Table 2 Univariate and multivariate association of weight changes with major CV outcomes in CANVAS. Entries are Hazard Ratio [95% confidence interval]

Univariate

Gainers vs Stable

1.85 [1.22–2.72]

1.84 [1.38–2.40]

1.26 [0.99–1.59]

1.25 [0.86–1.76]

Losers vs Stable

2.06 [1.40–2.95]

1.67 [1.26–2.18]

1.23 [0.97–1.54]

1.33 [0.93–1.83]

Cana vs placebo

0.60 [0.45–0.79]

0.76 [0.63–0.93]

0.91 [0.78–1.06]

0.86 [0.69–1.08]

Multivariate

Gainers vs Stable

1.43 [0.93–2.13]

1.61 [1.20–2.13]

1.17 [0.91–1.47]

1.14 [0.78–1.62]

Losers vs Stable

1.67 [1.11–2.46]

1.53 [1.14–2.03]

1.18 [0.92–1.49]

1.27 [0.88–1.78]

Cana vs placebo

0.60 [0.45–0.80]

0.78 [0.64–0.96]

0.92 [0.78–1.07]

0.85 [0.68–1.08]

Sex (male)

1.09 [0.79–1.55]

1.02 [0.82–1.29]

1.27 [1.07–1.52]

1.63 [1.24–2.17]

Age (SD)

1.72 [1.47–2.03]

1.54 [1.38–1.72]

1.26 [1.17–1.37]

1.13 [1.00–1.28]

Baseline weight (SD)

1.45 [1.25–1.68]

1.21 [1.09–1.35]

1.09 [1.01–1.19]

1.09 [0.97–1.23]

Ln[UACR (mg/g)]

1.37 [1.27–1.48]

1.37 [1.29–1.44]

1.16 [1.11–1.22]

1.01 [0.94–1.09]

Smoking

1.03 [0.66–1.56]

1.19 [0.89–1.55]

1.01 [0.82–1.24]

0.86 [0.62–1.18]

Use of diuretics

2.25 [1.63–3.13]

1.72 [1.40–2.13]

1.05 [0.90–1.23]

1.03 [0.82–1.30]

Use of statins

1.04 [0.73–1.54]

0.81 [0.64–1.02]

0.75 [0.63–0.89]

0.93 [0.71–1.24]

Use of antithrombotics

2.49 [1.59–4.12]

2.10 [1.58–2.83]

1.65 [1.35–2.01]

1.77 [1.30–2.46]

Use of insulin

1.12 [0.80–1.58]

1.17 [0.93–1.48]

1.21 [1.02–1.44]

1.26 [0.98–1.64]

Use of metformin

0.68 [0.50–0.92]

0.69 [0.56–0.85]

0.74 [0.63–0.87]

0.84 [0.66–1.09]

Use of sulphonylureas

1.18 [0.85–1.63]

1.23 [0.98–1.53]

0.93 [0.78–1.10]

0.85 [0.66–1.10]

Use of GLP-1 RA

1.60 [0.86–2.74]

1.40 [0.83–2.19]

1.07 [0.69–1.58]

0.93 [0.50–1.72]