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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion

Fig. 4

Deletion of Tbc1d4 leads to increased extracellular matrix area and impaired Mmp expression profile. Transmission electron microscopy of A WT and B Tbc1d4-deficient cardiac left ventricular tissue and C histomorphometrical analysis of extracellular matrix area. Expression of ECM remodeling markers in terms of D Mmp2, E Mmp9, F Mmp13 and G Mmp2/Timp1 ratio. Data presented as mean ± SEM (n = 3). Statistical analysis was performed using unpaired two-tailed student’s t-Test (C-G; WT vs. D4KO: *p < 0.05; ***p < 0.001). WT wild type, D4KO Tbc1d4-knockout

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