Disease patterns of coronary heart disease and type 2 diabetes harbored distinct and shared genetic architecture

Table 1 Single-nucleotide polymorphism (SNP) sets reported significant association with coronary heart disease (CHD) or type 2 diabetes (T2D)

SNP set	SKAT P values		Subjects (N)	SNPs (N)	Disease risk (%)		SNP composition (%)		OR > 1 (%)
SNP set	CHD	T2D	Subjects (N)	SNPs (N)	CHD	T2D	CHD	T2D	OR > 1 (%)
G21	1.52E−03	8.76E−05	159	81	48	48	60	40	74
G22	2.79E−07	1.18E−01	70	34	26	29	50	50	0
G41	3.44E−04	5.19E−01	56	39	75	61	82	18	100
G55	2.79E−07	1.18E−01	53	24	6	58	100	0	0
G63	3.42E−04	7.08E−01	43	14	63	44	100	0	100
G74	1.33E−07	7.23E−01	37	25	16	51	100	0	0
G82	2.69E−05	7.12E−01	128	10	52	45	100	0	100
G84	2.12E−05	1.77E−01	42	14	26	62	71	29	29
G85	1.00E+00	3.84E−05	50	14	26	18	0	100	0
G92	3.09E−01	9.19E−06	42	10	31	43	70	30	30
G107	3.04E−01	1.49E−05	45	8	58	62	0	100	100
G125	5.97E−01	3.16E−05	73	6	42	62	0	100	100
G162	2.12E−05	1.77E−01	34	10	29	35	100	0	0
G164	2.79E−07	1.18E−01	23	17	9	52	100	0	0
G167	2.69E−01	2.12E−05	50	17	42	20	0	100	0
G168	2.79E−07	7.18E−01	24	15	17	29	100	0	0
G169	2.42E−05	1.28E−01	66	4	41	55	50	50	50
G1610	1.39E−01	7.36E−06	39	4	33	5	0	100	0
G1611	2.91E−05	6.06E−01	88	9	42	42	100	0	100
G1613	1.00E+00	7.54E−05	18	5	39	67	0	100	100
G1614	2.12E−05	1.18E−01	57	4	65	44	100	0	100
G1615	1.28E−01	3.17E−05	19	7	63	53	0	100	100
G1616	2.60E−05	5.60E−01	72	7	21	33	100	0	0

ISSN: 1475-2840