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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways

Fig. 1

Development is the main origin of methylation changes during the first year of life. a Schematic of the study design. b Scatter plot showing the PCA of the subjects according to their methylation values at the top 100,000 most variable CpG sites. c Violin plots describing the distribution of methylation values at the 772,088 CpGs analysed by time point. d Barplots depicting the number of hyper- and hypomethylated DMPs (FDR < 0.05) found in 0 > 6 and 6 > 12 longitudinal comparisons. e At the top, a Venn diagram showing the intersections between 0 > 6 and 6 > 12 DMPs. At the bottom, a Venn diagram describing the intersection between hyper- and hypomethylated DMPs at 0 > 6 and 6 > 12 comparisons. f Barplots showing the relative distribution of hyper- and hypomethylated DMPs at 0 > 6 and 6 > 12 comparisons according to their CpG island location status. g Barplots showing the relative distribution of hyper- and hypomethylated DMPs at 0 > 6 and 6 > 12 comparisons according to their gene location status. Rightmost bars represent the background distribution considering all 772,088 probes analysed

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Cardiovascular Diabetology

ISSN: 1475-2840