Table 1 Baseline patient characteristics and MACEs (clinical outcome) in the development and validation cohorts.*,¶
Characteristic or Outcome | All cohort (n = 573) | Development cohort (n = 404) | Validation cohort (n = 169) | P |
|---|---|---|---|---|
Male sex | 469 (81.8%) | 326 (80.7%) | 143 (84.6%) | 0.321 |
Age, years | 58.0 [49.0;68.0] | 58.0 [48.0;68.0] | 58.0 [49.0;68.0] | 0.694 |
Hypertension | 268 (46.8%) | 177 (43.8%) | 91 (53.8%) | 0.035 |
Diabetes mellitus | 146 (25.5%) | 95 (23.5%) | 51 (30.2%) | 0.118 |
Current smoking | 250 (43.6%) | 180 (44.6%) | 70 (41.4%) | 0.550 |
Current drinking | 124 (21.6%) | 92 (22.8%) | 32 (18.9%) | 0.365 |
Family history of CAD | 69 (12.0%) | 51 (12.6%) | 18 (10.7%) | 0.602 |
Systolic blood pressure, mmHg | 120 [109;133] | 120 [109;132] | 121 [110;134] | 0.635 |
Diastolic blood pressure, mmHg | 76.4 (12.6) | 76.1 (12.3) | 77.1 (13.4) | 0.390 |
Heart rate, bpm | 80.0 [72.0;91.0] | 80.0 [71.0;91.0] | 81.0 [75.0;91.0] | 0.249 |
Body mass index, kg/m2 | 25.2 [23.4;27.7] | 25.2 [23.3;27.6] | 25.1 [23.4;27.8] | 0.947 |
Left ventricular end-diastolic dimension, mm | 50.0 [47.0;52.0] | 50.0 [47.0;52.2] | 50.0 [47.0;52.0] | 0.832 |
Left ventricular ejection fraction | 59.0 [55.0;63.0] | 59.0 [55.0;62.0] | 60.0 [56.0;63.0] | 0.129 |
Creatine kinase, U/L | 237 [102;856] | 254 [102;834] | 215 [102;856] | 0.587 |
Creatine kinase-MB, U/L | 28.0 [15.3;89.2] | 27.6 [15.4;91.8] | 28.4 [15.1;79.8] | 0.942 |
D-dimer, mg/L | 146 [91.0;281] | 146 [93.0;294] | 143 [89.0;260] | 0.531 |
Albumin, mg/dL | 40.0 [36.1;42.7] | 39.9 [36.1;43.2] | 40.2 [36.2;42.2] | 0.865 |
Low-density lipoprotein cholesterol, mmol/L | 2.96 [2.36;3.54] | 3.01 [2.39;3.55] | 2.88 [2.25;3.52] | 0.174 |
Total cholesterol, mmol/L | 4.65 [3.90;5.32] | 4.66 [3.85;5.32] | 4.61 [4.00;5.30] | 0.965 |
Fasting blood glucose, mmol/L | 8.06 [6.82;10.6] | 8.05 [6.81;10.6] | 8.06 [6.87;10.8] | 0.589 |
Triglyceride, mmol/L | 1.73 [1.13;2.87] | 1.72 [1.08;2.90] | 1.74 [1.22;2.78] | 0.701 |
Triglyceride glucose (TyG) index | 5.05 (0.40) | 5.05 (0.40) | 5.07 (0.39) | 0.557 |
MACEs | 96 (16.8%) | 68 (16.8%) | 28 (16.6%) | 1.000 |
All-cause mortality | 29 (5.06%) | 21 (5.20%) | 8 (4.73%) | 0.982 |
Re-myocardial infarction | 4 (0.70%) | 3 (0.74%) | 1 (0.59%) | 1.000 |
In-stent restenosis | 10 (1.75%) | 6 (1.49%) | 4 (2.37%) | 0.491 |
Revascularization | 64 (11.2%) | 45 (11.1%) | 19 (11.2%) | 1.000 |