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Table 2 Distributions of clinical, biological and imaging parameters according to the outcome

From: Cardiac adipose tissue volume assessed by computed tomography is a specific and independent predictor of early mortality and critical illness in COVID-19 in type 2-diabetic patients

 

CMU N = 112

ICU OR death N = 90

P-value

Anthropometry

Age, years (IQR)

71 (56–81)

71 (63–80)

0.31

Male, n (%)

63 (56)

64 (71)

0.04

BMI (kg/m2)

25 (22–29)

26 (23–29)

0.63

Cardiometabolic risk profile

Active smoking, n (%)

7 (6)

7 (8)

0.78

Hypertension, n (%)

67 (60)

59 (66)

0.47

Dyslipidemia, n (%)

38 (34)

49 (54)

0.003

CVDs, n (%)

25 (22)

24 (27)

0.51

Adipose tissue imaging biomarkers

CATi (mL/m2)

102 (66–145)

116 (70–157)

0.12

VATi (mL/m2)

506 (291–801)

605 (357–931)

0.26

SATi (mL/m2)

423 (299–640)

452 (255–621)

0.79

CATi/VATi

0.17 (0.12–0.25)

0.18 (0.13–0.24)

0.76

Lung CT severity score

Minimal (10%)

19 (17)

13 (14)

0.06

Moderate (10–25%)

45 (40)

22 (24)

Extensive (25–50%)

35 (31)

39 (43)

Severe (> 50%)

13 (12)

16 (18)

0.23

Minimal (10%) vs > 10%

19 (17)

13 (14)

0.70

Severe (> 50%) vs ≤ 50%

13 (12)

16 (18)

0.23

CAC-DRS Classification

0

29 (26)

17 (19)

0.14

1

49 (44)

32 (36)

2

17 (15)

24 (27)

3

17 (15)

17 (19)

 > 0

29 (26)

17 (19)

0.31

3 vs < 3

17 (15)

17 (19)

0.57

Biological markers

Leukocytes (× 109/L)

6 (4.4–7.3)

6.8 (5.6–8.9)

0.005

Lymphocytes (× 109/L)

1 (0.7–1.3)

0.8 (0.7–1.2)

0.08

Platelets (× 109/L)

215 (160–261)

206 (146–273)

0.38

eGFR (mL/min/1.73 m2)

86 (61–116)

80 (59–100)

0.46

CRP (mg/L)

60 (29–105)

93 (31–143)

0.03

Troponin-T (ng/L)

15 (8–30)

23 (12–46)

0.0007

  1. Data are represented as median (interquartile range) and frequency (percent) as appropriate. Median and frequency differences were tested using Mann–Whitney and chi2 tests. respectively
  2. BMI body mass index, CRP C-reactive protein, CMU conventional medicale care unit, ICU intensive care unit, CATi cardiac adipose tissue index, VATi visceral adipose tissue index, SATi subcutaneous adipose tissue index, CAC-DRS coronary artery calcium data and reporting system. Note: P values in bold indicate statistical significance P<0.05