LDL-cholesterol, mg/dL | N | Event | Duration | IR, per 1000 | Adjusted HR |
---|---|---|---|---|---|
Whole cohort | |||||
 < 70 | 343,781 | 4313 | 2,335,003 | 1.847 | 1 (Ref.) |
 < 75 | 305,842 | 3283 | 2,083,277 | 1.575 | 0.884 (0.844–0.925) |
 < 100 | 389,404 | 4033 | 2,668,129 | 1.511 | 0.884 (0.846–0.923) |
 < 115 | 415,948 | 3969 | 2,857,482 | 1.388 | 0.843 (0.806–0.881) |
 < 130 | 380,029 | 3602 | 2,618,974 | 1.375 | 0.871 (0.832–0.912) |
 < 145 | 297,720 | 2768 | 2,052,509 | 1.348 | 0.898 (0.855–0.943) |
 < 160 | 203,636 | 1798 | 1,405,373 | 1.279 | 0.896 (0.847–0.947) |
 ≥ 160 | 266,217 | 2575 | 1,831,046 | 1.406 | 1.059 (1.007–1.113) |
Male | |||||
 < 70 | 235,091 | 3420 | 1,587,304 | 2.154 | 1 (Ref.) |
 < 75 | 192,013 | 2390 | 1,299,316 | 1.839 | 0.852 (0.809–0.898) |
 < 100 | 242,681 | 2936 | 1,652,335 | 1.776 | 0.861 (0.819–0.905) |
 < 115 | 256,338 | 2838 | 1,750,195 | 1.621 | 0.817 (0.777–0.860) |
 < 130 | 227,758 | 2482 | 1,560,248 | 1.590 | 0.837 (0.794–0.883) |
 < 145 | 170,905 | 1843 | 1,170,216 | 1.574 | 0.867 (0.819–0.919) |
 < 160 | 110,355 | 1152 | 755,774 | 1.524 | 0.880 (0.822–0.941) |
 ≥ 160 | 127,157 | 1503 | 865,297 | 1.736 | 1.058 (0.995–1.125) |
Female | |||||
 < 70 | 108,690 | 893 | 747,698 | 1.194 | 1 (Ref.) |
 < 75 | 113,829 | 893 | 783,961 | 1.139 | 1.002 (0.913–1.100) |
 < 100 | 146,723 | 1097 | 1,015,794 | 1.079 | 0.979 (0.895–1.070) |
 < 115 | 159,610 | 1131 | 1,107,286 | 1.021 | 0.943 (0.862–1.032) |
 < 130 | 152,271 | 1120 | 1,058,726 | 1.057 | 0.994 (0.908–1.088) |
 < 145 | 126,815 | 925 | 882,293 | 1.048 | 1.007 (0.916–1.107) |
 < 160 | 93,281 | 646 | 649,599 | 0.994 | 0.973 (0.877–1.079) |
 ≥ 160 | 139,060 | 1072 | 965,748 | 1.110 | 1.125 (1.028–1.232) |
BMI < 25 | |||||
 < 70 | 179,832 | 2746 | 1,198,668 | 2.290 | 1 (Ref.) |
 < 75 | 163,692 | 2037 | 1,100,486 | 1.851 | 0.843 (0.796–0.893) |
 < 100 | 207,600 | 2486 | 1,407,077 | 1.766 | 0.828 (0.784–0.875) |
 < 115 | 217,849 | 2409 | 1,482,357 | 1.625 | 0.776 (0.734–0.821) |
 < 130 | 194,372 | 2175 | 1,328,505 | 1.637 | 0.804 (0.759–0.852) |
 < 145 | 147,945 | 1604 | 1,011,792 | 1.585 | 0.809 (0.759–0.861) |
 < 160 | 98,373 | 1060 | 674,577 | 1.571 | 0.837 (0.779–0.899) |
 ≥ 160 | 125,585 | 1457 | 857,366 | 1.699 | 0.974 (0.913–1.039) |
BMI ≥ 25 | |||||
 < 70 | 163,949 | 1567 | 1,136,334 | 1.379 | 1 (Ref.) |
 < 75 | 142,150 | 1246 | 982,791 | 1.267 | 0.952 (0.884–1.026) |
 < 100 | 181,804 | 1547 | 1,261,051 | 1.226 | 0.978 (0.911–1.050) |
 < 115 | 198,099 | 1560 | 1,375,125 | 1.134 | 0.954 (0.888–1.025) |
 < 130 | 185,657 | 1427 | 1,290,468 | 1.105 | 0.979 (0.909–1.054) |
 < 145 | 149,775 | 1164 | 1,040,716 | 1.118 | 1.043 (0.965–1.128) |
 < 160 | 105,263 | 738 | 730,795 | 1.009 | 0.987 (0.902–1.079) |
 ≥ 160 | 140,632 | 1118 | 973,679 | 1.148 | 1.194 (1.104–1.292) |
Statin naïve | |||||
 < 70 | 166,004 | 2195 | 1,124,450 | 1.952 | 1 (Ref.) |
 < 75 | 176,963 | 1906 | 1,200,642 | 1.587 | 0.810 (0.761–0.861) |
 < 100 | 269,908 | 2744 | 1,845,959 | 1.486 | 0.781 (0.738–0.826) |
 < 115 | 322,591 | 2959 | 2,213,922 | 1.336 | 0.729 (0.689–0.771) |
 < 130 | 307,768 | 2816 | 2,117,839 | 1.329 | 0.758 (0.717–0.802) |
 < 145 | 237,304 | 2127 | 1,633,582 | 1.302 | 0.784 (0.738–0.832) |
 < 160 | 152,870 | 1316 | 1,051,772 | 1.251 | 0.794 (0.741–0.851) |
 ≥ 160 | 167,722 | 1617 | 1,148,656 | 1.407 | 0.963 (0.902–1.028) |
Statin use | |||||
 < 70 | 177,777 | 2118 | 1,210,552 | 1.749 | 1 (Ref.) |
 < 75 | 128,879 | 1377 | 882,635 | 1.560 | 0.954 (0.892–1.021) |
 < 100 | 119,496 | 1289 | 822,169 | 1.567 | 1.020 (0.951–1.093) |
 < 115 | 93,357 | 1010 | 643,559 | 1.569 | 1.062 (0.985–1.145) |
 < 130 | 72,261 | 786 | 501,135 | 1.568 | 1.109 (1.022–1.204) |
 < 145 | 60,416 | 641 | 418,926 | 1.530 | 1.127 (1.031–1.232) |
 < 160 | 50,766 | 482 | 353,600 | 1.363 | 1.060 (0.960–1.171) |
 ≥ 160 | 98,495 | 958 | 682,389 | 1.403 | 1.198 (1.108–1.295) |
Insulin naïve | |||||
 < 70 | 302,401 | 3272 | 2,071,675 | 1.579 | 1 (Ref.) |
 < 75 | 272,445 | 2562 | 1,867,817 | 1.371 | 0.886 (0.842–0.934) |
 < 100 | 352,287 | 3204 | 2,427,033 | 1.320 | 0.875 (0.833–0.920) |
 < 115 | 380,823 | 3266 | 2,628,009 | 1.242 | 0.845 (0.804–0.888) |
 < 130 | 351,133 | 2929 | 2,428,968 | 1.205 | 0.849 (0.806–0.893) |
 < 145 | 276,886 | 2299 | 1,915,834 | 1.200 | 0.884 (0.837–0.934) |
 < 160 | 190,250 | 1502 | 1,316,982 | 1.140 | 0.882 (0.829–0.939) |
 ≥ 160 | 248,411 | 2123 | 1,714,647 | 1.238 | 1.039 (0.982–1.098) |
Insulin use | |||||
 < 70 | 41,380 | 1041 | 263,327 | 3.953 | 1 (Ref.) |
 < 75 | 33,397 | 721 | 215,460 | 3.346 | 0.874 (0.795–0.962) |
 < 100 | 37,117 | 829 | 241,096 | 3.438 | 0.918 (0.837–1.007) |
 < 115 | 35,125 | 703 | 229,473 | 3.063 | 0.826 (0.749–0.911) |
 < 130 | 28,896 | 673 | 190,006 | 3.541 | 0.978 (0.885–1.080) |
 < 145 | 20,834 | 469 | 136,675 | 3.431 | 0.963 (0.862–1.076) |
 < 160 | 13,386 | 296 | 88,390 | 3.348 | 0.971 (0.852–1.107) |
 ≥ 160 | 17,806 | 452 | 1,16,398 | 3.883 | 1.169 (1.045–1.308) |