Fig. 7
From: Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis
ASMase deficiency reduces NAPDH oxidase activity and apoptosis in HFD mice. a–d Representative Western blot images and densitometric analysis of ASMase, NOX2 and NOX4 protein levels in ASMaseMyh6KO and control mice treated with or without HFD. e Representative immumohistochemical staining of ceramide in myocardium of mice (scale bar:100 μm). f–g Representative fluorescence images and quantitative analysis of TUNEL staining (scale bar:100 μm). Data were presented as Mean ± SEM, n = 4. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001