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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level

Fig. 3

Mediating effect of islet beta-cell function. a effect of SBP on 2 h PBG. b effect of 2 h PBG on SBP. All analyses were performed in participants with HbA1c ≥ 10% and in the SBP < 150 mmHg. Mediating effect = Indirect effect 1 × Indirect effect 2. a N = 240 and adjusted age, sex, duration of diabetes, BMI, TG, LDL-C, Matsuda index, insulin treatment, oral hypoglycemic agent treatment, ACE inhibitor/ARB treatment, and other antihypertensive agent treatment. b N = 237 and adjusted age, sex, duration of diabetes, current smoking, current alcohol consumption, BMI, TG, TC, HDL-C, LDL-C, oral antihypertensive agent treatment, and self-reported hypertension. ISSI2, insulin secretion-sensitivity index-2; SBP, systolic blood pressure; PBG, postprandial blood glucose; HbA1c, glycosylated hemoglobin; BMI, body mass index; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker

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Cardiovascular Diabetology

ISSN: 1475-2840