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  1. Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program.

    Authors: David J Leehey, Irfan Moinuddin, Joseph P Bast, Shahzad Qureshi, Christine S Jelinek, Cheryl Cooper, Lonnie C Edwards, Bridget M Smith and Eileen G Collins

    Citation: Cardiovascular Diabetology 2009 8:62

    Content type: Original investigation

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  2. Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic...

    Authors: Haruhiko Osawa, Yasufumi Doi, Hideichi Makino, Toshiharu Ninomiya, Koji Yonemoto, Ryoichi Kawamura, Jun Hata, Yumihiro Tanizaki, Mitsuo Iida and Yutaka Kiyohara

    Citation: Cardiovascular Diabetology 2009 8:60

    Content type: Original investigation

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  3. A large number of people throughout the world have diabetes and the prevalence is increasing. Persons with diabetes have a twice higher risk of cardiovascular disease than those without diabetes. There is a la...

    Authors: Marina Taloyan, Alexandre Wajngot, Sven-Erik Johansson, Jonas Tovi and Jan Sundquist

    Citation: Cardiovascular Diabetology 2009 8:59

    Content type: Original investigation

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  4. Diabetes mellitus (DM) has reached epidemic proportions and is an important risk factor for heart failure (HF). Left ventricular diastolic dysfunction (LVDD) is recognized as the earliest manifestation of DM-i...

    Authors: Wilfried Dinh, Reiner Füth, Werner Nickl, Thomas Krahn, Peter Ellinghaus, Thomas Scheffold, Lars Bansemir, Alexander Bufe, Michael Coll Barroso and Mark Lankisch

    Citation: Cardiovascular Diabetology 2009 8:58

    Content type: Original investigation

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  5. The risk-benefit ratio of aspirin therapy in prevention of cardiovascular disease (CVD) remains contentious, especially in type 2 diabetes. This study examined the benefit and harm of low-dose aspirin (daily d...

    Authors: Wilson Y Leung, Wing-yee So, Derek Stewart, Augustine Lui, Peter C Tong, Gary T Ko, Alice P Kong, Ronald C Ma, Francis K Chan, Xilin Yang, Sau-chu Chiang and Juliana C Chan

    Citation: Cardiovascular Diabetology 2009 8:57

    Content type: Original investigation

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  6. The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tol...

    Authors: Saher Hamed, Benjamin Brenner, Anat Aharon, Deeb Daoud and Ariel Roguin

    Citation: Cardiovascular Diabetology 2009 8:56

    Content type: Original investigation

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  7. Increased resting heart rate (RHR) may be associated with increased cardiovascular morbidity. Our aim was to explore the possibility that increased RHR is associated with the prevalence of the metabolic syndro...

    Authors: Ori Rogowski, Arie Steinvil, Shlomo Berliner, Michael Cohen, Nili Saar, Orit Kliuk Ben-Bassat and Itzhak Shapira

    Citation: Cardiovascular Diabetology 2009 8:55

    Content type: Original investigation

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  8. Cardiovascular disease is the main cause of premature death in patients with type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack or stroke. Accurate knowledge of the c...

    Authors: Ville-Petteri Mäkinen, Carol Forsblom, Lena M Thorn, Johan Wadén, Kimmo Kaski, Mika Ala-Korpela and Per-Henrik Groop

    Citation: Cardiovascular Diabetology 2009 8:54

    Content type: Original investigation

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  9. Patients with type 2 diabetes are at increased risk of cardiovascular events, and there is an associated economic burden attached to this risk. We conducted a retrospective claims database analysis to evaluate...

    Authors: Robert J Straka, Larry Z Liu, Prafulla S Girase, Allyson DeLorenzo and Richard H Chapman

    Citation: Cardiovascular Diabetology 2009 8:53

    Content type: Original investigation

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  10. Metabolic syndrome increases cardiovascular risk. Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study includ...

    Authors: Jorge Escobedo, Herman Schargrodsky, Beatriz Champagne, Honorio Silva, Carlos P Boissonnet, Raul Vinueza, Marta Torres, Rafael Hernandez and Elinor Wilson

    Citation: Cardiovascular Diabetology 2009 8:52

    Content type: Original investigation

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  11. The GOOD (Global Cardiometabolic Risk Profile in Patients with Hypertension Disease) survey showed that blood pressure control was significantly worse in hypertensive patients with metabolic syndrome and/or di...

    Authors: Walter Zidek, Lisa Naditch-Brûlé, Stefano Perlini, Csaba Farsang and Sverre E Kjeldsen

    Citation: Cardiovascular Diabetology 2009 8:51

    Content type: Original investigation

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  12. Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified les...

    Authors: Michael Lehrke, Martin Greif, Uli C Broedl, Corinna Lebherz, Rüdiger P Laubender, Alexander Becker, Franz von Ziegler, Janine Tittus, Maximilian Reiser, Christoph Becker, Burkhard Göke, Gerhard Steinbeck, Alexander W Leber and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2009 8:50

    Content type: Original investigation

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  13. Type 2 diabetes mellitus (T2DM) is commonly associated with both microvascular and macrovascular complications and a strong correlation exists between glycaemic control and the incidence and progression of vas...

    Authors: Federico Biscetti, Giuseppe Straface, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Paola Rizzo, Giulia De Angelis, Luigi Iuliano, Giovanni Ghirlanda and Andrea Flex

    Citation: Cardiovascular Diabetology 2009 8:49

    Content type: Original investigation

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  14. Thrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease (CAD). We hypothesize, that hemostatic and rheological risk factors may be of m...

    Authors: Thomas W Jax, Ansgar J Peters, Gunnar Plehn and Frank-Chris Schoebel

    Citation: Cardiovascular Diabetology 2009 8:48

    Content type: Original investigation

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  15. Endothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functional capacity is impaired. Re...

    Authors: Olivia van Oostrom, Dominique PV de Kleijn, Joost O Fledderus, Mario Pescatori, Andrew Stubbs, Attie Tuinenburg, Sai Kiang Lim and Marianne C Verhaar

    Citation: Cardiovascular Diabetology 2009 8:47

    Content type: Original investigation

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  16. Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and ather...

    Authors: Juying Han, Fuming Zhang, Jin Xie, Robert J Linhardt and Linda M Hiebert

    Citation: Cardiovascular Diabetology 2009 8:46

    Content type: Original investigation

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  17. Nε-Carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertensi....

    Authors: Marcus Baumann, Tom Richart, Daniel Sollinger, Jaroslav Pelisek, Marcel Roos, Tatiana Kouznetsova, Hans-Henning Eckstein, Uwe Heemann and Jan A Staessen

    Citation: Cardiovascular Diabetology 2009 8:45

    Content type: Original investigation

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  18. All previous studies that investigated the association between abdominal fat distribution and insulin resistance evaluated subcutaneous and visceral fat area and/or volume, but these values were not related to...

    Authors: Yoshinori Miyazaki and Ralph A DeFronzo

    Citation: Cardiovascular Diabetology 2009 8:44

    Content type: Original investigation

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  19. Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated wi...

    Authors: Benjamin E Reinking, Elesa W Wedemeyer, Robert M Weiss, Jeffrey L Segar and Thomas D Scholz

    Citation: Cardiovascular Diabetology 2009 8:43

    Content type: Original investigation

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  20. White adipose tissue (WAT) is a disperse organ acting as energy storage depot and endocrine/paracrine controlling factor in the management of energy availability and inflammation. WAT sites response under ener...

    Authors: María del Mar Romero, José Antonio Fernández-López, Montserrat Esteve and Marià Alemany

    Citation: Cardiovascular Diabetology 2009 8:42

    Content type: Original investigation

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  21. The prevalence of diabetes is increasing rapidly, and individuals with diabetes are at high risk for cardiovascular disorders. Subsequently the percentage of patients with diabetes subjected to revascularisati...

    Authors: Chris PH Lexis, Braim M Rahel, Joan G Meeder, Felix Zijlstra and Iwan CC van der Horst

    Citation: Cardiovascular Diabetology 2009 8:41

    Content type: Review

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  22. A meta-analysis suggested the use of rosiglitazone was associated with an increased risk for cardiovascular (CV) events. Rosiglitazone remained available for use as more definitive safety trials were ongoing. ...

    Authors: Doreen M Rabi, Adriane M Lewin, Garielle E Brown, Alun L Edwards, Jeffrey A Johnson and William A Ghali

    Citation: Cardiovascular Diabetology 2009 8:40

    Content type: Review

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  23. In vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose of the present study was to study in a rat model ...

    Authors: Charissa E van den Brom, Marc C Huisman, Ronald Vlasblom, Nicky M Boontje, Suzanne Duijst, Mark Lubberink, Carla FM Molthoff, Adriaan A Lammertsma, Jolanda van der Velden, Christa Boer, D Margriet Ouwens and Michaela Diamant

    Citation: Cardiovascular Diabetology 2009 8:39

    Content type: Original investigation

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  24. Bariatric surgery is able to improve glucose and lipid metabolism, and cardiovascular function in morbid obesity. Aim of this study was to compare the long-term effects of malabsorptive (biliary pancreatic div...

    Authors: Antonio E Pontiroli, Marco Laneri, Annamaria Veronelli, Francesca Frigè, Giancarlo Micheletto, Franco Folli, Gianfranco Adami and Nicola Scopinaro

    Citation: Cardiovascular Diabetology 2009 8:37

    Content type: Original investigation

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  25. We investigated whether macronutrient composition of energy-restricted diets influences the efficacy of a telemedically guided weight loss program.

    Authors: Sabine Frisch, Armin Zittermann, Heiner K Berthold, Christian Götting, Joachim Kuhn, Knut Kleesiek, Peter Stehle and Heinrich Körtke

    Citation: Cardiovascular Diabetology 2009 8:36

    Content type: Original investigation

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  26. Our aim was to compare the effects of a Paleolithic ('Old Stone Age') diet and a diabetes diet as generally recommended on risk factors for cardiovascular disease in patients with type 2 diabetes not treated w...

    Authors: Tommy Jönsson, Yvonne Granfeldt, Bo Ahrén, Ulla-Carin Branell, Gunvor Pålsson, Anita Hansson, Margareta Söderström and Staffan Lindeberg

    Citation: Cardiovascular Diabetology 2009 8:35

    Content type: Original investigation

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  27. Few studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF) in populations of low or middle income countries. The systematic collection of a broad set of both traditional and...

    Authors: Pascal Bovet, Sarah Romain, Conrad Shamlaye, Shanti Mendis, Roger Darioli, Walter Riesen, Luc Tappy and Fred Paccaud

    Citation: Cardiovascular Diabetology 2009 8:34

    Content type: Original investigation

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  28. Both obesity and type 2 diabetes are among the risk factors for breast cancer development. Combined effect of these metabolic abnormalities on breast cancer risk however, has not been examined in premenopausal...

    Authors: Majed S Alokail, Nasser M Al-Daghri, Omar S Al-Attas and Tajamul Hussain

    Citation: Cardiovascular Diabetology 2009 8:33

    Content type: Original investigation

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  29. In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an...

    Authors: Paola Failli, Chiara Alfarano, Sergio Franchi-Micheli, Edoardo Mannucci, Elisabetta Cerbai, Alessandro Mugelli and Laura Raimondi

    Citation: Cardiovascular Diabetology 2009 8:32

    Content type: Original investigation

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  30. A variant in the promoter of the human uncoupling protein 2 (UCP2) gene, the G-866A polymorphism, has been associated with future risk of coronary heart disease events, in those devoid of traditional risk fact...

    Authors: Barry R Palmer, Courtney L Devereaux, Sukhbir S Dhamrait, Tessa J Mocatta, Anna P Pilbrow, Chris M Frampton, Lorraine Skelton, Tim G Yandle, Christine C Winterbourn, A Mark Richards, Hugh E Montgomery and Vicky A Cameron

    Citation: Cardiovascular Diabetology 2009 8:31

    Content type: Original investigation

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  31. The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort.

    Authors: Rimei Nishimura, Hironari Sano, Toru Matsudaira, Aya Morimoto, Yumi Miyashita, Takako Shirasawa, Akatsuki Kokaze and Naoko Tajima

    Citation: Cardiovascular Diabetology 2009 8:30

    Content type: Original investigation

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  32. We have recently demonstrated in man that a functional allelic polymorphism in the Haptoglobin (Hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (MI)...

    Authors: Roy Asaf, Shany Blum, Ariel Roguin, Shiri Kalet-Litman, Jad Kheir, Avi Frisch, Rachel Miller-Lotan and Andrew P Levy

    Citation: Cardiovascular Diabetology 2009 8:29

    Content type: Original investigation

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  33. Type 2 diabetes mellitus (T2DM) is a genetically heterogeneous disease, hepatocyte nuclear factor-1 homeobox A (HNF1A) single-nucleotide polymorphisms (SNPs) playing a minor role in its pathogenesis. HNF1A is a f...

    Authors: Fernando MA Giuffrida, Gilberto K Furuzawa, Teresa S Kasamatsu, Marcos M Oliveira, Andre F Reis and Sergio A Dib

    Citation: Cardiovascular Diabetology 2009 8:28

    Content type: Original investigation

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  34. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of endothelial nitric oxide synthase (eNOS) that is associated with endothelial dysfunction, and is a risk marker for cardiovascular disease, a sig...

    Authors: Latika Sibal, Sharad C Agarwal, Edzard Schwedhelm, Nicole Lüneburg, Rainer H Böger and Philip D Home

    Citation: Cardiovascular Diabetology 2009 8:27

    Content type: Original investigation

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  35. The benefit of statins for prevention of cardiovascular events in type 2 diabetes is established, but a gap exists between guideline recommendations and clinical practice. The aim of the study was to identify ...

    Authors: Heiner K Berthold, Ioanna Gouni-Berthold, Michael Böhm, Wilhelm Krone and Kurt P Bestehorn

    Citation: Cardiovascular Diabetology 2009 8:25

    Content type: Original investigation

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  36. Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted ...

    Authors: Alberto O Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C Lopez-Alvarenga, M Michelle Leland, M Elizabeth Tejero, GianPio Sorice, Francesca Casiraghi, Alberto Davalli, Raúl A Bastarrachea, Anthony G Comuzzie, Ralph A DeFronzo and Franco Folli

    Citation: Cardiovascular Diabetology 2009 8:22

    Content type: Original investigation

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  37. Over the last 30 years the citizens of the United Arab Emirates have experienced major changes in life-style secondary to increased affluence. Currently, 1 in 5 adults have diabetes mellitus, but the associati...

    Authors: Latifa M Baynouna, Anthony D Revel, Nico JD Nagelkerke, Tariq M Jaber, Aziza O Omar, Nader M Ahmed, Mohammad K Nazirudeen, Mamdouh F Al Sayed, Fuad A Nour and Sameh Abdouni

    Citation: Cardiovascular Diabetology 2009 8:21

    Content type: Original investigation

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  38. Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the dev...

    Authors: Omar S Al-Attas, Nasser M Al-Daghri, Khalid Al-Rubeaan, Nancy F da Silva, Shaun L Sabico, Sudhesh Kumar, Philip G McTernan and Alison L Harte

    Citation: Cardiovascular Diabetology 2009 8:20

    Content type: Original investigation

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  39. Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitiv...

    Authors: Svetlana Kalinchenko, Alexandr Zemlyanoy and Louis J Gooren

    Citation: Cardiovascular Diabetology 2009 8:19

    Content type: Case Report

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  40. Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventri...

    Authors: Fabien Forcheron, Alexandra Basset, Pauline Abdallah, Peggy Del Carmine, Nicolas Gadot and Michel Beylot

    Citation: Cardiovascular Diabetology 2009 8:16

    Content type: Original investigation

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  41. Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid reten...

    Authors: Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo and Leif Groop

    Citation: Cardiovascular Diabetology 2009 8:15

    Content type: Original investigation

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  42. Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies ...

    Authors: Joey C Eisenmann, Mark A Sarzynski, Kim Glenn, Max Rothschild and Kate A Heelan

    Citation: Cardiovascular Diabetology 2009 8:14

    Content type: Original investigation

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  43. Obesity is a major risk factor for development and progression of hypertension and diabetes, which often coexist in obese patients. Losing weight by means of energy restriction and physical activity has been e...

    Authors: Guixiang Zhao, Earl S Ford, Chaoyang Li and Ali H Mokdad

    Citation: Cardiovascular Diabetology 2009 8:13

    Content type: Original investigation

    Published on:

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