Categories | Overall | Q1 | Q2 | Q3 | Q4 | P-value |
---|---|---|---|---|---|---|
(N = 1618) | (N = 389) | (N = 412) | (N = 410) | (N = 407) | ||
Age, years | 68.05 (14.05) | 70.38 (14.50) | 69.46 (14.08) | 67.80 (13.72) | 64.66 (13.28) |  < 0.001 |
Male, n (%) | 1054 (65.14) | 262 (67.35) | 264 (64.08) | 266 (64.88) | 262 (64.37) | 0.762 |
BMI, kg/m2 | 29.60 (14.85) | 29.03 (23.79) | 28.99 (11.18) | 28.86 (6.38) | 31.40 (13.44) | 0.180 |
SOFA score | 3.00 (2.58) | 2.62 (2.22) | 2.71 (2.22) | 3.21 (2.65) | 3.43 (3.04) |  < 0.001 |
SIRS score | 2.43 (1.05) | 2.27 (1.02) | 2.35 (1.05) | 2.53 (1.04) | 2.55 (1.07) |  < 0.001 |
APSIII | 37.29 (17.14) | 36.02 (15.26) | 35.68 (15.60) | 37.70 (17.51) | 39.72 (19.55) | 0.003 |
SAPSII | 32.45 (12.62) | 31.50 (11.55) | 31.98 (11.50) | 33.15 (13.03) | 33.12 (14.15) | 0.159 |
Comorbidities, n (%) | ||||||
 Heart failure | 651 (40.23) | 143 (36.76) | 158 (38.35) | 165 (40.24) | 185 (45.45) | 0.067 |
 Hypertension | 866 (53.52) | 195 (50.13) | 228 (55.34) | 220 (53.66) | 223 (54.79) | 0.455 |
 Atrial fibrillation | 401 (24.78) | 114 (29.31) | 100 (24.27) | 101 (24.63) | 86 (21.13) | 0.064 |
 Dyslipidemia | 420 (25.96) | 94 (24.16) | 106 (25.73) | 97 (23.66) | 123 (30.22) | 0.131 |
Diabetes | 484 (29.91) | 47 (12.08) | 77 (18.69) | 140 (34.15) | 220 (54.05) |  < 0.001 |
 Respiratory failure | 183 (11.31) | 27 (6.94) | 33 (8.01) | 57 (13.90) | 66 (16.22) |  < 0.001 |
 AKIb | 830 (51.30) | 181 (46.53) | 182 (44.17) | 228 (55.61) | 239 (58.72) |  < 0.001 |
 CKD | 179 (11.06) | 43 (11.05) | 38 (9.22) | 45 (10.98) | 53 (13.02) | 0.390 |
 AMI | 1,126 (69.65) | 264 (67.87) | 289 (70.15) | 282 (68.78) | 291 (71.50) | 0.698 |
 PCI | 1,127 (69.65) | 261 (67.10) | 286 (69.42) | 292 (71.22) | 288 (70.76) | 0.588 |
 CABG | 186 (11.50) | 41 (10.54) | 35 (8.50) | 64 (15.61) | 46 (11.30) | 0.013 |
Laboratory tests | ||||||
 WBC, K/uL | 11.76 (5.04) | 10.91 (4.61) | 11.33 (5.03) | 11.88 (4.64) | 12.87 (5.59) |  < 0.001 |
 Lymphocyte, % | 15.24 (9.92) | 15.69 (11.10) | 15.37 (10.40) | 14.72 (8.72) | 15.25 (9.48) | 0.699 |
 Neutrophil, % | 77.80 (12.16) | 77.67 (13.16) | 77.04 (12.71) | 78.36 (10.68) | 78.04 (12.16) | 0.612 |
 RBC, m/uL | 4.17 (0.68) | 4.10 (0.68) | 4.18 (0.62) | 4.18 (0.68) | 4.23 (0.74) | 0.040 |
 Platelet, K/uL | 250.27 (96.86) | 245.36 (104.94) | 249.52 (88.84) | 252.96 (98.43) | 253.00 (95.15) | 0.645 |
 Hemoglobin, g/dL | 12.67 (2.07) | 12.46 (2.01) | 12.73 (1.95) | 12.69 (2.13) | 12.77 (2.15) | 0.150 |
 Serum potassium, mEq/L | 4.22 (0.77) | 4.15 (0.68) | 4.22 (0.75) | 4.18 (0.76) | 4.34 (0.87) | 0.004 |
 Serum sodium, mEq/L | 138.23 (4.00) | 138.09 (4.52) | 138.67 (3.53) | 138.11 (3.81) | 138.03 (4.07) | 0.078 |
 TC, mg/dL | 161.20 (46.30) | 148.67 (42.10) | 161.24 (48.04) | 165.06 (45.82) | 169.44 (46.53) |  < 0.001 |
 TG, mg/dL | 132.82 (89.64) | 64.82 (22.25) | 101.80 (28.19) | 134.34 (45.68) | 227.71 (119.13) |  < 0.001 |
 LDL, mg/dL | 90.99 (39.95) | 85.43 (35.95) | 94.35 (42.71) | 95.15 (39.97) | 88.63 (40.04) | 0.001 |
 HDL, mg/dL | 45.05 (14.21) | 50.65 (15.15) | 46.46 (13.66) | 43.60 (13.38) | 39.54 (12.27) |  < 0.001 |
 HbA1c, % | 6.45 (1.42) | 5.95 (0.98) | 6.04 (0.79) | 6.25 (1.19) | 7.47 (1.85) |  < 0.001 |
 Glucose, mg/dL | 165.39 (86.07) | 134.58 (51.49) | 146.48 (52.93) | 166.13 (83.95) | 213.46 (116.12) |  < 0.001 |
 Albumin, g/dL | 3.49 (0.58) | 3.48 (0.54) | 3.48 (0.60) | 3.50 (0.54) | 3.49 (0.63) | 0.967 |
 Ucr, mg/dL | 95.46 (65.61) | 98.04 (66.63) | 99.33 (60.41) | 89.65 (62.52) | 95.71 (72.06) | 0.785 |
 Scr, mg/dL | 1.27 (1.11) | 1.22 (1.21) | 1.24 (1.02) | 1.25 (1.00) | 1.36 (1.19) | 0.270 |
 BUN, mg/dL | 24.30 (15.87) | 22.54 (12.96) | 23.46 (14.17) | 24.67 (16.45) | 26.44 (18.92) | 0.004 |
 TyG index | 9.14 (0.71) | 8.27 (0.37) | 8.88 (0.13) | 9.33 (0.14) | 10.06 (0.43) |  < 0.001 |
Events | ||||||
 LOS ICU, days | 3.89 (5.80) | 3.40 (6.03) | 3.56 (5.28) | 3.92 (4.62) | 4.65 (6.96) | 0.011 |
 LOS Hospital, days | 7.11 (7.70) | 6.42 (7.10) | 6.63 (7.08) | 7.11 (6.22) | 8.27 (9.81) | 0.003 |
 ICU mortality, n (%) | 123 (7.60) | 16 (4.11) | 28 (6.80) | 40 (9.76) | 39 (9.58) | 0.007 |
 Hospital mortality, n (%) | 156 (9.64) | 20 (5.14) | 35 (8.50) | 50 (12.20) | 51 (12.53) | 0.001 |