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Table 5 Cox regression analysis for MACE of CMD patients

From: Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome

 

Univariate analysis

HR (95% CI)

P value

Multivariate analysis

HR (95% CI)

P value

Age

1.024 (0.996–1.052)

0.090

1.027 (0.996–1.059)

0.085

Male

1.221 (0.737–2.025)

0.438

  

BMI

0.999 (0.925–1.079)

0.981

  

Heart rate

1.003 (0.982–1.025)

0.768

  

Atrial fibrillation

2.443 (0.975–6.116)

0.057

1.256 (0.469–3.362)

0.650

Smoking

1.128 (0.621–2.049)

0.693

  

Hypertension

1.367 (0.809–2.311)

0.243

  

PCI performed

1.181 (0.719–1.938)

0.512

  

Diabetes

1.828 (1.115–2.999)

0.017

1.287 (0.761–2.176)

0.346

CKD

1.926 (0.947–3.916)

0.070

0.873 (0.288–2.645)

0.810

CAD

1.369 (0.825–2.270)

0.224

  

1- vessel disease

0.995 (0.557–1.778)

0.987

  

2- vessel disease

1.174 (0.647–2.128)

0.597

  

3- vessel disease

1.654 (0.816–3.353)

0.163

  

TyG index

1.506 (1.085–2.090)

0.014

-

 

TyG Tertiles

    

T1

Reference

 

Reference

 

T2

1.357 (0.689–2.674)

0.377

1.595 (0.785–3.241)

0.197

T3

2.157 (1.156–4.025)

0.016

2.132 (1.066–4.261)

0.032

TG

1.100 (0.960–1.261)

0.171

  

FBG

1.141 (1.047–1.244)

0.003

-

 

HbA1c

1.161 (0.946–1.425)

0.153

  

CRP

0.990 (0.952–1.031)

0.633

  

Serum creatinine

1.012 (1.001–1.024)

0.033

1.010 (0.991–1.028)

0.307

TC

1.054 (0.837–1.329)

0.654

  

LDL-C

1.039 (0.794–1.359)

0.783

  

LVEF

0.914 (0.884–0.944)

 < 0.001

0.925 (0.890–0.961)

 < 0.001

caFFR

0.011 (1 × 10–6-85.756)

0.324

  

caIMR

0.998 (0.975–1.021)

0.856

  

Aspirin

0.695 (0.416–1.162)

0.166

  

Clopidogrel

1.606 (0.968–2.665)

0.067

1.341 (0.786–2.287)

0.282

Statin

1.243 (0.566–2.729)

0.588

  

ACEI/ARB

1.521 (0.926–2.497)

0.097

0.997 (0.562–1.771)

0.993

Beta blocker

0.804 (0.488–1.325)

0.392

  

CCB

1.048 (0.633–1.735)

0.855

  
  1. MACE major adverse cardiovascular event, BMI body mass index, PCI percutaneous coronary intervention, CKD chronic kidney disease, CAD coronary artery disease, TyG index triglyceride-glucose index, TG triglyceride, FBG fasting blood glucose, HbA1c hemoglobin A1c, CRP C-reactive protein, TC total cholesterol, LDL-C low-density lipoprotein-cholesterol, LVEF left ventricular ejection fraction, caFFR coronary angiography-derived fractional flow reserve, caIMR coronary angiography-derived index of microcirculatory resistance, ACEI/ARB angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker, CCB calcium channel blocker, HR hazard ratio, CI confidence interval