Skip to main content

Table 3 Adjusted HRs of cardiovascular outcomes across the spectrum of diabetes status and NT-proBNP categories

From: The joint association of diabetes status and NT-ProBNP with adverse cardiac outcomes in patients with non-ST-segment elevation acute coronary syndrome: a prospective cohort study

Diabetes status

NT-proBNP

T1 (< 92 pg/ml)

T2 (92–335 pg/ml)

T3 (≥ 336 pg/ml)

P value for trend

n/N

HR (95% CI) *

n/N

HR (95% CI) *

n/N

HR (95% CI) *

MACCEs

       

 Normoglycemia

34/687

Ref.

51/637

1.28 (0.83–1.98)

103/524

2.11 (1.40–3.17)

0.001

 Prediabetes

60/822

1.52 (1.00–2.32)

68/777

1.40 (0.92–2.12)

161/761

2.24 (1.51–3.32)

 < 0.001

 Diabetes

87/1144

1.51 (1.01–2.25)

171/1241

2.15 (1.47–3.13)

335/1363

2.67 (1.83–3.89)

 < 0.001

 P value for trend

 

0.702

 

0.004

 

 < 0.001

 

All-cause mortality

       

 Normoglycemia

9/687

Ref.

11/637

0.78 (0.32–1.89)

59/524

2.40 (1.16–4.98)

 < 0.001

 Prediabetes

10/822

0.90 (0.36–2.21)

17/777

0.98 (0.43–2.21)

92/761

2.32 (1.13–4.75)

 < 0.001

 Diabetes

15/1144

0.91 (0.40–2.08)

59/1241

1.91 (0.94–3.90)

189/1363

2.98 (1.48–6.00)

 < 0.001

 P value for trend

 

0.056

 

0.442

 

 < 0.001

 
  1. *Estimates were adjusted for age, sex, BMI, NSTE-ACS status, previous hypertension, previous dyslipidemia, previous myocardial infarction, systolic blood pressure, heart rate, LVEF, eGFR, hs-CRP, LDL-C, smoking status, and in-hospital treatments (PCI, antiplatelet therapy, β-blocker, ACEI or ARB, and statins); Statistically significant estimates in bold
  2. Abbreviations see Table 1
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840