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Table 1 Baseline characteristics of critical patients with CHD grouped according to TyG index quartilesa

From: Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database

Categories

Overall

Q1

Q2

Q3

Q4

P-value

(N = 1618)

(N = 389)

(N = 412)

(N = 410)

(N = 407)

Age, years

68.05 (14.05)

70.38 (14.50)

69.46 (14.08)

67.80 (13.72)

64.66 (13.28)

 < 0.001

Male, n (%)

1054 (65.14)

262 (67.35)

264 (64.08)

266 (64.88)

262 (64.37)

0.762

BMI, kg/m2

29.60 (14.85)

29.03 (23.79)

28.99 (11.18)

28.86 (6.38)

31.40 (13.44)

0.180

SOFA score

3.00 (2.58)

2.62 (2.22)

2.71 (2.22)

3.21 (2.65)

3.43 (3.04)

 < 0.001

SIRS score

2.43 (1.05)

2.27 (1.02)

2.35 (1.05)

2.53 (1.04)

2.55 (1.07)

 < 0.001

APSIII

37.29 (17.14)

36.02 (15.26)

35.68 (15.60)

37.70 (17.51)

39.72 (19.55)

0.003

SAPSII

32.45 (12.62)

31.50 (11.55)

31.98 (11.50)

33.15 (13.03)

33.12 (14.15)

0.159

Comorbidities, n (%)

 Heart failure

651 (40.23)

143 (36.76)

158 (38.35)

165 (40.24)

185 (45.45)

0.067

 Hypertension

866 (53.52)

195 (50.13)

228 (55.34)

220 (53.66)

223 (54.79)

0.455

 Atrial fibrillation

401 (24.78)

114 (29.31)

100 (24.27)

101 (24.63)

86 (21.13)

0.064

 Dyslipidemia

420 (25.96)

94 (24.16)

106 (25.73)

97 (23.66)

123 (30.22)

0.131

Diabetes

484 (29.91)

47 (12.08)

77 (18.69)

140 (34.15)

220 (54.05)

 < 0.001

 Respiratory failure

183 (11.31)

27 (6.94)

33 (8.01)

57 (13.90)

66 (16.22)

 < 0.001

 AKIb

830 (51.30)

181 (46.53)

182 (44.17)

228 (55.61)

239 (58.72)

 < 0.001

 CKD

179 (11.06)

43 (11.05)

38 (9.22)

45 (10.98)

53 (13.02)

0.390

 AMI

1,126 (69.65)

264 (67.87)

289 (70.15)

282 (68.78)

291 (71.50)

0.698

 PCI

1,127 (69.65)

261 (67.10)

286 (69.42)

292 (71.22)

288 (70.76)

0.588

 CABG

186 (11.50)

41 (10.54)

35 (8.50)

64 (15.61)

46 (11.30)

0.013

Laboratory tests

 WBC, K/uL

11.76 (5.04)

10.91 (4.61)

11.33 (5.03)

11.88 (4.64)

12.87 (5.59)

 < 0.001

 Lymphocyte, %

15.24 (9.92)

15.69 (11.10)

15.37 (10.40)

14.72 (8.72)

15.25 (9.48)

0.699

 Neutrophil, %

77.80 (12.16)

77.67 (13.16)

77.04 (12.71)

78.36 (10.68)

78.04 (12.16)

0.612

 RBC, m/uL

4.17 (0.68)

4.10 (0.68)

4.18 (0.62)

4.18 (0.68)

4.23 (0.74)

0.040

 Platelet, K/uL

250.27 (96.86)

245.36 (104.94)

249.52 (88.84)

252.96 (98.43)

253.00 (95.15)

0.645

 Hemoglobin, g/dL

12.67 (2.07)

12.46 (2.01)

12.73 (1.95)

12.69 (2.13)

12.77 (2.15)

0.150

 Serum potassium, mEq/L

4.22 (0.77)

4.15 (0.68)

4.22 (0.75)

4.18 (0.76)

4.34 (0.87)

0.004

 Serum sodium, mEq/L

138.23 (4.00)

138.09 (4.52)

138.67 (3.53)

138.11 (3.81)

138.03 (4.07)

0.078

 TC, mg/dL

161.20 (46.30)

148.67 (42.10)

161.24 (48.04)

165.06 (45.82)

169.44 (46.53)

 < 0.001

 TG, mg/dL

132.82 (89.64)

64.82 (22.25)

101.80 (28.19)

134.34 (45.68)

227.71 (119.13)

 < 0.001

 LDL, mg/dL

90.99 (39.95)

85.43 (35.95)

94.35 (42.71)

95.15 (39.97)

88.63 (40.04)

0.001

 HDL, mg/dL

45.05 (14.21)

50.65 (15.15)

46.46 (13.66)

43.60 (13.38)

39.54 (12.27)

 < 0.001

 HbA1c, %

6.45 (1.42)

5.95 (0.98)

6.04 (0.79)

6.25 (1.19)

7.47 (1.85)

 < 0.001

 Glucose, mg/dL

165.39 (86.07)

134.58 (51.49)

146.48 (52.93)

166.13 (83.95)

213.46 (116.12)

 < 0.001

 Albumin, g/dL

3.49 (0.58)

3.48 (0.54)

3.48 (0.60)

3.50 (0.54)

3.49 (0.63)

0.967

 Ucr, mg/dL

95.46 (65.61)

98.04 (66.63)

99.33 (60.41)

89.65 (62.52)

95.71 (72.06)

0.785

 Scr, mg/dL

1.27 (1.11)

1.22 (1.21)

1.24 (1.02)

1.25 (1.00)

1.36 (1.19)

0.270

 BUN, mg/dL

24.30 (15.87)

22.54 (12.96)

23.46 (14.17)

24.67 (16.45)

26.44 (18.92)

0.004

 TyG index

9.14 (0.71)

8.27 (0.37)

8.88 (0.13)

9.33 (0.14)

10.06 (0.43)

 < 0.001

Events

 LOS ICU, days

3.89 (5.80)

3.40 (6.03)

3.56 (5.28)

3.92 (4.62)

4.65 (6.96)

0.011

 LOS Hospital, days

7.11 (7.70)

6.42 (7.10)

6.63 (7.08)

7.11 (6.22)

8.27 (9.81)

0.003

 ICU mortality, n (%)

123 (7.60)

16 (4.11)

28 (6.80)

40 (9.76)

39 (9.58)

0.007

 Hospital mortality, n (%)

156 (9.64)

20 (5.14)

35 (8.50)

50 (12.20)

51 (12.53)

0.001

  1. CHD coronary heart disease, TyG index triglyceride glucose index, BMI body mass index, SOFA sequential organ failure assessment, SIRS systemic inflammatory response syndrome, APSIII acute physiology score III, SAPSII simplifed acute physiological score II, AKI acute kidney injury, CKD chronic kidney disease, AMI acute myocardial infarction, PCI percutaneous coronary intervention CABG coronary artery bypass grafting, WBC white blood cell, RBC red blood cell, TC total cholesterol, TG triglyceride, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c hemoglobin A1c, Ucr urine creatinine, Scr serum creatinine, BUN blood urea nitrogen, LOS length of stay, ICU intensive care unit
  2. aTyG index: Q1 (6.23–8.65), Q2 (8.65–9.10), Q3 (9.10–9.58), Q4 (9.58–11.78)
  3. bAKI was defined according to KDIGO guidelines as an increase in serum creatinine (Scr) by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) from baseline within 48 h