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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis

Fig. 3

Effects of empagliflozin on Na+/H+ exchanger (NHE) and downstream signaling. A Averaged data of the intracellular pH in the control cells and empagliflozin (1 μmol/L)-treated atrial fibroblasts cotreated with or without cariporide (10 μmol/L) for 48 h (n = 6 experiments, statistic test by one-way repeated measures ANOVA). B Photographs and averaged data of the expression of pro-collagen type I, type III, phosphorylated phospholipase C (pPLC), and NHE1 protein in control cells and empagliflozin (1 μmol/L)-treated atrial fibroblasts cotreated with or without cariporide (10 μmol/L) for 48 h (n = 6 experiments, statistic test by one-way repeated measures ANOVA). GAPDH was used as loading control. * p < 0.05, $ p < 0.005

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