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Table 6 Risk assessment levels at 90% sensitivity with corresponding specificity

From: Association of biomarkers and risk scores with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus

Test

Risk assessment tool

Echocardiographic parameter

GLS

 ≥ -16%

E/e’

 > 14

e’

 < 8 cm/s

LAVi

 > 34 ml/m2

LVMi

 > 88 g/m2 (F) or 102 g/m2 (M)

Cut point for 90% sensitivity

ARIC-HF (%)

3

5

3

3

4

WATCH-DM

(points)

8

10

8

8

9

NTpBNP (pg/mL)

13

29

13

20

18

hs-TnT (pg/mL)

6

6

5

6

6

AUC

ARIC-HF

63%

59%

54%

52%

59%

WATCH-DM

63%

74%

60%

59%

65%

NTpBNP

63%

69%

55%

65%

67%

hs-TnT

63%

68%

61%

59%

64%

p-value

0.948

 < 0.001

0.452

 < 0.001

0.599

Specificity at the 90% cut point for sensitivity

ARIC-HF

11%

29%

13%

12%

19%

WATCH-DM

12%

38%

15%

12%

22%

NTpBNP

10%

32%

13%

23%

16%

hs-TnT

20%

19%

18%

22%

20%

p-value

0.075

0.173

0.810

0.104

0.749

  1. GLS global longitudinal strain, hs-TnT high sensitivity troponin-T, LAVi left atrial volume indexed to body surface area, LVMi left ventricular mass indexed to body surface area, NTpBNP N-terminal pro-brain natriuretic peptide