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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: L-Arginine in diabetes: clinical and preclinical evidence

Fig. 1

L-Arg once in the cell can be metabolized by Arginase. The products of this enzyme are: L-Ornithine, which is further cleaved to polyamines by ornithine decarboxylase (ODC), L-proline by ornithine aminotransferase (OAT), and urea. These compounds exert negative effects on glucose metabolism. When L-Arg is cleaved in nitric oxide (NO) and L-citrulline by the nitric oxide synthase (NOS), these compounds have positive effects on glucose metabolism, also exerting beneficial action on the cardiovascular system

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