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Table 2 Multivariable Cox regression analysis for assessing the independent predictors of MACEs at 1 year of follow-up

From: SGLT2-inhibitors effects on the coronary fibrous cap thickness and MACEs in diabetic patients with inducible myocardial ischemia and multi vessels non-obstructive coronary artery stenosis

Risk factors

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Hypertension

1.566

0.976–2.514

0.063

   

Smoking

2.489

0.907–6.831

0.077

   

HbA1c

3.100

2.206–9.854

0.001*

1.930

1.149–2.176

0.001*

IL-6

0.998

0.994–1.010

0.205

   

Minimum FCT

1.021

1.008–1.034

0.001*

1.007

0.994–1.020

0.306

Macrophage grade

1.244

1.140–1.357

0.001*

1.188

1.073–1.315

0.001*

SGLT2-I

0.271

1.218–4.232

0.001*

0.342

0.180–0.651

0.001*

  1. The total number of MACEs was 69 [n 12 (10.8%) in the SGLT2-I users vs. n 57 (22.1%) in the Non-SGLT2-I users; p < 0.05]
  2. MACEs major adverse cardiac events, HbA1c glycated hemoglobin, IL-6 interleukin 6, FCT fibrous cap thickness, SGLT2-I sodium glucose transporter 2 inhibitors
  3. *Statistical significant (p < 0.05)
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Cardiovascular Diabetology

ISSN: 1475-2840