Fig. 2

The mechanism of PCSK9 synthesis inhibition by inclisiran. Inclisiran, GalNAc‐conjugated siRNA, binds to the asialoglycoprotein receptor on the surface of hepatocytes with high selectivity, which can be delivered into the cell via endocytosis. The antisense strand of the siRNA duplex is incorporated into the RNA-induced silencing complex intracellularly, which cleaves mRNA encoding PCSK9 specifically. The inhibition of PCSK9 synthesis reduces the degradation of LDL receptors. RISC ribonucleic acids‐induced silencing complex, ASGPRs asialoglycoprotein receptors, GalNAc N-acetyl galactosamine