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Table 2 Associations of HDL-P measurements with incident CVD and all-cause mortality

From: High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

Variable

Incident CVD

All-cause mortality

Unadjusted HR (95% CI)

P value

Adjusted HR (95% CI)

P value

Unadjusted HR (95% CI)

P value

Adjusted HR (95% CI)

P value

Total HDL-P, per SD

0.64 (0.53, 0.76)

< 0.0001

0.71 (0.52, 0.97)

0.03

0.49 (0.40, 0.60)

< 0.0001

0.61 (0.43, 0.86)

0.01

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

0.49 (0.32, 0.74)

0.001

0.59 (0.36, 0.96)

0.03

0.58 (0.37, 0.91)

0.02

1.01 (0.58, 1.74)

0.99

Third tertile

0.39 (0.25, 0.60)

< 0.0001

0.47 (0.23, 0.95)

0.04

0.17 (0.08, 0.35)

< 0.0001

0.46 (0.18, 1.22)

0.12

Very large HDL-P, per SD

1.17 (0.96, 1.42)

0.19

1.44 (1.11, 1.87)

0.01

1.54 (1.19, 1.99)

0.001

1.75 (1.19, 2.58)

0.01

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

2.47 (1.50, 4.07)

0.0004

3.06 (1.79, 5.24)

< 0.0001

1.69 (0.85, 3.38)

0.14

1.49 (0.72, 3.11)

0.28

Third tertile

2.36 (1.43, 3.88)

0.001

3.23 (1.78, 5.85)

0.0001

4.48 (2.45, 8.20)

< 0.0001

4.37 (2.16, 8.84)

< 0.0001

Large HDL-P, per SD

0.91 (0.77, 1.07)

0.28

1.49 (1.13, 1.96)

0.01

1.15 (0.91, 1.45)

0.24

1.85 (1.23, 2.76)

0.01

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

1.08 (0.72, 1.63)

0.70

1.85 (1.13, 3.03)

0.02

1.15 (0.65, 2.04)

0.63

1.89 (0.97, 3.68)

0.06

Third tertile

0.74 (0.47, 1.16)

0.19

2.40 (1.14, 5.03)

0.02

2.00 (1.20, 3.35)

0.01

7.65 (3.52, 16.65)

< 0.0001

Medium HDL-P, per SD

0.70 (0.61, 0.81)

< 0.0001

0.95 (0.72, 1.23)

0.68

0.67 (0.58, 0.78)

< 0.0001

0.89 (0.66, 1.19)

0.42

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

0.56 (0.37, 0.85)

0.01

0.83 (0.50, 1.37)

0.45

0.91 (0.58, 1.42)

0.67

1.64 (0.95, 2.84)

0.08

Third tertile

0.44 (0.29, 0.69)

0.0003

1.11 (0.53, 2.33)

0.79

0.37 (0.21, 0.68)

0.001

1.66 (0.68, 4.04)

0.27

Small HDL-P, per SD

0.70 (0.60, 0.82)

< 0.0001

0.65 (0.52, 0.81)

0.001

0.51 (0.45, 0.57)

< 0.0001

0.47 (0.38, 0.59)

< 0.0001

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

0.67 (0.45, 1.00)

0.05

0.64 (0.40, 1.01)

0.05

0.30 (0.18, 0.50)

< 0.0001

0.45 (0.26, 0.79)

0.01

Third tertile

0.41 (0.26, 0.66)

0.0002

0.39 (0.22, 0.72)

0.002

0.09 (0.04, 0.21)

< 0.0001

0.18 (0.07, 0.46)

0.0003

HDL-P size, per SD

0.91 (0.76, 1.09)

0.33

1.68 (1.28, 2.22)

0.001

1.43 (1.20, 1.70)

< 0.0001

2.93 (2.22, 3.87)

< 0.0001

First tertile

Reference

 

Reference

 

Reference

 

Reference

 

Second tertile

1.27 (0.83, 1.93)

0.27

2.12 (1.29, 3.48)

0.003

1.00 (0.54, 1.85)

0.99

1.51 (0.76, 3.01)

0.24

Third tertile

0.90 (0.58, 1.41)

0.65

2.63 (1.35, 5.12)

0.005

2.46 (1.46, 4.14)

0.001

5.87 (2.84, 12.15)

< 0.0001

  1. All HDL-P measurements were loge-transformed before z-scaling. P values for SD change were false discovery rate corrected
  2. CI confidence interval; CVD cardiovascular disease; HDL-P high-density lipoprotein particles; HR hazard ratio; SD standard deviation
  3. Model adjusted for age, sex, smoking, diabetes duration, systolic blood pressure, body mass index, glycated hemoglobin, estimated glomerular filtration rate, ln (urinary albumin-creatinine ratio), ln (triglycerides), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, glycoprotein acetyls, oral antihyperglycemic drugs, insulin use, renin-angiotensin system blockers, antihypertensive drugs, lipid-lowering drugs, and prevalent CVD (for all-cause mortality)
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Cardiovascular Diabetology

ISSN: 1475-2840