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Table 3 The additional predictive value of uACR for heart failure

From: Elevated urine albumin-to-creatinine ratio increases the risk of new-onset heart failure in patients with type 2 diabetes

 

AUC

P-value

NRI

P-value

IDI

P-value

Model 2

0.680 (0.665, 0.715)

Ref.

Ref.

Model 2 + ln(uACR)

0.783 (0.754, 0.813)

 < 0.001

0.330 (0.237, 0.404)

 < 0.001

0.034 (0.022, 0.052)

 < 0.001

Model 2 + uACR categories

0.768 (0.737, 0.799)

 < 0.001

0.362 (0.296, 0.424)

 < 0.001

0.024 (0.014, 0.039)

 < 0.001

Model 4

0.744 (0.710, 0.776)

Ref.

Ref.

Model 4 + ln(uACR)

0.802 (0.773, 0.832)

 < 0.001

0.291 (0.200, 0.369)

 < 0.001

0.037 (0.021, 0.061)

 < 0.001

Model 4 + uACR categories

0.793 (0.763, 0.823)

 < 0.001

0.284 (0.209, 0.358)

 < 0.001

0.025 (0.012, 0.042)

 < 0.001

Model 5

0.755 (0.721, 0.788)

Ref.

Ref.

Model 5 + ln(uACR)

0.807 (0.777, 0.837)

 < 0.001

0.285 (0.182, 0.347)

 < 0.001

0.039 (0.021, 0.060)

 < 0.001

Model 5 + uACR categories

0.798 (0.767, 0.830)

 < 0.001

0.303 (0.231, 0.375)

 < 0.001

0.025 (0.012, 0.042)

 < 0.001

  1. Model 2: age, sex; Model 4 (WATCH-DM risk score): age, BMI, SBP, DBP, FPG, serum creatinine, HDL cholesterol, CHD; Model 5(Williams et al. study model): age, SBP, CHD, Atrial fibrillation, HbA1c, Albumin, BUN, eGFR, smoking;
  2. uACR urine albumin-to-creatinine ratio, AUC the area under the receiver operating characteristic curve, NRI net reclassification improvement, IDI integrated discrimination improvement