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Table 3 Baseline and follow-up CCTA findings in evolocumab group and control group: patient based analysis

From: Evolocumab attenuate pericoronary adipose tissue density via reduction of lipoprotein(a) in type 2 diabetes mellitus: a serial follow-up CCTA study

 

Evolocumab (n = 85)

Control (n = 85)

p value between groups

Baseline

Follow-up

p

Baseline

Follow-up

p

Baseline

Follow-up

Total Agatston scorea

178.2 (96.5, 344.6)

251.5 (157.6, 384.0)

0.057

214 (83.0, 421)

228.1 (118.5, 424.2)

0.536

0.900

0.333

Obstructive CAD, n (%)

44 (51.8)

30 (35.2)

0.044

42 (49.4)

39 (45.9)

0.758

0.878

0.211

High-risk plaque features, n (%)

        

 Low attenuation plaque

33 (38.8)

19 (22.3)

0.031

37 (43.5)

34 (40.0)

0.755

0.640

0.020

 Positive remodeling

45 (52.9)

31 (36.4)

0.044

47 (55.2)

42 (49.4)

0.622

0.877

0.121

 Spotty calcification

15 (17.6)

13 (15.3)

0.836

16 (18.8)

14 (16.4)

0.840

1.000

1.000

 Napkin-ring sign

26 (30.1)

16 (18.8)

0.109

29 (34.1)

22 (25.9)

0.315

0.743

0.357

Atheroma volume (mm3)a

        

 Total plaque volume

223.4 (154.2, 573.7)

289.2 (195.8, 582.3)

0.194

218.4 (119. 3, 457.5)

238.6 (172.7, 457.5)

0.420

0.576

0.191

 Calcified plaque volume

129.3 (59.5, 238.3)

188.3 (115.7, 361.0)

0.015

103.5 (37.8, 233.5)

126.0 (62.0, 214.5)

0.097

0.281

0.030

 Noncalcified plaque volume

125.0 (65.3, 269.7)

107.5 (40.6, 180.6)

0.038

147.2 (70.3, 273.2)

117.2 (55.0, 194.5)

0.475

0.715

0.043

 Necrotic volume

0 (0, 13.4)

0 (0, 4.7)

 < 0.001

0 (0, 26.2)

0 (0, 21.1)

0.713

0.611

0.047

PCATRCA (HU)a

− 79.0 (− 83.5, − 74.0)

− 85.0 (− 89.0, − 82.0)

 < 0.001

− 79.0 (− 86.5, − 72.5)

− 81.0 (− 90.0, − 76.5)

0.102

0.772

0.015

PCATLMT (HU)a

− 76.3 (− 80.6, − 71.3)

− 82.3 (− 86.3, − 79.2)

 < 0.001

− 75.4 (− 82.5, − 70.1)

− 78.7 (− 86.0, − 71.0)

0.172

0.980

0.001

PCATLAD (HU)a

76.9 (− 81.1, − 71.9)

− 83.1 (− 87.2, − 80.1)

 < 0.001

76.3 (− 84.2, − 70.6)

79.1 (− 87.4, − 72.5)

0.076

0.773

0.013

  1. Unless otherwise specified, data are numbers of patients, with percentages in parentheses
  2. CAD, Coronary artery disease; HU, Hounsfield unit; LAD, left anterior descending artery; LMT, left main trunk; PCAT, Pericoronary adipose tissue; RCA, right coronary artery
  3. aNumbers are medians, with interquartile ranges in parentheses
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Cardiovascular Diabetology

ISSN: 1475-2840