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Table 1 Baseline and clinical characteristics by NT-proBNP categories

From: The joint association of diabetes status and NT-ProBNP with adverse cardiac outcomes in patients with non-ST-segment elevation acute coronary syndrome: a prospective cohort study

 

Total

T1 (< 92 pg/ml)

T2 (92–335 pg/ml)

T3 (≥ 336 pg/ml)

P value

Number

7956

2653

2655

2648

 

Clinical characteristics

     

 Age, year

65.4 ± 10.5

60.8 ± 8.6

65.9 ± 9.7

69.6 ± 11.0

 < 0.001

 Male, n (%)

4986 (62.7)

1885 (71.1)

1547 (58.3)

1554 (58.7)

 < 0.001

 BMI, kg/m2

25.9 ± 3.6

26.2 ± 3.4

26.0 ± 3.7

25.5 ± 3.7

 < 0.001

 Heart rate, bpm

71.4 ± 12.2

71.3 ± 10.6

69.6 ± 10.9

73.3 ± 14.5

 < 0.001

 SBP, mmHg

132.9 ± 18.1

130.1 ± 15.5

133.7 ± 17.5

135.1 ± 20.7

 < 0.001

 DBP, mmHg

75.6 ± 11.6

77.1 ± 11.1

75.3 ± 11.4

74.4 ± 12.0

 < 0.001

Diabetes status, n (%)

     

 Normoglycemia

1848 (23.2)

687 (25.9)

637 (24.0)

524 (19.8)

 < 0.001

 Prediabetes

2360 (29.7)

822 (31.0)

777 (29.3)

761 (28.7)

 

 Diabetes

3748 (47.1)

1144 (43.1)

1241 (46.7)

1363 (51.5)

 

Previous hypertension, n (%)

5736 (72.1)

1786 (67.3)

1955 (73.6)

1995 (75.3)

 < 0.001

Previous dyslipidemia, n (%)

3861 (48.5)

1357 (51.1)

1335 (50.3)

1169 (44.1)

 < 0.001

Previous MI, n (%)

630 (7.9)

114 (4.3)

201 (7.6)

315 (11.9)

 < 0.001

Previous stroke, n (%)

1462 (18.4)

350 (13.2)

501 (18.9)

611 (23.1)

 < 0.001

Previous PCI, n (%)

1200 (15.1)

318 (12.0)

429 (16.2)

453 (17.1)

 < 0.001

Current smoker, n (%)

2606 (32.8)

997 (37.6)

791 (29.8)

818 (30.9)

 < 0.001

LVEF, %

65.6 ± 6.8

67.6 ± 4.8

66.6 ± 5.9

62.5 ± 8.1

 < 0.001

NSTE-ACS status, n (%)

     

 UA

6183 (77.7)

2532 (95.4)

2271 (85.5)

1380 (52.1)

 < 0.001

 NSTEMI

1773 (22.3)

121 (4.6)

384 (14.5)

1268 (47.9)

 

Laboratory examinations

     

 FPG, mmol/L

6.1 ± 2.2

6.0 ± 1.9

6.1 ± 2.1

6.3 ± 2.4

 < 0.001

 HbA1c, %

6.5 ± 1.4

6.4 ± 1.3

6.5 ± 1.4

6.6 ± 1.4

 < 0.001

 Hemoglobin, g/l

133.9 ± 17.9

140.1 ± 15.1

133.4 ± 16.2

128.2 ± 20.1

 < 0.001

 eGFR, ml/min/1.73m2

112.7 ± 30.5

124.0 ± 27.0

113.7 ± 28.5

100.4 ± 31.2

 < 0.001

 eGFR < 60 ml/min/1.73m2, n (%)

324 (4.1)

16 (0.6)

65 (2.4)

243 (9.2)

 < 0.001

 hs-CRP, mg/l

1.7 (0.7, 5.3)

1.1 (0.5, 2.8)

1.4 (0.6, 3.9)

3.4 (1.2, 12.3)

 < 0.001

 hs-CRP ≥ 3 mg/l, n (%)

2696 (33.9)

568 (21.4)

785 (29.6)

1343 (50.7)

 < 0.001

 Peak value of NT-proBNP, pg/ml

165.0 (65.8, 527.5)

46.9 (29.7, 65.8)

165.0 (122.0, 227.0)

983.5 (528.0, 2380.0)

 < 0.001

 Triglyceride, mmol/l

1.36 (0.99, 1.93)

1.46 (1.05, 2.04)

1.37 (1.00, 1.95)

1.28 (0.94, 1.81)

 < 0.001

 Total cholesterol, mmol/l

4.23 ± 1.05

4.21 ± 1.03

4.23 ± 1.04

4.26 ± 1.09

0.320

 LDL-C, mmol/l

2.39 ± 0.75

2.36 ± 0.72

2.37 ± 0.75

2.42 ± 0.78

0.007

 HDL-C, mmol/l

1.09 ± 0.27

1.08 ± 0.25

1.10 ± 0.27

1.07 ± 0.27

 < 0.001

In-hospital treatment, n (%)

     

 Aspirin

7125 (89.6)

2416 (91.1)

2418 (91.1)

2291 (86.5)

 < 0.001

 Clopidogrel/Ticagrelor

4420 (55.6)

1212 (45.7)

1447 (54.5)

1761 (66.5)

 < 0.001

 β-Blocker

5240 (65.9)

1648 (62.1)

1705 (64.2)

1887 (71.3)

 < 0.001

 ACEI/ARB

4222 (53.1)

1155 (43.5)

1404 (52.9)

1663 (62.8)

 < 0.001

 Statins

7064 (88.8)

2387 (90.0)

2377 (89.5)

2300 (86.9)

 < 0.001

 PCI

3957 (49.7)

1145 (43.2)

1339 (50.4)

1473 (55.6)

 < 0.001

  1. Values are mean ± SD, n (%), or median (interquartile interval)
  2. ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; LVEF, left ventricular ejection fraction; MI, myocardial infarction; NSTEMI, non-ST-segment elevation myocardial infarction; NSTE-ACS, non-ST-segment elevation acute coronary syndrome; NT-proBNP, N-terminal pro-B-type natriuretic peptide; PCI, percutaneous coronary intervention; SBP, systolic blood pressure; UA, unstable angina