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Table 4 Association analyses for carotid atherosclerosis with multi-locus genetic risk scores (GRS)

From: Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case–control study

Variable

CP-negative (n = 439)

CP-positive (n = 309)

Multivariable

n (%)

n (%)

ORa (95% CI)

9-locus GRSb

   

Mean (SD)

8.62 (1.63)

9.19 (1.53)

 

GRS

   

 4–6

45 (10.3)

12 (3.9)

1.00

 7–8

160 (46.7)

80 (25.9)

1.91+ (0.92–3.97)

 9–10

179 (40.8)

152 (49.2)

3.37** (1.65–6.89)

 ≥ 11

55 (12.5)

65 (21.0)

5.59*** (2.56–12.19)

Per 1.0 risk score

  

1.30*** (1.18–1.44)

4-locus GRSc

   

Mean (SD)

3.78 (0.92)

4.02 (0.81)

 

GRS

   

 0–2

35 (8.0)

9 (2.9)

1.00

 3

119 (27.1)

68 (22.0)

2.02 (0.87–4.74)

 4

187 (42.6)

138 (44.7)

2.94* (1.29–6.69)

 5

98 (22.3)

94 (30.4)

4.04*** (1.74–9.40)

Per 1.0 risk score

  

1.47*** (1.22–1.77)

  1. aORs were adjusted for age, sex, cigarette smoking, and hypertension
  2. brs4712524-rs1150777-rs10842993-rs2858980-rs9583907-rs1077476-rs7180016-rs4383154-rs9937354
  3. crs10842993- rs7180016-rs4383154-rs9937354
  4. +0.05 < p < 0.1; *0.005 < p < 0.05; **0.0001 < p < 0.005; ***p < 0.0001