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Fig. 9 | Cardiovascular Diabetology

Fig. 9

From: Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X

Fig. 9

Schematic illustration of WWP2 function in T2DM-induced vascular endothelial injury. Down-regulation of WWP2 triggered by JNK activation exacerbates T2DM-induced vascular endothelial injury through modulating K63-linked polyubiquitination and proteasomal degradation of DDX3X. p-JNK, phosphorylation of JNK; T2DM, Type 2 diabetes mellitus

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Cardiovascular Diabetology

ISSN: 1475-2840