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Table 3 Prospective associations between the TG/HDL-C ratio and risk of cardiovascular disease in the UK Biobank

From: Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data

 

TG/HDL-C ratio

P trend

Per 1 SD increase

Quartile 1

Quartile 2

Quartile 3

Quartile 4

in Log TG/HDL-C values

Median

1.11

1.90

3.01

5.51

  

Cardiovascular disease

 No. of cases/person-years

2817/811,994

4197/807,320

5471/803,410

7269/799,568

 < 0.001

 

 Model 1, HR (95% CI)

1.00

1.50 (1.43–1.57)

1.96 (1.88–2.06)

2.62 (2.51–2.74)

 < 0.001

1.40 (1.38–1.42)

 Model 2, HR (95% CI)

1.00

1.27 (1.21–1.34)

1.51 (1.44–1.58)

1.91 (1.82–1.99)

 < 0.001

1.27 (1.25–1.29)

 Model 3, HR (95% CI)

1.00

1.07 (1.02–1.13)

1.13 (1.07–1.18)

1.29 (1.23–1.36)

 < 0.001

1.12 (1.10–1.13)

Coronary heart disease

 No. of cases/person-years

2165/814,334

3404/810,261

4569/806,749

6266/803,386

 < 0.001

 

 Model 1, HR (95% CI)

1.00

1.58 (1.50–1.67)

2.13 (2.03–2.24)

2.94 (2.80–3.08)

 < 0.001

1.45 (1.43–1.48)

 Model 2, HR (95% CI)

1.00

1.34 (1.27–1.41)

1.63 (1.55–1.72)

2.11 (2.01–2.22)

 < 0.001

1.32 (1.30–1.34)

 Model 3, HR (95% CI)

1.00

1.11 (1.05–1.17)

1.18 (1.11–1.24)

1.37 (1.30–1.45)

 < 0.001

1.15 (1.13–1.18)

Stroke

 No. of cases/person-years

739/907,452

919/907,214

1074/907,801

1244/910,805

 < 0.001

 

 Model 1, HR (95% CI)

1.00

1.24 (1.13–1.37)

1.45 (1.32–1.60)

1.68 (1.53–1.84)

 < 0.001

1.19 (1.16–1.23)

 Model 2, HR (95% CI)

1.00

1.07 (0.97–1.17)

1.14 (1.04–1.26)

1.29 (1.17–1.41)

 < 0.001

1.09 (1.05–1.13)

 Model 3, HR (95% CI)

1.00

0.97 (0.88–1.08)

0.97 (0.88–1.08)

1.02 (0.92–1.14)

0.34

1.00 (0.96–1.04)

  1. TG/HDL-C, triglyceride to high-density lipoprotein cholesterol; HR, hazard ratio
  2. Model 1: an unadjusted model
  3. Model 2: adjusted for age, sex, ethnicity (White and others), region (England, Scotland, and Wales), and Townsend Deprivation Index
  4. Model 3: further adjusted for current smoking (yes or no), physical activity (< 150 or  ≥ 150 min/week), body mass index (kg/m2), systolic blood pressure (mm Hg), total cholesterol (mg/dL), low-density lipoprotein cholesterol (mg/dL), uric acid (mg/dL), glycated hemoglobin (mmol/mol), estimated glomerular filtration rate (mL/min/1.73 m2), high sensitivity C-reactive protein (mg/L), aspirin use (yes or no), insulin treatment (yes or no), antihypertensive medication (yes or no), cholesterol-lowering medication (yes or no), prevalent retinopathy (yes or no), and chronic kidney disease (yes or no)
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Cardiovascular Diabetology

ISSN: 1475-2840