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Table 1 Clinical characteristics according to short-term changes in FPG status in women

From: Changes in Fasting plasma glucose status and risk of mortality events in individuals without diabetes over two decades of Follow-up: a pooled cohort analysis

Variables

All

(n = 8272)

NFG to NFG

(n = 5092)

NFG to IFG

(n = 1233)

NFG to T2DM

(n = 107)

IFG to NFG

(n = 445)

IFG to IFG

(n = 1160)

IFG to T2DM

(n = 235)

Continuous variables, mean ± SD

 Age (years)

49.9 ± 6.9

48.8 ± 7.4

51.5 ± 5.3

50.5 ± 6.8

51.0 ± 6.5

52.2 ± 5.2

51.0 ± 6.1

 SBP (mmHg)

116 ± 17.6

113 ± 16.6

118.2 ± 17.5

123.5 ± 17.3

120.1 ± 18.4

122.4 ± 18.2

125.7 ± 19.5

 DBP (mmHg)

72.1 ± 10.5

70.9 ± 10.3

72.8 ± 10.5

74.7 ± 11.1

74.8 ± 10.4

74.4 ± 10.1

76.6 ± 11.2

 BMI (kg/m2)

27.9 ± 5.7

26.9 ± 5.1

28.4 ± 5.9

32.5 ± 6.2

28.5 ± 5.8

29.7 ± 6.3

32.6 ± 6.6

 TC (mmol/L)

5.4 ± 1.1

5.3 ± 1.0

5.5 ± 1.1

5.4 ± 1.2

5.6 ± 1.1

5.7 ± 1.0

5.6 ± 1.2

 FPG (mmol/L)

5.2 ± 0.6

4.9 ± 0.4

5.2 ± 0.3

5.7 ± 0.7

5.8 ± 0.2

6.0 ± 0.3

6.3 ± 0.4

Categorical variables, number (%)

 Ever smoker

2976 (36)

1677 (32.9)

521 (42.3)

33 (30.8)

161 (36.2)

496 (42.8)

88 (37.4)

 Hypertension (yes)

1995 (24.1)

905 (17.8)

341 (27.7)

43 (40.2)

139 (31.2)

444 (38.3)

123 (52.3)

 Hypercholesterolemia (yes)

4546 (55)

2559 (50.3)

727 (59)

60 (56.1)

273 (61.3)

785 (67.7)

142 (60.4)

Outcomes, the incidence rate per 1000 person-years (95%CI)

 Cancer Mortality*

3.34 (3.05–3.65)

2.43 (2.11–2.80)

4.57 (3.78–5.47)

6.64 (3.18–12.21)

4.15 (2.92–5.72)

4.36 (3.58–5.26)

4.34 (2.65–6.70)

 CV Mortality

1.85 (1.65–2.08)

1.25 (1.03–1.50)

2.41 (1.86–3.08)

2.31 (0.63–5.91)

2.19 (1.34–3.38)

2.61 (2.02–3.32)

5.43 (3.55–7.95)

 All-cause Mortality

7.35 (6.93–7.79)

5.38 (4.91–5.88)

9.53 (8.39–10.78)

11.54 (7.05–17.83)

9.31 (7.44–11.51)

10.05 (8.85–11.36)

12.73 (9.74–16.36)

  1. *Only ARIC and TLGS participants were assessed and followed-up for cancer mortality outcomes
  2. As appropriate, baseline data are shown as mean ± standard deviation (SD) or number (percent). Outcome data are shown as incidence rate per 1000 person-years (95% CI)
  3. NFG normal fasting glucose, IFG impaired fasting glucose based on ADA cut-offs (100 mg/dl), T2DM type 2 diabetes mellitus; SBP: systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, FPG fasting plasma glucose, TC total cholesterol, CV cardiovascular, CI confidence interval