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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Diabetes is accompanied by secretion of pro-atherosclerotic exosomes from vascular smooth muscle cells

Fig. 6

Exposure of HCAECs to DVEs promotes increased surface expression of ICAM-1 and RhoA activity in a miR-221/222 dependent manner. A Expression of mRNA encoding ICAM-1 in HCAECS treated with exosomes from VSMCs of non-diabetic (NVE) and diabetic (DVE) origin treated with non-targeting siRNA or miR-221/222 targeting siRNA (+KD). B RhoA activity in HCAECS treated with exosomes from VSMCs of non-diabetic (NVE) and diabetic (DVE) origin treated with non-targeting siRNA or miR-221/222 targeting siRNA (+KD). Data is expressed as the mean ± SEM. *p < 0.05

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Cardiovascular Diabetology

ISSN: 1475-2840