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Table 3 The risk of MACE occurrence by multivariable analysis

From: Effects of metabolic parameters’ variability on cardiovascular outcomes in diabetic patients

 

Univariable

Final multivariable model

HR (95% CI)

p-value

HR (95% CI)

p-value

Age

1.02 (1.01–1.03)

< 0.01

1.01 (1.01–1.02)

< 0.01

Male sex

1.74 (1.52-2.00)

< 0.01

1.35 (1.17–1.56)

< 0.01

Smoking

1.65 (1.01–1.03)

< 0.01

  

Creatinine

1.17 (1.15–1.20)

< 0.01

1.10 (1.07–1.14)

< 0.01

Hypertension

2.67 (2.13–3.33)

< 0.01

  

Dyslipidemia

1.96 (1.47–2.61)

< 0.01

  

Prior MI

23.65 (20.76–26.93)

< 0.01

19.57 (17.09–22.40)

< 0.01

Prior stroke

1.50 (1.28–1.76)

< 0.01

  

Risk score (high risk)

1.91 (1.60–2.27)

< 0.01

  

Risk score (very high risk)

2.86 (2.41–3.39)

< 0.01

  

Baseline SBP

1.01 (1.00-1.01)

0.024

  

Baseline TC

1.00 (0.99-1.00)

0.875

1.45 (1.25–1.68)

< 0.01

Baseline TG

1.00 (1.00–1.00)

< 0.01

  

Baseline glucose

1.00 (1.00–1.00)

< 0.01

  

High SBP-CV

2.43 (2.11–2.79)

< 0.01

1.79 (1.54–2.07)

< 0.01

High TC-CV

1.83 (1.50–2.06)

< 0.01

1.54 (1.34–1.77)

< 0.01

High TG-CV

1.23 (0.85–1.97)

< 0.01

1.15 (1.01–1.31)

0.040

High glucose-CV

2.13 (1.55–2.27)

< 0.01

1.61 (1.40–1.86)

< 0.01

High mean SBP

0.99 (0.88–1.13)

0.935

  

High mean TC

0.55 (0.48–0.63)

< 0.01

0.62 (0.53–0.73)

< 0.01

High mean TG

1.19 (1.05–1.35)

< 0.01

  

High mean glucose

1.33 (1.17–1.52)

< 0.01

  

Anti-hypertensive drug

3.79 (2.97–4.82)

< 0.01

1.74 (1.35–2.24)

< 0.01

Statin

1.72 (1.43–2.08)

< 0.01

  

Insulin

1.60 (1.41–1.82)

< 0.01

  
  1. Multivariable analyses by Cox regression
  2. CI, confidence interval; CV, coefficient of variability; HR, hazard ratio; MACE, major adverse cardiovascular events; MI, myocardial infarction; SBP, systolic blood pressure; TC, total cholesterol; TG, triglycerides