Normal range (nmol/ml) | Non-SGLT2i n = 52 | SGLT2i n = 29 | p | |
---|---|---|---|---|
Essential amino acid | ||||
Valine | 158.4–287.7 | 248.1 ± 46.9 | 261.4 ± 58.6 | 0.268 |
Leucine | 80.9–154.3 | 137.1 ± 28.6 | 150.8 ± 42.7 | 0.088 |
Isoleucine | 41.3–84.9 | 81.6 ± 17.4 | 86.3± 28.6 | 0.356 |
Lysine | 118.7–257.0 | 229.8 ± 53.6 | 231.6 ± 53.5 | 0.883 |
Methionine | 19.2–32.7 | 26.8 ± 7.4 | 28.9 ± 9.4 | 0.265 |
Phenylalanine | 45.7–76.5 | 69.6 ± 10.8 | 71.8 ± 12.6 | 0.400 |
Threonine | 89.2–205.0 | 136.4 ± 35.5 | 139.9 ± 46.2 | 0.701 |
Tryptophan | 41.4–65.5 | 45.8 ± 8.95 | 46.9 ± 9.3 | 0.601 |
Histidine | 67.9–97.1 | 73.7 ± 12.4 | 79.0 ± 13.7 | 0.079 |
Tyrosine | 50.2–82.6 | 69.5 ± 14.6 | 69.3 ± 15.1 | 0.961 |
Non-essential amino acid | ||||
Glycine | 153.2–362.1 | 237.0 ± 52.9 | 241.7 ± 55.6 | 0.708 |
Alanine | 239.9 –510.2 | 367.5 ± 105.6 | 381.7 ± 91.8 | 0.546 |
Arginine | 46.0–121.7 | 68.1 ± 21.9 | 65.1 ± 20.8 | 0.558 |
Cystine | 36.5–56.0 | 67.0 ± 18.0 | 70.0 ± 20.3 | 0.494 |
Asparagine | 40.8–76.5 | 62.2 ± 12.0 | 65.0 ± 12.1 | 0.332 |
Aspartic acid | < 3.2 | 4.13 ± 1.23, n = 50 | 4.16 ± 1.04, n = 28 | 0.922 |
Glutamine | 488.2–733.1 | 566.8 ± 71.1 | 551.4 ± 103.5 | 0.431 |
Glutamic acid | 10.8–44.4 | 68.7 ± 24.1 | 77.1 ± 26.6 | 0.151 |
Serine | 91.5–161.8 | 134.4 ± 27.9 | 132.8 ± 36.3 | 0.815 |
Proline | 89.6 –258.8 | 198.0 ± 65.5 | 202.1 ± 48.0 | 0.766 |
Other amino acid metabolites | ||||
Taurine | 35.2–70.0 | 65.9 ± 27.7 | 68.8 ± 18.3 | 0.620 |
Hydroxyproline | 5.4 –18.2 | 12.3 ± 5.5 | 12.9 ± 5.0 | 0.605 |
Citrulline | 20.4–44.8 | 41.8 ± 19.4 | 43.5 ± 18.8 | 0.694 |
β-aminoisobutyric acid (BAIBA) | < 3.7 | 4.56 ± 2.93, n = 35 | 6.76 ± 4.72, n = 27 | 0.028 |
α-Amino-n-butyric acid | 11.0 –25.7 | 25.1 ± 8.7 | 27.7 ± 10.6 | 0.250 |
β-Alanine | < 7.7 | 7.81 ± 2.62 | 8.23 ± 2.59, n = 27 | 0.494 |
Monoethanolamine | 6.0–10.7 | 8.50 ± 1.61, n = 48 | 9.26 ± 2.65, n = 26 | 0.131 |
Ornithine | 43.2–95.7 | 111.1 ± 30.0 | 121.9 ± 45.7 | 0.207 |
1-Methylhistidine | < 12.8 | 13.6 ± 10.1 | 18.5 ± 15.8 | 0.088 |
3-Methylhistidine | 2.9 –6.8 | 9.15 ± 7.24 | 11.82 ± 9.28 | 0.155 |