Fig. 2
A representative case of a type 2 diabetes patients treated with evolocumab for 48-week. A–C The baseline LDL-C and Lp(a) level was 3.6 mmol/L and 64 mg/dL. Baseline CCTA revealed noncalcified plaque with moderate stenosis of middle left anterior descending artery. The total plaque volume was 132.2 mm3 and the PCAT density of right coronary artery was − 79HU. D–F After 48-week treatment, both the LDL-C and Lp(a) level were reduced to 1.5 mmol/L and 19 mg/dL, respectively. The follow-up CCTA revealed the lesion regression with mild stenosis. The follow-up total plaque volume decreased to 11.8 mm3 and PCAT density of right coronary artery attenuated to − 85HU. CCTA, coronary computed tomography angiography; HU, hounsfield unit; Lp(a), lipoprotein(a); LDL-C, low-density lipoprotein cholesterol; PCAT, pericoronary adipose tissue