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Table 1 Mendelian randomization estimates for sex-specific associations of genetic liability to type 2 diabetes with lipid fractions in people of European ancestry

From: Investigating sex-specific associations of lipid traits with type 2 diabetes, glycemic traits and sex hormones using Mendelian randomization

Sex

Outcome

Method

Including SNPs identified by Steiger filtering

Excluding SNPs identified by Steiger filtering

SNPs

Beta

95% CI

P value

P value (intercept)

SNPs

Beta

95% CI

P value

P value (intercept)

Women

ApoB

IVW

33

0.02

− 0.02 to 0.05

0.311

 

32

0.02

− 0.00 to 0.05

0.089

 

Women

ApoB

Weighted median

33

− 0.01

− 0.03 to 0.02

0.588

 

32

− 0.004

− 0.03 to 0.02

0.694

 

Women

ApoB

MR Egger

33

0.03

− 0.06 to 0.11

0.570

0.846

32

0.01

− 0.07 to 0.08

0.863

0.601

Women

ApoB

Conmix

33

− 0.02

− 0.03 to 0.04

0.511

 

32

− 0.02

− 0.03 to 0.04

0.101

 

Men

ApoB

IVW

48

− 0.06

− 0.14 to 0.02

0.120

 

47

− 0.03

− 0.05 to -0.01

 < 0.001

 

Men

ApoB

Weighted median

48

− 0.04

− 0.05 to -0.02

 < 0.001

 

47

− 0.04

− 0.05 to -0.02

 < 0.001

 

Men

ApoB

MR Egger

48

− 0.04

− 0.22 to 0.14

0.641

0.833

47

− 0.04

− 0.07 to 0.00

0.068

0.752

Men

ApoB

Conmix

48

− 0.02

− 0.04 to -0.00

0.028

 

47

− 0.05

− 0.06 to -0.02

0.004

 

Women

TG

IVW

33

0.13

0.08 to 0.17

 < 0.001

 

29

0.09

0.07 to 0.12

 < 0.001

 

Women

TG

Weighted median

33

0.09

0.07 to 0.12

 < 0.001

 

29

0.09

0.06 to 0.11

 < 0.001

 

Women

TG

MR Egger

33

0.05

− 0.06 to 0.16

0.346

0.145

29

0.07

0.02 to 0.13

0.014

0.462

Women

TG

Conmix

33

0.11

0.06 to 0.12

 < 0.001

 

29

0.12

0.10 to 0.14

 < 0.001

 

Men

TG

IVW

48

0.03

− 0.01 to 0.07

0.104

 

46

0.03

0.01 to 0.06

0.014

 

Men

TG

Weighted median

48

0.02

− 0.00 to 0.04

0.052

 

46

0.02

− 0.00 to 0.04

0.068

 

Men

TG

MR Egger

48

0.06

− 0.03 to 0.16

0.200

0.512

46

0.06

− 0.00 to 0.12

0.065

0.385

Men

TG

Conmix

48

0.01

− 0.01 to 0.04

0.392

 

46

0.03

− 0.01 to 0.05

0.107

 

Women

Lp(a)

IVW

33

− 0.01

− 0.03 to 0.00

0.067

 

33

− 0.01

− 0.03 to 0.00

0.067

 

Women

Lp(a)

Weighted median

33

− 0.01

− 0.03 to 0.01

0.342

 

33

− 0.01

− 0.03 to 0.01

0.342

 

Women

Lp(a)

MR Egger

33

0.004

− 0.03 to 0.04

0.831

0.313

33

0.004

− 0.03 to 0.04

0.831

0.313

Women

Lp(a)

Conmix

33

− 0.02

− 0.04 to 0.00

0.098

 

33

− 0.02

− 0.04 to 0.00

0.098

 

Men

Lp(a)

IVW

48

− 0.01

− 0.02 to 0.01

0.319

 

48

− 0.01

− 0.02 to 0.01

0.319

 

Men

Lp(a)

Weighted median

48

− 0.01

− 0.03 to 0.01

0.142

 

48

− 0.01

− 0.03 to 0.01

0.142

 

Men

Lp(a)

MR Egger

48

− 0.03

− 0.06 to 0.00

0.076

0.138

48

− 0.03

− 0.06 to 0.00

0.076

0.138

Men

Lp(a)

Conmix

48

− 0.01

− 0.02 to -0.00

0.097

 

48

− 0.01

− 0.02 to -0.00

0.097

 
  1. The SNPs explaining more of the variance in the outcome than in liability to type 2 diabetes identified by Steiger filtering are rs66787104 for apoB in women, rs429358 for apoB in men, rs13391980, rs1399625, rs1562397 and rs2925979 for TG in women, and rs2943657 and rs429358 for TG in men. Estimates are expressed in standard deviation for lipid fractions, and in log odds for type 2 diabetes
  2. ApoB apolipoprotein B, CI confidence interval, Conmix contamination mixture method, IVW inverse variance weighted, Lp(a) lipoprotein(a), TG triglycerides