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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors

Fig. 6

Gene expression and dna methylation of NF-kB AND SOD2 in transient SGLT2 gene silencing. A, B qPCR for NF-kB and SOD2 in SGLT2 siRNA-transfected AC16 cells exposed to glucose concentration for 7 days. NG = cells exposed to NG concentration, HG = cells exposed to HG concentration for 7 days, HG + EMPA = cells exposed to HG concentration and treated with EMPA; HG + SCR = scrambled siRNA-transfected cells exposed for 7 days to HG; HG + siRNA = SGLT2 siRNA-transfected AC16 cells exposed to HG concentration for 7 days; and HG + siRNA + EMPA = GLT2 siRNA-transfected AC16 cells exposed to 33 mM glucose concentration for 7 days. Data are mean ± SD. * P < 0.05 vs CTR; ** P < 0.05 vs HG.

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