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Table 3 Subgroup analysis according to the presence of aura and risk for Myocardial infarction (MI), Ischemic stroke (IS), cardiovascular death (CVD) and all-cause mortality

From: Associations between migraine and major cardiovascular events in type 2 diabetes mellitus

 

N

Event

RATE

aHR Model

aHR Model 1

aHR Model 2

aHR Model 3

aHR Model 4

  

MI

      

No

2,093,300

52,662

3.65

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

Without Aura

129,682

4,220

4.74

1.297 (1.257,1.338)

1.189 (1.152,1.227)

1.184 (1.147,1.222)

1.175 (1.139,1.213)

1.173 (1.137,1.211)

Aura

6,616

234

5.20

1.433 (1.260,1.629)

1.380 (1.214,1.569)

1.371 (1.205,1.558)

1.36 (1.196,1.546)

1.354 (1.191,1.539)

  

IS

      

No

2,093,300

74,838

5.22

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

Without Aura

129,682

5,842

6.61

1.266 (1.232,1.300)

1.114 (1.085,1.144)

1.116 (1.087,1.146)

1.113 (1.083,1.143)

1.112 (1.083,1.143)

Aura

6,616

269

6.01

1.153 (1.023,1.299)

1.079 (0.957,1.216)

1.081 (0.959,1.218)

1.081 (0.959,1.218)

1.077 (0.956,1.214)

  

CVD

      

No

2,093,300

120,888

8.51

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

Without Aura

129,682

9,495

10.87

1.277 (1.251,1.304)

1.147 (1.123,1.171)

1.146 (1.122,1.170)

1.141 (1.117,1.165)

1.140 (1.116,1.164)

Aura

6,616

479

10.84

1.278 (1.168,1.398)

1.214 (1.109,1.328)

1.211 (1.107,1.325)

1.208 (1.105,1.322)

1.204 (1.101,1.317)

  

Death

      

No

2,093,300

163,504

11.25

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

Without Aura

129,682

11,322

12.57

1.116 (1.095,1.138)

1.013 (0.994,1.032)

1.014 (0.994,1.033)

1.018 (0.999,1.038)

1.009 (0.990,1.029)

Aura

6,616

534

11.72

1.045 (0.960,1.137)

1.037 (0.952,1.129)

1.037 (0.953,1.129)

1.043 (0.958,1.136)

1.029 (0.945,1.120)

  1. Bold fonts indicate statistically significance
  2. HR hazard ratio, aHR adjusted hazard ratio, MI myocardial infarction, IS ischemic stroke, CVD Cardiovascular death
  3. aHR Model: Non-adjusted;
  4. bModel 1: age and sex-adjusted;
  5. cModel 2: age, sex, smoking, alcohol consumption, regular physical activity, and low-income adjusted;
  6. dModel 3: Model 2 + hypertension, dyslipidemia, and body mass index adjusted;
  7. eModel 4: Model 3 + duration of diabetes, use of insulin, and more than 3 agents of oral antihyperglycemic agent adjusted
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Cardiovascular Diabetology

ISSN: 1475-2840