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Table 3 Fully adjusted risks (hazard ratios) of death within 28 days and cardiorenal complications within 1 year after admission, in relation to baseline conditions

From: Patients with type 1 and type 2 diabetes hospitalized with COVID-19 in comparison with influenza: mortality and cardiorenal complications assessed by nationwide Swedish registry data

 

COVID-19 (11,005 hospitalized patients during 2020–2021)

Death

HF

CKD

CRD

MI

Stroke

Number of events

2025

229

234

442

63

97

T1D vs. T2D

1.44 (1.15–1.81)

1.56 (0.78–3.10)

0.79 (0.38–1.63)

1.11 (0.66–1.85)

1.90 (0.58–6.28)

1.65 (0.59–4.60)

Age (per 10-year increase)

1.97 (1.89–2.06)

1.70 (1.47–1.97)

1.21 (1.07–1.36)

1.38 (1.26–1.52)

1.39 (1.09–1.78)

1.33 (1.10–1.61)

Female sex

0.80 (0.74–0.87)

0.76 (0.57–1.00)

0.91 (0.69–1.20)

0.81 (0.66–0.99)

1.12 (0.67–1.88)

0.92 (0.60–1.41)

HF

1.27 (1.15–1.40)

8.73 (5.52–7.15)

1.35 (0.97–1.88)

3.49 (2.76–4.41)

1.81 (0.98–3.37)

1.06 (0.61–1.85)

CKD

1.56 (1.42–1.72)

1.58 (1.18–2.12)

6.03 (4.50–8.06)

3.05 (2.47–3.77)

1.18 (0.59–2.38)

1.41 (0.79–2.52)

Ischemic heart disease

1.04 (0.96–1.13)

1.13 (0.85–1.50)

0.84 (0.63–1.14)

0.95 (0.77–1.17)

1.92 (1.11–3.33)

1.16 (0.74–1.83)

Stroke

1.16 (1.07–1.27)

0.85 (0.63–1.15)

1.02 (0.74–1.41)

0.93 (0.74–1.17)

1.43 (0.81–2.53)

2.62 (1.70–4.05)

Peripheral artery disease

1.38 (1.22–1.55)

0.98 (0.67–1.45)

1.13 (0.73–1.74)

0.95 (0.70–1.29)

0.83 (0.32–2.14)

0.93 (0.42–2.05)

Pneumonia

1.36 (1.25–1.48)

1.10 (0.83–1.46)

1.46 (1.10–1.95)

1.29 (1.05–1.59)

0.84 (0.45–1.57)

0.99 (0.60–1.63)

COPD

1.08 (0.97–1.21)

1.35 (0.99–1.84)

0.87 (0.58–1.31)

1.15 (0.90–1.48)

0.66 (0.28–1.59)

0.68 (0.32–1.43)

Obesity

1.06 (0.95–1.18)

1.44 (1.06–1.96)

1.13 (0.82–1.56)

1.27 (1.02–1.60)

0.78 (0.37–1.62)

0.48 (0.23–1.00)

Rheumatologic disease

0.97 (0.86–1.09)

1.17 (0.84–1.64)

1.33 (0.95–1.86)

1.28 (1.00–1.63)

1.27 (0.61–2.63)

0.95 (0.48–1.86)

 

Influenza (5111 hospitalized patients during 2015–2019)

Death

HF

CKD

CRD

MI

Stroke

Number of events

247

353

201

525

85

98

T1D vs. T2D

1.62 (1.12–2.33)

0.90 (0.50–1.62)

0.95 (0.56–1.61)

1.02 (0.69–1.51)

1.33 (0.50–3.52)

1.45 (0.55–3.81)

Age (per 10-year increase)

1.79 (1.65–1.95)

1.29 (1.15–1.46)

0.86 (0.75–0.97)

1.08 (0.99–1.18)

1.21 (0.95–1.52)

1.32 (1.06–1.64)

Female sex

0.93 (0.81–1.08)

1.06 (0.86–1.31)

1.24 (0.93–1.65)

1.08 (0.90–1.28)

0.82 (0.52–1.29)

0.91 (0.60–1.37)

HF

1.60 (1.37–1.87)

4.68 (3.62–6.05)

1.20 (0.87–1.66)

2.99 (2.44–3.66)

1.21 (0.75–1.94)

1.11 (0.71–1.76)

CKD

1.37 (1.14–1.63)

1.35 (1.06–1.74)

7.76 (5.70–10.58)

2.53 (2.08–3.06)

1.25 (0.72–2.18)

1.32 (0.78–2.23)

Ischemic heart disease

0.86 (0.74–1.00)

1.45 (1.16–1.82)

1.17 (0.86–1.58)

1.29 (1.07–1.55)

3.25 (1.98–5.33)

1.27 (0.83–1.93)

Stroke

1.25 (1.07–1.45)

0.96 (0.76–1.21)

1.12 (0.82–1.53)

1.03 (0.85–1.25)

1.15 (0.72–1.83)

1.94 (1.29–2.92)

Peripheral artery disease

1.30 (1.06–1.59)

1.32 (0.99–1.77)

1.62 (1.13–2.30)

1.39 (1.11–1.76)

1.58 (0.90–2.77)

0.88 (0.46–1.67)

Pneumonia

1.32 (1.15–1.53)

1.27 (1.03–1.58)

0.99 (0.74–1.32)

1.19 (1.00–1.42)

0.82 (0.51–1.30)

1.06 (0.70–1.61)

COPD

1.19 (0.99–1.43)

1.27 (0.99–1.63)

1.23 (0.86–1.75)

1.24 (1.01–1.53)

0.88 (0.48–1.62)

1.29 (0.77–2.17)

Obesity

1.18 (0.95–1.46)

1.29 (0.98–1.70)

1.00 (0.70–1.43)

1.13 (0.90–1.42)

1.37 (0.76–2.47)

0.89 (0.47–1.68)

Rheumatologic disease

1.34 (1.12–1.62)

1.13 (0.86–1.49)

1.47 (1.05–2.06)

1.26 (1.02–1.57)

0.89 (0.47–1.72)

1.58 (0.93–2.66)

  1. Diabetes patients with type 1 (T1D) or type 2 diabetes (T2D) hospitalized for Covid-19 or influenza. Risks were estimated with age, sex, HF, CKD, ischemic heart disease, stroke, peripheral artery disease, previous pneumonia, COPD, obesity and rheumatologic disease as covariates and presented as adjusted hazard ratio values including 95% confidence interval