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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways

Fig. 5

Maternal obesity globally affects postnatal development pathways. a Venn diagram showing the intersection between the DMPs that change at least in one longitudinal comparison preserving the direction of the change (Dev) and the CpGs found in the Ob.C DMRs. b Venn diagrams depicting the overlaps between aforementioned CpGs, separated by the direction of the methylation change. c Sankey diagram describing the distribution of Dev DMPs when considering the changes between Ob and C subjects. d Sankey diagram showing the distribution of those Dev DMPs that experience hyper- and hypo- changes between Ob and C subjects. e Bubble plots showing the top 5 most significant GO BP and CGP gene sets (FDR < 0.05) for the Dev DMPs based on their methylation patterns between Ob and C subjects

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Cardiovascular Diabetology

ISSN: 1475-2840