Predictive value of high sensitivity C-reactive protein in three-vessel disease patients with and without type 2 diabetes

Table 4 Evaluation of predictive models for endpoints using the C-index, NRI and IDI

Patients with diabetes	C-index (95% CI)	P	NRI (95% CI)	P	IDI (95% CI)	P
All-cause death
Traditional risk factors	0.68 (0.60–0.77)	Reference	Reference	–	Reference	–
Traditional risk factors + hs-CRP	0.70 (0.61–0.79)	0.510	0.1314 (−0.1648–0.4276)	0.384	6e-04 (−0.0011–0.0022)	0.504
MACCE
Traditional risk factors	0.53 (0.50–0.57)	Reference	Reference	–	Reference	–
Traditional risk factors + hs-CRP	0.59 (0.56–0.63)	0.008	0.2074 (0.0804–0.3344)	0.001	0.0086 (0.003–0.0142)	0.003

Patients without diabetes	C-index (95% CI)	P	NRI (95% CI)	P	IDI (95% CI)	P
All-cause death
Traditional risk factors	0.74 (0.64–0.84)	Reference	Reference	–	Reference	–
Traditional risk factors + hs-CRP	0.76 (0.65–0.86)	0.287	0.0883 (−0.2087–0.3853)	0.560	0.0054 (−0.0026–0.0133)	0.185
MACCE
Traditional risk factors	0.52 (0.49–0.55)	Reference	Reference	–	Reference	–
Traditional risk factors + hs-CRP	0.56 (0.53–0.59)	0.018	0.0988 (−0.0052–0.2027)	0.062	0.0031 (2e-04–0.006)	0.036

Traditional risk factors included age, gender, smoking, hypertension, hyperlipidemia and chronic kidney disease
C-index concordance index, CI confidence interval, HR hazard ratio, Hs-CRP high-sensitivity C-reactive protein, IDI integrated discrimination improvement, NRI net reclassification improvement, MACCE major adverse cardiac and cerebrovascular events

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