Associations between migraine and major cardiovascular events in type 2 diabetes mellitus

Table 2 Risk for Myocardial infarction (MI), Ischemic stroke (IS), cardiovascular death (CVD), and all-cause mortality according to the presence of migraine

	N	Event	RATE	HR Model^a	aHR Model 1^b	aHR Model 2^c	aHR Model 3^d	aHR Model 4^e
Migraine		MI
No	2,093,300	52,662	3.65	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)
Yes	136,298	4,454	4.76	1.303 (1.264,1.343)	1.198 (1.161,1.235)	1.192 (1.156,1.230)	1.184 (1.148,1.221)	1.182 (1.146,1.219)
		IS
No	2,093,300	74,838	5.22	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)	1(Ref.)
Yes	136,298	6,111	6.58	1.260 (1.228,1.294)	1.112 (1.084,1.142)	1.114 (1.086,1.144)	1.111 (1.083,1.141)	1.111(1.082,1.140)
		CVD
No	2,093,300	120,888	8.51	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)	1(Ref.)
Yes	136,298	9,974	10.87	1.277 (1.251,1.304)	1.15 (1.126,1.173)	1.149 (1.125,1.173)	1.144 (1.120,1.168)	1.143(1.120,1.167)
		Death
No	2,093,300	163,504	11.25	1 (Ref.)	1 (Ref.)	1 (Ref.)	1 (Ref.)	1(Ref.)
Yes	136,298	11,856	12.53	1.113 (1.092,1.134)	1.014 (0.995,1.033)	1.015 (0.996,1.034)	1.019 (1.001,1.039)	1.01(0.991,1.029)

Bold fonts indicate statistically significance
HR hazard ratio, aHR adjusted hazard ratio, MI myocardial infarction, IS ischemic stroke, CVD Cardiovascular death
^aHR Model: Non-adjusted;
^bModel 1: age and sex-adjusted;
^cModel 2: age, sex, smoking, alcohol consumption, regular physical activity, and low-income adjusted;
^dModel 3: Model 2 + hypertension, dyslipidemia, and body mass index adjusted;
^eModel 4: Model 3 + duration of diabetes, use of insulin, and more than 3 agents of oral antihyperglycemic agent adjusted

ISSN: 1475-2840