Snapir, Mika Scheinin, Leif C Groop and Marju Orho-Melander

    Citation: Cardiovascular Diabetology 2003 2:15

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