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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Disease patterns of coronary heart disease and type 2 diabetes harbored distinct and shared genetic architecture

Fig. 1

Examples of Identified Single-Nucleotide Polymorphism (SNP) Sets Represented as Heatmap Submatrices. Six examples of SNP sets are represented as heatmap biclusters (see supplemental figure S3 for all SNP sets). Allele values are indicated as BB (dark blue), AB (intermediate blue), AA (light blue), and missing (gray). Subject status (i.e., cases and controls) is annotated at the top of the heatmap: cases in red and controls in green. SNP composition (associated with CHD or T2D) and SNP effect direction (risk or protective) are indicated as colored bars at the right side. Genotypic SNP sets were labeled by a pair of numbers representing the maximum number of clusters and the order in which they were selected by the method with a prefix G for genotype. A–C Illustrate SNP sets with different combinations of SNP composition and SNP effect direction, which contributed to varied risk for CHD and T2D. The SNPs within each SNP set can map to different genomic positions and exhibit distinct molecular consequences. D–F present pie charts of the percentage of SNPs within each SNP set that belong to different types of consequence (see Additional file 1: Fig. S4 for molecular consequence in each SNP set)

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