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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease

Fig. 3

Interaction and simple slopes analysis of sex and selenium with prevalence of myocardial infarction. Sex and selenium levels were found to have significant interaction with myocardial infarction (MI) in both PREVEND (3A: pinteraction = 0.021) and BIOSTAT-CHF (3C: pinteraction = 0.084). Johnson-Neyman plots illustrated under which concentrations of selenium the interaction between sex and selenium with prevalent MI was significant (p < 0.05). Again, the effect of female sex was compared with the effect of male sex on the prevalence of MI, for each selenium concentration (i.e. ‘slope of sex’ indicates the direction and magnitude of the relative difference between both sexes). In both PREVEND and BIOSTAT-CHF, females with higher selenium concentrations associated to a lower prevalence of MI as compared to males with higher selenium. The effect range of selenium for which the association between sex and prevalent MI was significant (levels higher than ~ 50 μg/L), showed overlap between both cohorts (3B/3D)

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