Fig. 2

Different disease patterns with distinct genetic architecture and pathway enrichment. A Heatmap of associations of SNP sets with disease patterns of CHD and T2D. Hypergeometric analyses were performed based on common subjects between two sets. *P < 2.17 \(\times {10}^{-3}\). The red bar indicates SNP sets composed of risk alleles, while the blue bar indicates SNP sets composed of protective alleles. Green bar corresponding to SNP sets containing variants for two effect directions. SNP sets for CHD variants are indicated in deep brown whereas SNP sets for T2D variants are indicated in light brown. B Venn plot showed the genes overlapping between different groups. C Significantly enriched KEGG pathways in different disease patterns. X-axis represents − \({log}_{2}\)(P-value). The comorbidity group is indicated in red, the CHD without T2D group is in orange and the T2D without CHD group is in green. D The top 5 significantly enriched GO terms within each disease pattern. E Comparison of levels of cardiometabolic traits between disease patterns of CHD and T2D