Table 1 Risk for outcomes among matched patients with type 2 diabetes with microvascular diseases

New-onset CAD

1773

75,672

23.43

1869

76,191

24.53

1.05

(0.98, 1.12)

0.1481

1.06

(0.99, 1.13)

0.0777

New-onset stroke

1201

78,169

15.36

1311

78,737

16.65

1.08

(1, 1.17)

0.0416

1.11

(1.03, 1.2)

0.0088

New-onset heart failure

720

80,115

8.99

1012

80,058

12.64

1.41

(1.28, 1.55)

< 0.001

1.43

(1.3, 1.57)

< 0.001

Cardiovascular death

158

82,297

1.92

180

83,122

2.17

1.12

(0.9, 1.39)

0.3033

1.15

(0.93, 1.43)

0.1906

Outcome

Diabetic kidney disease

Diabetic neuropathy

n

PY

IR

n

PY

IR

cHR

(95% CI)

p-value

aHR^b

(95% CI)

p-value

New-onset CAD

2854

122,785

23.24

3062

122,898

24.92

1.07

(1.02, 1.13)

0.0067

1.07

(1.02, 1.13)

0.0064

New-onset stroke

1836

126,841

14.47

2128

126,765

16.79

1.16

(1.09, 1.24)

< 0.001

1.17

(1.1, 1.25)

< 0.001

New-onset heart Failure

1116

129,688

8.61

1110

131,228

8.46

0.98

(0.9, 1.07)

0.6568

1.01

(0.93, 1.1)

0.7501

Cardiovascular death

223

133,095

1.68

195

134,529

1.45

0.85

(0.7, 1.03)

0.0912

0.91

(0.75, 1.1)

0.3205

Outcome

Diabetic retinopathy

Diabetic neuropathy

n

PY

IR

n

PY

IR

cHR

(95% CI)

p-value

aHR^c

(95% CI)

p-value

New-onset CAD

1706

71,331

23.92

1724

70,846

24.33

1.02

(0.95, 1.09)

0.5902

1.02

(0.95, 1.09)

0.5749

New-onset stroke

1173

73,700

15.92

1281

72,661

17.63

1.11

(1.02, 1.2)

0.0114

1.12

(1.03, 1.21)

0.0065

New-onset heart failure

903

74,884

12.06

693

75,471

9.18

0.76

(0.69, 0.84)

< 0.001

0.79

(0.71, 0.87)

< 0.001

Cardiovascular death

152

77,710

1.96

134

77,519

1.73

0.88

(0.7, 1.11)

0.2873

0.91

(0.72, 1.16)

0.4553