Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension

Table 3 Association of TyG, sICAS, and ICASB with ischemic stroke recurrence

Variable	No. total	No. event (%)	Unadjusted HR (95% CI)	P value	Model I HR (95% CI)	P value	Model II HR (95% CI)	P value	Model III HR (95% CI)	P value
TyG (continuous)	1281	117 (9.1)	1.15 (0.9–1.47)	0.254	1.12 (0.86–1.46)	0.388	1.04 (0.78–1.38)	0.812	1.13 (0.85–1.49)	0.403
TyG (categories)
TyG quartile 1	320	19 (5.9)	1 (Ref.)		1 (Ref.)		1 (Ref.)		1 (Ref.)
TyG quartile 2	320	32 (10)	1.73 (0.98–3.05)	0.059	1.85 (1.02–3.36)	0.043	1.82 (0.97–3.41)	0.061	1.72 (0.91–3.26)	0.065
TyG quartile 3	320	32 (10)	1.72 (0.98–3.04)	0.061	1.85 (1.01–3.38)	0.046	1.88 (1.01–3.53)	0.048	1.96 (1.05–3.66)	0.043 0.010
TyG quartile 4	321	34 (10.6)	1.84 (1.05–3.23)	0.033	1.9 (1.04–3.48)	0.038	1.91 (1.12–3.15)	0.027	2.02 (1.07–3.84)	0.025
ICASB (continuous)	1281	117 (9.1)	1.07 (1.03–1.12)	0.001	1.08 (1.04–1.13)	< 0.001	1.08 (1.03–1.13)	0.003	1.08 (1.03–1.13)	0.002
ICASB (categories)
ICASB < 4	922	70 (7.6)	1 (Ref.)		1 (Ref)		1 (Ref.)		1 (Ref.)
ICASB 4–5	137	17 (12.4)	1.67 (0.98–2.84)	0.058	1.84 (1.07–3.14)	0.026	1.57 (0.88–2.79)	0.125	1.73 (1–2.99)	0.05
ICASB > 5	222	30 (13.5)	1.8 (1.18–2.76)	0.007	1.86 (1.18–2.92)	0.007	1.82 (1.14–2.92)	0.012	1.76 (1.1–2.81)	0.018
sICAS
Without sICAS	943	70 (7.4)	1 (Ref.)		1 (Ref.)		1 (Ref.)		1 (Ref.)
With sICAS	338	47 (13.9)	1.89 (1.31–2.74)	0.001	1.94 (1.32–2.84)	0.001	1.73 (1.16–2.59)	0.007	1.65 (1.1–2.46)	0.014

The effects of TyG, sICAS, and ICASB on ischemic stroke recurrence were analyzed using univariate and multifactorial Cox regression models. Model I was adjusted for age and sex, and model II was further adjusted for BMI, SBP, smoking status, time at onset, NIHSS score at arrival, WBC count, previous stroke, and previous diabetes mellitus. Model III was further adjusted for treatment during admission (antiplatelet and intensive statin therapy) and antihypertensive and hypoglycemic treatment on the basis of model II

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