Skip to main content

Table 3 Association of change in high-density lipoprotein cholesterol levels with incident cardiovascular disease according to the change in low-density lipoprotein cholesterol levels

From: Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants

 

Change in HDL-C (mg/dL)

P for trend

1st quartile,

≤-2

2nd quartile,

-1 to + 6

3rd quartile,

+ 7 to + 14

4th quartile,

≥+15

Cardiovascular disease

    

LDL-C decreasea

     

aHR (95% CI)

1.00 (reference)

1.04 (0.92–1.18)

1.05 (0.93–1.19)

1.10 (0.98–1.25)

0.441

P value

 

0.551

0.441

0.109

 

LDL-C increaseb

     

aHR (95% CI)

1.00 (reference)

1.07 (0.94–1.21)

1.13 (1.00–1.27)

1.23 (1.09–1.39)

0.008

P value

 

0.319

0.060

< 0.001

 

Coronary heart disease

    

LDL-C decreasea

     

aHR (95% CI)

1.00 (reference)

1.28 (1.04–1.57)

1.23 (1.00–1.51)

1.26 (1.03–1.53)

0.078

P value

 

0.018

0.054

0.024

 

LDL-C increaseb

     

aHR (95% CI)

1.00 (reference)

1.09 (0.89–1.34)

1.07 (0.87–1.31)

1.34 (1.10–1.63)

0.017

P value

 

0.390

0.543

0.003

 

Stroke

     

LDL-C decreasea

     

aHR (95% CI)

1.00 (reference)

0.95 (0.81–1.11)

0.97 (0.82–1.13)

1.03 (0.88–1.19)

0.735

P value

 

0.515

0.669

0.735

 

LDL-C increaseb

     

aHR (95% CI)

1.00 (reference)

1.06 (0.91–1.24)

1.18 (1.02–1.37)

1.18 (1.01–1.37)

0.077

P value

 

0.430

0.028

0.034

 
  1. Data are hazard ratio (95% confidence interval) calculated using the Cox proportional hazards model after adjustments for age, sex, household income, body mass index, hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol consumption, moderate-to-vigorous physical activity, and Charlson comorbidity index
  2. aWith change in LDL-C level of < 0 in the second health screening (2011–2012) compared to the first health screening (2009–2010)
  3. bWith change in LDL-C level of ≥ 0 in the second health screening (2011–2012) compared to the first health screening (2009–2010)
  4. Acronyms: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840